Institut Bergonié

This study tested a combination of two drugs, durvalumab and tazemetostat, in 164 adults with advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The goal was to see if the combo could shrink or stabilize tumors. This is a disease control approach, not a c…

This study tested a high-precision radiation therapy (helical tomotherapy) at a dose of 54 Gy before surgery in 48 patients with retroperitoneal liposarcoma, a rare cancer in the abdomen. The goal was to reduce the chance of the cancer coming back after surgery. Results showed th…

This study tested a procedure called radiofrequency ablation, which uses heat from a needle to destroy breast tumors, combined with hormone therapy. It included 21 elderly patients (over 70) who either declined or were not candidates for surgery. The main goal was to see if the c…

This study tested a combination of two chemotherapy drugs, trabectedin and cyclophosphamide, in 50 adults with advanced soft-tissue sarcomas that had already been treated. The goal was to find the safest dose and see if the combo could stop the cancer from growing for at least 6 …

This study tested a combination of two drugs (MK3475 and cyclophosphamide) in 129 adults with advanced sarcomas that had spread or could not be removed by surgery. The goal was to see if the treatment could shrink tumors or stop them from growing for at least 6 months. The approa…

This study tested whether adding the drug berzosertib to standard chemotherapy (gemcitabine) can help control a rare soft-tissue cancer called leiomyosarcoma. 58 adults with advanced or spreading disease took part. The goal was to see if the combination could stop or shrink tumor…

This early-phase trial tested a combination of two drugs—trabectedin and durvalumab—in 40 people with advanced soft-tissue sarcoma or ovarian cancer that had not responded to prior treatments. The main goal was to find the safest dose and check for side effects. Researchers also …

This study tested a combination of two immunotherapy drugs, nivolumab and relatlimab, in 68 adults with advanced soft-tissue sarcoma that had spread. The goal was to see if the combo could shrink tumors or stop them from growing for at least 6 months. Participants needed to have …

This study tested a different surgical approach called delayed coloanal anastomosis for people with medium or lower rectal cancer. The goal was to see if it lowers the chance of a dangerous leak where the colon is reconnected, and reduces the need for a temporary or permanent sto…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested the drug pazopanib in 72 adults with progressive desmoid tumors, which are non-cancerous but can be aggressive and hard to treat. The goal was to see if pazopanib could stop the tumors from growing for at least 6 months. The trial measured how many patients rema…

This study looked at whether MRI scans can detect how well breast cancer responds to chemotherapy early in treatment. Sixteen women with infiltrative breast cancer received chemo before surgery and had MRI scans to measure blood vessel changes. The goal was to see if MRI could he…

This study looked at whether an MRI can accurately rule out breast cancer in women who have abnormal nipple discharge (from a single pore, not green or milky) but normal mammogram and ultrasound. About 70 women were enrolled. The goal was to see how often a normal MRI meant no ca…

This study looked at whether adding a blood test (liquid biopsy) to the standard tissue test helps find more EGFR gene mutations in people with advanced non-small cell lung cancer. Over 500 patients who had not yet been treated were tested using both methods. The goal was to see …

This study looked at whether combining a PET scan with a special ultrasound-guided needle biopsy can accurately diagnose cancer in lymph nodes in the chest. 75 adults with suspicious lymph nodes on PET scans were enrolled. The goal was to see if this less invasive method could re…

This study looked at whether giving nitrous oxide (laughing gas) during a spine procedure called vertebroplasty could lower pain and the need for morphine afterward. It included 39 adults who were already taking opioids for more than a month. The goal was to see if the gas could …

This study tested whether a numbing medicine called ropivacaine, placed inside the chest during surgery, can reduce severe pain after lung cancer surgery. 90 adults having lung surgery for cancer took part. The main goal was to see how many patients had major pain when moving aft…

This study tested whether adding ketamine to general anesthesia helps reduce the need for morphine and lowers pain after breast cancer surgery. About 230 adults having mastectomy or lumpectomy took part. The goal was to see if ketamine could make recovery less painful and reduce …

