University Of Bern

This study tests a new smartphone-based system that automatically delivers insulin for people with type 1 diabetes. Six adults who already use insulin pumps will try the system for a short time under close supervision. The goal is to see if the technology works safely and reliabl…

This study looks at whether placing a permanent crown on a dental implant right away (immediate loading) works as well as waiting 4 weeks (early loading) for lower first molars. About 100 adults who need a tooth removed and replaced will get an implant 12-16 weeks after extractio…

This study compares two surgical methods to improve the volume of gum tissue where a dental bridge will sit. One method uses a small piece of the patient's own connective tissue, the other uses a collagen material. The goal is to see which approach gives better and more lasting r…

This study tests whether adding platelet-rich fibrin (PRF), made from a patient's own blood, to standard surgery improves healing of bone and gum damage around dental implants. Forty adults with peri-implantitis will be randomly assigned to receive either surgery with PRF or surg…

This study tests whether a new collagen matrix can work as well as a traditional gum graft for covering exposed tooth roots. Sixty adults who had braces and now have gum recession will receive either the collagen matrix or a graft taken from the roof of their mouth. The goal is t…

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests a new type of dental bridge called the T-bridge, which uses just one implant to replace three missing back teeth. Researchers want to see how well the implant and bridge hold up over time. The study will include 50 adults who are missing three adjacent teeth and …

This study tests whether adding a weekly medicine called tirzepatide to usual insulin therapy helps adults with type 1 diabetes control their blood sugar better. About 42 people aged 18-65 who already use an automated insulin pump will take part. The goal is to see if the combina…

This study is testing whether a special chewing gum containing galactooligosaccharides (GOS) can help overweight adults lose weight and improve their metabolism. Researchers will measure changes in body mass index (BMI), blood pressure, and gut bacteria over time. The study aims …

This study in Zimbabwe tests whether adding antidepressants (fluoxetine or sertraline) to a proven talk therapy program (Friendship Bench) works better than talk therapy alone for adults with moderate to severe depression. About 296 participants will be randomly assigned to one o…

This study tests two materials used to fill bone defects caused by gum disease: a collagen matrix and a bovine bone mineral. 80 adults with advanced periodontitis will receive one of the two during surgery. Researchers will measure changes in gum attachment and other healing sign…

This study tests whether a modified ketogenic diet (very low in carbs) can help people with alcohol use disorder reduce their drinking. Fifty adults with the condition will follow the diet and receive nutritional counseling. Researchers will measure how well participants stick to…

This study tests a portable device that plays soft sounds during deep sleep to improve memory and slow cognitive decline in older adults. Sixty participants aged 60-85 with mild memory problems will use the device at home for two 4-week periods. The goal is to see if enhancing sl…

This study tests whether applying a special gel (cross-linked hyaluronic acid) during root-end surgery helps the gums heal faster and reduces pain afterward. About 46 adults with a tooth infection that didn't heal after standard root canal treatment will take part. Half will get …

This study tests a digital program called UKADO for people waiting for face-to-face therapy for depression or anxiety. About 312 adults will try different versions of the program—some focused on problems, others on strengths—with or without human support. The goal is to see which…

This study explores whether increasing non-exercise activity—like walking to the store or doing chores—can improve energy levels in people with major depression. Researchers will use smartphone prompts and activity trackers to encourage small movements throughout the day. The goa…

This study follows people who survived childhood cancer for at least five years to learn about the long-term effects of the disease and its treatment. Researchers send questionnaires to survivors to gather information on quality of life, physical and mental health, medication use…

This study gathers international experts to agree on what makes a high-quality contrast-enhanced ultrasound (CEUS) of the liver. Using a Delphi process, they will rate and refine quality indicators. The goal is to create a standardized tool for assessing image quality, improving …

This study looks at 500 adult survivors of childhood cancer to see if a newer type of heart ultrasound, called speckle tracking, can find heart problems earlier than the usual method. Researchers want to know if this technique can detect heart damage sooner, which could help with…

This study tests a program to help doctors and patients safely reduce or stop taking acid-reducing pills (proton pump inhibitors) when they are no longer needed. About 400 adults in Swiss primary care who take these pills daily will be enrolled. The goal is to see if the program …

This study looks at people who have long-lasting health problems after getting the COVID-19 vaccine, a condition called Post-Acute COVID-19 Vaccination Syndrome (PACVS). Researchers will track symptoms over eight months and test blood and blood vessel function to find biological …

This study follows 6,000 children in Switzerland who have breathing issues like wheezing, coughing, or trouble breathing during exercise. Researchers collect information from doctor visits and surveys to better understand these problems and improve care. The goal is to learn more…

This registry collects information from up to 15,000 people with cerebral palsy in Switzerland, tracking their diagnosis, treatments, and outcomes over time. Researchers will use this data to study the condition and improve care. Participants must have a confirmed CP diagnosis an…

This study aims to see if sensors inside a car can tell when a driver is impaired by cannabis. Forty-five healthy adults who regularly use cannabis will drive on a closed track after smoking a controlled dose of THC. Their driving behavior, eye movements, and other data will be c…

This study looks at how a brief therapy program called ASSIP affects thinking and behavior in adults who have attempted suicide. Participants are randomly assigned to receive ASSIP or standard care plus a resource interview. Researchers measure changes in impulse control and othe…

This study looks at how the brain works in people who have attempted suicide compared to those who have only thought about it. Researchers will use simple computer tasks to measure things like impulse control and attention. The goal is to find patterns that might help predict who…

This study is a registry that collects health information from people in Switzerland who have neuromuscular disorders like SMA, DMD, BMD, and others. It aims to track symptoms, treatments, and outcomes over time to help researchers and doctors improve care. No new treatments are …

This study is checking how common liver disease (MASLD) is in people who survived breast or colorectal cancer. Researchers will use painless scans and blood tests instead of a liver biopsy. The goal is to find better ways to catch liver problems early in cancer survivors.

This study looks at whether the chemicals in your breath change throughout the day and if those changes are different for people with diabetes. Researchers will measure breath samples from 60 adults—some without diabetes, some with type 1, and some with type 2. The goal is to lea…

This study follows 1000 people with Primary Ciliary Dyskinesia (PCD) across multiple countries to track ear, nose, and throat symptoms over two years. Participants continue their usual care while researchers collect data through exams and questionnaires. The goal is to better und…

This study tracks people with primary ciliary dyskinesia (PCD) worldwide to understand their symptoms, treatments, and daily life. Participants fill out questionnaires when they join and once a year after that. The goal is to gather real-world data to improve health and quality o…

This study is building a national registry in Switzerland for people of any age with a rare disease or strong suspicion of one. Researchers will collect data on diagnoses, genetics, and disease history to better understand these conditions. The registry aims to support research, …

This study is creating a national registry in Switzerland for people with primary ciliary dyskinesia (PCD), a rare lung condition. Researchers will collect information on symptoms, lung function, and treatments from up to 800 patients. The goal is to better understand the disease…

This study follows 3,000 childhood cancer survivors in Switzerland to learn about long-term health problems caused by cancer treatments. Participants undergo physical exams, lab tests, and questionnaires during regular follow-up visits. The goal is to better understand and manage…

This study uses a safe, non-invasive technique called transcranial direct current stimulation (tDCS) to apply a very weak electrical current to the scalp of healthy adults. Researchers will compare how younger (20-40) and older (60-80) participants perform computer tasks and how …