Memorial Sloan Kettering Cancer Center

This study tests whether giving an extra-high radiation dose directly to the main prostate tumor, along with standard radiation to the rest of the prostate, can cure intermediate-risk prostate cancer or keep it from coming back longer. About 91 men with intermediate-risk prostate…

This study tests whether adding a precise, high-dose radiation treatment (SBRT) can restore the effectiveness of immunotherapy drugs in people with metastatic cancers like melanoma, lung, bladder, kidney, or head/neck cancer. About 69 adults whose cancer has started growing again…

This study tests a drug called amivantamab in people with a specific type of advanced stomach or esophagus cancer that has a change in the EGFR or MET gene. The goal is to see if the drug can shrink tumors and how safe it is. About 25 adults who have already tried at least one ot…

This early-phase study tests whether a second, highly focused dose of radiation can safely treat spine tumors that have grown back after initial radiation. Nine adults with cancer that spread to the lower spine received one of three radiation doses. The main goal is to check for …

This study tests the safety of a drug called neratinib in children and teens with solid tumors, brain tumors, lymphoma, or leukemia that have returned or not responded to standard treatments. The goal is to find the best dose and see what side effects occur. The study involves 14…

This pilot study tests a drug called meclofenamate, previously used for pain, in 30 adults with brain metastases that have come back or worsened. The main goal is to see if a larger study is possible, not to prove the drug works. Researchers will also track side effects and how l…

This study is for people aged 1 to 30 who have just been diagnosed with a rare cancer called desmoplastic small round cell tumor (DSRCT). Researchers are adding three drugs—irinotecan, temozolomide, and bevacizumab—to the usual chemotherapy to see if the combination is safe and t…

This study tests whether two drugs, etrumadenant and zimberelimab, can shrink or control advanced dedifferentiated liposarcoma that has returned, spread, or cannot be removed by surgery. About 16 adults with this rare cancer will receive the combination. The goal is to see how ma…

This study tests a different, experimental dosing schedule of the chemotherapy drug capecitabine combined with the targeted drug neratinib in people with advanced HER2-positive breast cancer. The goal is to find the safest dose that still works. About 34 adults with stage IV brea…

This study tests a treatment called ide-cel (a type of CAR T cell therapy) for people with multiple myeloma that has returned or not responded to treatment. Participants have already had a stem cell transplant. The goal is to see if these specially engineered immune cells can be …

This study tests whether a special camera (RCM/OCT) can help doctors aim radiation more precisely at basal cell carcinoma tumors. About 38 adults with early-stage skin cancer will receive radiation guided by this imaging. Researchers will check if the tumor is gone after treatmen…

This study tests whether combining three drugs—temozolomide, cisplatin, and nivolumab—can shrink tumors in people with advanced colorectal cancer that has not responded to at least two prior treatments. The cancer must be a specific type called MMR-proficient. The trial involves …

This study looks at whether using ultrasound before surgery can help identify early-stage HR+/HER2- breast cancer patients who have only a few affected lymph nodes. If so, they may be able to avoid a more invasive procedure called ALND, which removes many lymph nodes and can caus…

This study tests the drug CPI-613 in people with Burkitt lymphoma/leukemia or high-grade B-cell lymphoma that has come back or not responded to prior treatment. About 24 participants aged 12 and older will receive the drug to see if it can shrink or control their cancer. The goal…

This early-phase trial tests a new treatment called MCARH109 for people with multiple myeloma that has returned or not responded to at least three prior therapies. The treatment uses specially modified immune cells (CAR T-cells) to target a protein called GPRC5D on myeloma cells.…

This study is testing a combination of two drugs, venetoclax and obinutuzumab, in people with chronic lymphocytic leukemia (CLL) who have not yet had treatment. The goal is to see how well this therapy controls the disease and delays its progression. About 100 participants will b…

This study compares two maintenance therapies—daratumumab and lenalidomide—for people with newly diagnosed multiple myeloma who have responded well to initial treatment. About 95 participants will be randomly assigned to one of the two drugs, and researchers will measure their qu…

This study tested the drug pembrolizumab in 19 people with early-stage NK/T-cell lymphoma who had not yet received chemotherapy. The goal was to see if the drug could shrink tumors. Pembrolizumab helps the immune system attack cancer cells. The study is complete and results are b…

This study tests whether giving a second, early infusion of the CAR T-cell therapy tisagenlecleucel can keep the immune system's B cells suppressed for at least 6 months in children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. About 30 part…

This study explores whether a blood test called NavDx can find early signs of HPV-related oropharyngeal cancer by looking for tiny bits of HPV DNA in the bloodstream. Researchers are testing 9 adults aged 45 and older with a history of multiple sexual partners. If successful, thi…

This study compares a newer imaging method using indocyanine green (ICG) with the standard method (lymphoscintigraphy) to find sentinel lymph nodes in people with early-stage vulvar cancer. About 22 participants will receive both imaging techniques during their scheduled surgery.…

This study tests a new type of DCE-MRI that takes clearer, faster images of gynecologic cancers. It aims to reduce blurring from movement and give doctors more detailed information about tumors. The study includes 24 women—healthy volunteers and those with gynecologic cancer—and …

This study tests whether giving patients their own stool (collected before transplant) after a stem cell transplant can prevent a serious gut infection called C. difficile. About 59 adults receiving a stem cell transplant will take part. The approach aims to restore healthy gut b…

