University Of Maryland, Baltimore

This study is testing a new approach for people with HPV-related throat cancer who have surgery. Researchers want to see if a simple blood test can identify patients who are unlikely to need follow-up radiation. If the blood test after surgery shows no signs of leftover cancer, p…

This study is testing a new glue for attaching braces brackets that doesn't require dentists to first etch the tooth with acid. The goal is to see if this new method can protect tooth enamel from damage while keeping the brackets firmly attached. Twenty people getting braces will…

This early-stage study is testing whether adding two experimental treatments—deep heat therapy and a special type of radiation—to standard chemotherapy and immunotherapy is safe and feasible for people with advanced bile duct cancer that cannot be removed by surgery. The goal is …

This study aims to create and test a new artificial blood substitute for emergency use when donated blood is unavailable. The product is designed to carry oxygen and help with blood clotting to treat people with life-threatening bleeding from injuries. Researchers will test how w…

This study is testing if giving an approved drug called daratumumab as an injection under the skin of the thigh works as well as the standard injection in the abdomen. The goal is to see if the thigh is a safe and effective alternative for patients who find abdomen injections too…

This study is testing whether low doses of ketamine can help reduce cravings and withdrawal symptoms in adults who are starting methadone treatment for opioid addiction. Researchers will compare two different low doses given four times over two weeks to see which works better. Pa…

This study is testing whether a drug called onvansertib can help people with small cell lung cancer that has returned after chemotherapy. Researchers will give the drug to 37 patients who have already tried one or two chemotherapy treatments. They want to see if the drug shrinks …

This study is testing whether a program where trained peers provide support can help people stick to their schedule of long-acting injectable HIV medications (for treatment or prevention) and reduce substance use. It will involve 186 adults, primarily from Black communities, who …

This study is testing whether eating a daily serving of broccoli microgreens (young broccoli plants) for two weeks can help improve health in obese breast cancer survivors. Researchers want to see if this simple dietary addition is easy for people to stick to and if it can positi…

This study is testing a non-surgical, focused ultrasound procedure to help people with task-specific hand dystonia. This condition causes involuntary cramping or movements during skilled tasks like writing, typing, or playing an instrument. Researchers will use MRI guidance to ta…

This early-stage study is testing whether diclofenac, an FDA-approved pain and inflammation medication, can help people with alcohol use disorder. Researchers want to see if the drug changes specific brain chemicals linked to alcohol cravings and negative mood. The study will enr…

This study is testing whether using smart insulin pens with continuous glucose monitors and remote doctor visits works better than standard insulin pens with the same monitors and remote visits. It aims to help veterans with type 2 diabetes who take multiple daily insulin injecti…

This study is testing a year-long training program to help nursing home staff better assess and manage pain in residents with dementia. The program involves monthly team meetings, staff education, mentoring, and tracking pain outcomes. Researchers will compare this intensive appr…

This study is testing if adding precise, high-dose radiation to the standard treatment for prostate cancer that has spread to a few other spots in the body can help men live longer without their cancer getting worse. It will compare two groups of men: one gets standard drugs and …

This study is testing a new home-based rehabilitation system for people who have had a stroke. It combines a robotic device that moves the ankle with gentle electrical stimulation to activate leg muscles. The goal is to see if this combination, used at home, can improve leg movem…

This study is testing if lowering a patient's body temperature (therapeutic hypothermia) can help treat Acute Respiratory Distress Syndrome (ARDS), a severe lung injury with a high death rate. About 340 patients with moderate to severe ARDS will be randomly assigned to receive ei…

This study aims to find the better temporary wound care method for severe open leg fractures that need multiple clean-out surgeries. It will compare two common approaches: placing antibiotic beads in the wound versus using a vacuum-sealed dressing (wound VAC). The goal is to see …

This study aims to find the safest and most effective dose of two chemotherapy drugs when given alongside a targeted form of radiation called proton therapy for locally advanced pancreatic cancer. It will involve 24 participants whose cancer cannot be surgically removed. The goal…

This study is testing how a new drug called Imdusiran works inside the liver of people with chronic hepatitis B. Up to 10 participants already on standard antiviral pills will receive four injections of the drug over several months and undergo two liver biopsies to measure the dr…

This study is testing a two-step treatment for brain tumors (gliomas) that have come back. First, doctors use a laser to heat and destroy tumor tissue. Then, patients receive a short, intense course of radiation therapy. The goal is to see if this combination can control the tumo…

This early-stage study is checking if a vaccine normally used to prevent hepatitis B is safe for people who already have a long-term infection. Researchers will give two vaccine shots to 10 adults whose infection is currently controlled with medication. The main goal is to see wh…

This study compares two bone graft materials used to preserve jawbone after a tooth is pulled. When a tooth is removed, the jawbone can shrink, making it harder to place a dental implant later. Researchers want to see if mixing human-derived bone with animal-derived bone works be…

This study is testing whether a single, highly focused dose of radiation given before breast cancer surgery is safe and effective. It uses a special machine called GammaPod that targets only the tumor area to spare healthy tissue. Researchers want to find the best dose that minim…

