Johns Hopkins University

This study tests whether nurse-led treatment for drug-resistant tuberculosis (TB) in local clinics works as well as standard doctor-led care in hospitals. About 2,944 people in South Africa will take part. The goal is to see if nurse-led care can make treatment more accessible an…

This study tests whether the drug Isturisa can improve health problems caused by mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Ten adults with MACS will take Isturisa for two years while researchers track changes in blood sugar, ch…

This study compares getting flap surgery within 72 hours of a severe leg injury versus waiting longer. The goal is to see if faster surgery reduces serious problems like infection, the need for more operations, or amputation. About 356 adults with open fractures or dislocations b…

This study tests a program called PICU Up! that helps children on breathing machines start moving earlier. The program combines gentle activity, better sedation, and family involvement. Researchers want to see if it reduces time on the ventilator and improves recovery. About 1,44…

This study tests a 6-month program that combines exercise training, problem-solving skills, and support from community health workers. It includes 210 adults with type 2 diabetes, obesity, and early heart problems who have low income. The goal is to see if this approach improves …

This study tests whether using a special walking analysis and custom shoe inserts can reduce the chance of foot ulcers coming back or leading to amputation in people who have had a diabetic foot ulcer before. About 69 adults with healed foot ulcers will be followed to see if this…

This study tests a new device, a vestibular implant, to help older adults (ages 65-90) who suffer from long-term balance problems and dizziness due to inner ear damage. The implant electrically stimulates the balance nerve to improve stability and vision during movement. Research…

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral approach works just as well but causes fewer side effects. About 1,030 hospitalized adults will take par…

This study tests a program to help 800 adults in Africa better control their high blood pressure. The program works with patients, doctors, and the health system to lower blood pressure and reduce risks of heart disease, stroke, and kidney problems. Participants must have high bl…

This study compares two ways to help teens reduce alcohol use: brief counseling alone versus brief counseling plus a smartphone app that teaches mindfulness. About 1,500 teens aged 12-17 who already drink will be randomly assigned to one of the two groups. Researchers will track …

This early study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder cut back or stop using cannabis. Twelve adults will receive two psilocybin sessions with psychological support over 12 weeks, and their cannabis use wil…

This early-stage study tests a new robot called ProBot, designed to make prostate biopsies more precise and comfortable. The robot uses a special ultrasound probe and can be operated hands-free by the doctor. The study will enroll 60 men at high risk for prostate cancer to see if…

This study is testing a simple, non-invasive method to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string, which collects cells from the esophagus and stomach. Researchers then analyze DNA changes …

This study compares non-opioid pain control to standard opioid pain control after laparoscopic tubal sterilization (getting tubes tied). About 120 women will report their pain and satisfaction after surgery. The goal is to see if avoiding opioids can still manage pain well.

This study is testing a wellness program for adults with cystic fibrosis who feel very tired. The program includes coaching sessions to help improve sleep, energy, and physical activity. Researchers will see if people stick with the program and if it helps them feel better compar…

This study tests whether the drug vortioxetine can improve mood symptoms and thinking skills in people with early-stage behavioral variant frontotemporal dementia (bvFTD). About 50 participants will receive 12 weeks of treatment and undergo brain scans and memory tests before and…

This study tests whether oral cannabidiol (CBD) can help people quit smoking tobacco. Researchers will give CBD to 50 adults who smoke at least 10 cigarettes daily and want to quit. The goal is to see if CBD increases short-term abstinence and understand how it affects smoking be…

This study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain how the brain feels pain. Researchers will enroll 40 adults with chronic pancreatitis whose abdominal pain hasn't improved with standard treatments. Participants wi…

This study looks at whether listening to Mozart or other age-appropriate music can lower the number of seizures or abnormal brain signals in children with epilepsy. Ten children aged 4 to 17 staying in a hospital epilepsy monitoring unit will participate. Researchers will measure…

This study looks at whether a single high dose of psilocybin (the active ingredient in magic mushrooms) can help people with both chronic low back pain and depression. About 40 adults will receive either psilocybin or a control drug, and researchers will track changes in mood, pa…