This early-stage study tests whether adding N-acetylcysteine (N-AC), a common supplement, to standard CAR T-cell therapy (Yescarta) can reduce side effects in people with lymphoma. Researchers are testing different doses of N-AC in 9 adults to find the safest dose. The goal is to…

This study compares two acupuncture methods—personalized electro-acupuncture and auricular (ear) acupuncture—against usual care for treating chronic pain. About 360 adults with musculoskeletal pain or fibromyalgia will be assigned to one of three groups. The goal is to see which …

This study tests whether acupuncture can reduce frequent nighttime urination (nocturia) in prostate cancer survivors. Researchers will see if acupuncture is practical and helpful for these patients. The study involves 60 participants and also looks at other symptoms like sleep pr…

This study tests whether adding an interactive 3D visualization tool to standard surgical consultations helps women feel more satisfied with the information they receive about breast reconstruction options. About 88 women planning mastectomy will participate. Researchers will mea…

This study looks at whether a simple blood test can find signs that aggressive B-cell Non-Hodgkin lymphoma has returned after chemotherapy, possibly earlier than CT scans. About 501 adults who have finished initial treatment will give blood samples to check for minimal residual d…

This small study looks at how the drug tucatinib enters and acts in the brain in people with HER2+ cancers that have spread there. Researchers will compare genetic differences between cancers that have become resistant to tucatinib and those being treated for the first time. Nine…

This study looks at how common peripheral arterial disease (PAD) is in cancer patients who have risk factors like diabetes or smoking. PAD causes poor blood flow due to narrowed or blocked blood vessels. The goal is to find out how often PAD occurs in these patients and compare r…

This study looks at how to offer BRCA gene testing to more people, especially those of Ashkenazi Jewish descent, and make it a routine part of medical care. Over 5,400 participants will receive education before testing and can choose how to get their results. The goal is to under…

This study aims to improve how MRI scans work by testing new software and hardware techniques. About 667 healthy adults aged 18 and older will participate. The goal is to see if these new methods can produce better images and help doctors make more confident diagnoses. No treatme…

This study tests a new tracer for PET scans to take pictures of brain tumors in 17 adults. The tracer is given in very small amounts to see how it spreads and leaves the body. The goal is to learn more about brain tumors, not to treat them directly.

This study looks at how well a cardiopulmonary exercise test (CPET) works in women with HER2-positive breast cancer who have mild heart issues from their cancer treatment. The goal is to see if this test can help predict how their heart and lungs will handle continued therapy. Ab…

This study aims to understand why some families have a higher chance of developing cancer. Researchers are collecting blood and saliva samples from about 992 people with cancer and their relatives. The samples will be stored and used later to study genetic links to cancers like b…

This study looks at how regular exercise may change the biology of breast tumors in women with early-stage breast cancer. Researchers will compare tumors from women who exercise regularly with those who do not. The goal is to understand exercise's impact on tumor genetics and imm…

This study follows 546 women with non-metastatic breast cancer to see how chemotherapy and hormone therapy affect their hair, skin, and nails. Researchers look for genetic and clinical factors that raise the risk of these side effects. The goal is to better understand and eventua…

This study follows 338 adults with two or more ground glass opacities (GGOs) in their lungs. Instead of immediate treatment, doctors monitor the spots with regular CT scans to see if any turn into lung cancer. The goal is to collect information that helps understand these spots a…

This study follows 810 young women (ages 18-45) with early-stage breast cancer to understand how treatment affects their menstrual cycles and quality of life. Researchers track when periods stop, what symptoms occur, and what factors (like age or smoking) might predict these chan…

This pilot study explores whether a non-invasive brain stimulation technique called tDCS, combined with memory exercises, is practical and tolerable for breast cancer survivors who have memory problems after chemotherapy. The study enrolled 18 survivors aged 40-65 who completed t…

This study looks at tissue from liver tumors that were destroyed by heat or cold (ablation). The goal is to see if a lab test on that tissue can tell whether the treatment fully killed the cancer, which CT scans cannot always show. About 150 people with liver cancer that spread f…

This study collects tissue, blood, and fluid samples from men with prostate conditions (including those without cancer) to help researchers understand prostate cancer better. The goal is to find genetic changes and protein markers that explain why some men get prostate cancer, wh…

This study uses three types of advanced MRI scans (DCE-MRI, DW-MRI, and MRS) to see if they can predict how well head and neck cancer patients will respond to surgery or chemo-radiation. About 272 adults with head and neck cancer will have these scans before and early during trea…

This study looks at the long-term health and quality of life of 473 adults who had retinoblastoma, a rare eye cancer, as children. Researchers want to understand their physical and emotional health, vision, and risk of new cancers. The goal is to improve care and follow-up for fu…

This study looks at whether brain scans and spinal fluid tests can find early signs of brain cancer in people with HER2-positive breast cancer. The goal is to catch and treat brain metastases before they cause symptoms. About 9 participants with stage II, III, or IV HER2+ breast …

This study looks at whether people with Lynch Syndrome, a condition that raises the risk for several cancers, follow recommended screening guidelines after genetic counseling. Researchers will track about 1,530 participants to see who gets the suggested tests and what factors hel…

This study trains doctors, nurses, and other cancer care providers in a special type of talk therapy called Meaning-Centered Psychotherapy. The goal is to help these clinicians better support cancer patients' emotional and spiritual needs. About 350 providers will take part in th…