This study is testing a specialized radiation machine called GammaPod that delivers a concentrated 'boost' dose to the area where a breast tumor was removed. Researchers want to see if this targeted approach can shorten treatment time by 3-4 sessions while maintaining effectivene…

This study is testing if a prebiotic fiber supplement can help people with schizophrenia or schizoaffective disorder. Researchers think the supplement might reduce harmful inflammation in the body and brain, which could improve thinking skills and other symptoms. For 12 weeks, 60…

This study is testing a new type of MRI scan to see if it can help doctors better diagnose brain tumors called gliomas. Up to 5 adults with suspected or known gliomas will receive the new scan to check its safety and accuracy. Researchers will compare the new scan's results to st…

This study is testing a new type of MRI scan that tracks how cancer cells use sugar. The goal is to see if this method can create clearer pictures of different types of tumors to help doctors better understand them. The study is enrolling 25 people who already have a cancer diagn…

This study tests a personalized training program to help older adults at high risk of falling. Researchers will assess each participant's specific balance weaknesses and create custom exercises done both in a lab and at home over six weeks. The goal is to reduce fall risks throug…

This study is testing whether a 10-week parenting support program can help prevent common health problems in low-income Latino infants. Researchers will enroll 260 mothers and their 9-month-old babies to compare the parenting program against a book-sharing program. They will trac…

This study is testing whether using a virtual reality (VR) headset can help reduce pain for adults with sickle cell disease who come to the emergency room with a severe pain crisis. It will add VR sessions to the usual pain medications to see if it makes patients feel better. Res…

This study is testing whether a virtual reality (VR) program used at home can help people manage common symptoms after cancer treatment, like pain, fatigue, anxiety, and trouble sleeping. It will compare the VR program to a similar audio-only program to see which is more helpful.…

This study is testing if using immersive virtual reality (VR) can help reduce chronic jaw pain. Researchers will compare a real VR experience to a fake one to see if it changes brain activity and helps people tolerate more pain. The goal is to understand if VR could become a safe…

This study is testing whether taking methadone twice a day instead of once a day helps people better manage chronic pain while being treated for opioid addiction. It will involve 150 adults already receiving stable methadone treatment. Researchers will compare pain levels and tre…

This study aims to understand why scar tissue forms and narrows the windpipe, a condition called tracheal stenosis. Researchers will analyze small pieces of scar tissue removed from 10 patients during their standard medical procedures. The goal is to learn about the disease's bio…

This study aims to understand if training on a mock musical instrument can improve the brain's internal wiring in people with schizophrenia. Researchers will use brain scans to measure changes in brain tissue structure and chemistry in 36 participants. The goal is to learn more a…

This study aims to learn how the body's immune system responds to a common oral typhoid vaccine. Healthy adult volunteers will receive the approved vaccine and provide blood, saliva, and stool samples over several years. Researchers will analyze these samples to understand the bo…

This study aims to understand how different levels of low blood sugar affect blood vessel function and heart health risks. Researchers will monitor 32 healthy volunteers while carefully lowering their blood sugar to specific levels. The goal is to gather basic knowledge about how…

This is a small, early-stage research study to see if a type of magnetic brain stimulation is safe and can change brain activity in people with schizophrenia. Researchers will give 34 participants either real or fake stimulation for five days and measure changes in their brain si…

This study is testing a new, non-contact imaging technique called Brillouin microscopy to measure the stiffness of the cornea in people with glaucoma. Researchers want to see if cornea stiffness differs between people with different types of glaucoma and healthy individuals, and …

This study aims to understand why people experience opioid withdrawal symptoms differently. Researchers will observe 60 adults with opioid use disorder during a medically supervised withdrawal process. They will measure symptoms and test a withdrawal medication to gather informat…

This study aims to understand why some people develop serious eye problems after cancer treatments like chemotherapy or bone marrow transplants. Researchers will collect health data and small samples (like eye wash and blood) from 150 adults who have had cancer therapy, as well a…

This study aims to understand if changes in blood flow regulation in the eye can serve as an early warning sign for glaucoma. Researchers will compare 90 participants—some with early glaucoma, some at risk, and some healthy controls—using advanced imaging to measure blood flow in…

This study is testing if patients can safely go home the same day after a knee or hip replacement without needing final clearance from a physical therapist. Instead, patients get training before surgery and nurses help them walk after. Researchers will track if this change leads …

This registry aims to collect safety data on carotid artery stenting procedures to help identify the most skilled doctors for a larger, related clinical trial. It will enroll up to 8,000 patients with narrowed neck arteries who are at risk of stroke. The main goal is to track str…

This early research study aims to understand if two substances—the antidepressant fluoxetine (Prozac) and/or a hormone called DHEA—can help the body better defend itself against dangerously low blood sugar (hypoglycemia) in people with Type 1 diabetes. Researchers will measure th…

This study aims to build a foundation for future research on polycystic kidney disease (PKD). It will enroll 350 adults with PKD to collect detailed health information and biological samples like blood and urine. The goal is to create a resource that helps scientists design bette…

This study aims to understand why some cancer patients develop severe, painful dry eye disease after a bone marrow transplant, a condition called ocular graft-versus-host disease. Researchers will collect small samples from the eye's surface and blood from 150 adult patients over…