This study looks at whether cannabidiol (CBD) can reduce stress and nicotine withdrawal symptoms in people who smoke cigarettes. About 90 smokers will take CBD and then be exposed to stress. Researchers will measure mood, stress hormones, and vital signs. The goal is to see if CB…

This study looks at whether adding a structured yoga program to usual care can reduce back pain and improve quality of life for teens with scoliosis. About 500 participants aged 10-20 who have not had surgery will be randomly assigned to either standard care alone or standard car…

This study looks at how women with bladder cancer cope with emotional distress and sexual health issues. About 80 participants will either receive standard care or extra educational support. They will fill out surveys about their mood and sexual function. The goal is to see if ed…

This study tests whether a low-dose, slow-release drug called AGB101 can reduce overactivity in a key memory region of the brain in healthy older adults. Over 60 participants aged 50-80 will receive both the drug and a placebo in random order, each for two weeks. The main goal is…

This study is testing a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. The goal is to see if this approach increases the number of potential donors who come forward and leads to more transplants. …

This study gives healthy adults psilocybin (the active ingredient in magic mushrooms) and uses brain scans and thinking tasks to understand how it changes thoughts and brain activity. Researchers will compare results when participants take psilocybin versus a placebo. The goal is…

This study looks at whether damage to the brain's protective barrier (the blood-brain barrier) right after a stroke can help predict who will have memory or thinking problems in the next three years. Researchers will follow 150 people who had a stroke, using phone-based memory te…

This study uses a special eye scan (OCT angiography) to look at blood vessels in the retina of people with conditions like diabetic retinopathy and retinal vein occlusion. Researchers want to find better ways to detect early disease changes or improvements from standard treatment…

This study creates a database of up to 400 children and young adults (under 26) with eczema who have used or plan to use systemic (whole-body) treatments. Researchers will track how well these treatments work by reviewing medical records and patient surveys. The goal is to make i…

This study looks at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (AFib) before they have a procedure called ablation. The goal is to see if more scarring leads to a higher chance of AFib coming back or needing hospital care…

This study aims to understand how methylphenidate (a common ADHD medication) changes brain activity and chemical levels in adults with ADHD. Thirty right-handed adults will receive both the drug and a placebo in random order, then undergo brain scans and thinking tests. The goal …

This study aims to learn how commercial kratom extract products affect the body and mind of adults who use them regularly. Researchers will measure drug effects, cognitive performance, pupil size, and heart rate, and interview participants about their experiences. The study invol…

This study uses a special MRI technique to measure how the heart produces and uses energy, without needing blood samples or tissue biopsies. Researchers will compare healthy volunteers, people with heart failure, and those with other heart conditions to see if low energy levels c…

This study will test all patients who come to two busy emergency departments in Cape Town, South Africa, for HIV. The goal is to see how many people have HIV or are at high risk and could benefit from a daily pill that prevents HIV (called PrEP). Researchers will then help connec…

This study looks at how small blood vessel disease in the brain develops over time. Researchers will follow 50 people who have had a stroke and at least one risk factor like high blood pressure, high cholesterol, or diabetes. Participants will get three MRI scans over about 15 mo…

This study looks at whether a drink containing ketones (a type of energy source) can change how healthy people breathe, especially during sleep. Twenty volunteers will try the drink and a placebo on different days. The goal is to see if ketones might help with breathing problems …

This study looks at how a small brain area called the cerebellum helps with thinking, not just movement. Researchers will use mild brain stimulation in 50 healthy adults while they do memory and sequencing tasks inside an MRI scanner. The goal is to see if the cerebellum is key f…

This study tests a program called Communities Care, which aims to change harmful social norms that lead to violence against women and girls. About 3,500 adults and adolescents (age 10 and older) in Somalia will take part. Researchers will measure changes in experiences of violenc…

This study checks if very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) are safe for healthy people to take at home. Twenty healthy adults will receive increasing doses and a placebo on different days in a lab, while researchers monitor their bloo…

This study looks at how nicotine pouches affect both cigarette smokers and people who rarely use nicotine. Researchers will measure nicotine levels in the blood and ask participants about their experiences. The goal is to understand the potential risks and appeal of these product…