Can a common supplement make CAR t therapy safer for lymphoma?

NCT ID NCT05081479

First seen Nov 06, 2025 · Last updated May 01, 2026 · Updated 26 times

Summary

This early-stage study tests whether adding N-acetylcysteine (N-AC), a common supplement, to standard CAR T-cell therapy (Yescarta) can reduce side effects in people with lymphoma. Researchers are testing different doses of N-AC in 9 adults to find the safest dose. The goal is to improve how well patients tolerate treatment.

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Contacts and locations

Locations

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison, New York, 10604, United States

Conditions

Explore the condition pages connected to this study.