This study looked at whether using telemedicine (video calls), connected watches, and symptom tracking apps can help women with advanced breast cancer who live far from their cancer center. Fifteen women took part, and researchers measured their quality of life after 6 and 12 mon…

This study reviewed medical records of 545 patients aged 12 and older with bone tumors that had spread (metastatic). The goal was to understand what treatments patients actually received outside of clinical trials and how long they lived. The researchers collected information on …

This study tested a questionnaire designed to help doctors and nurses talk about cancer with patients and their caregivers. Researchers checked how consistent and reliable the questionnaire was by recording and scoring interviews. The goal was to create a standard way to understa…

This study looked at whether using a contrast dye during ultrasound, done while surgery is happening, helps surgeons see liver tumors from colorectal cancer more clearly. 68 patients took part. The goal was to see if this extra information changed the surgical plan in a helpful w…

This study created a new statistical method to figure out the right number of participants for clinical trials when patients have different risks or respond differently to treatment. Researchers used data from 500 people in past trials to test their approach. The goal is to make …

This study tested whether FDG-PET CT scans are more accurate than standard CT scans for staging muscle-invasive bladder cancer. Researchers reviewed records of 130 patients who had PET CT scans before surgery. They compared scan results with actual findings from surgery to see ho…

This study looked back at medical records of over 2,100 adults with advanced soft tissue sarcoma to understand how they were treated in everyday practice and how long they lived. Researchers focused on the types and number of treatments patients received, including chemotherapy a…

This study looked at nearly 4,000 people with advanced solid tumors to find out how often their cancers have a specific genetic change called an NTRK fusion. Researchers used advanced DNA and RNA testing on tumor samples to identify these fusions. The goal was to understand how c…

This study tested 526 hospital workers for COVID-19 antibodies to see who had been infected before. Researchers followed up at 3 and 12 months to track how long antibodies lasted. The goal was to learn about immune response in people who work closely with vulnerable patients, lik…

This study examined how age, income, and other factors influence whether elderly cancer patients receive treatment and how long they live. Researchers analyzed data from 450 people aged 65 and older in a French region. The goal was to understand why some seniors get less care and…

This study looked back at the medical records of 492 people with advanced gastrointestinal stromal tumors (GIST) treated in France between 1990 and 2018. The goal was to understand which treatments patients actually received in everyday practice, how many joined other clinical tr…

This study brought together experts to decide what health outcomes matter most when testing cancer treatments in older adults. Instead of focusing only on tumor shrinkage, they identified key areas like independence, memory, mood, and nutrition. The goal is to help future clinica…

This study aimed to find biological markers (biomarkers) that could predict how well the drug trabectedin works in people with advanced soft-tissue sarcomas (excluding certain types). Researchers collected tumor biopsies and blood samples from 29 adult patients to analyze genetic…

This study aimed to objectively measure erectile dysfunction in men three months after treatment for early-stage rectal cancer. Twelve sexually active men were monitored overnight using a device that records erections. The goal was to better understand a common but often undiscus…

This study looked at whether certain genetic differences (polymorphisms) in immune receptors affect how well the cancer drug cetuximab works in people with advanced upper aerodigestive tract cancers. Researchers analyzed DNA from 121 patients to see if these gene variations could…

This study looked at medical records from about 20,000 women with metastatic breast cancer in France. The goal was to see if other measures of treatment success, like time until the cancer gets worse, could replace the standard measure of overall survival. Using real-world data m…

This study looked at 54 women with breast cancer who had surgery under general anesthesia. Some had received a type of chemotherapy called anthracyclines, which can be hard on the heart. Researchers measured a heart stress marker called BNP before, during, and after surgery to se…

This study looked at 631 people with advanced melanoma to see if a measure called 'time to next treatment or death' could replace overall survival in cancer trials. The goal was to find a faster way to tell if a treatment works. The study did not test a new treatment but instead …

This study looked at 228 women with ductal carcinoma in situ (DCIS) or micro-invasive breast cancer who needed a mastectomy. The goal was to see if doing a sentinel lymph node biopsy before mastectomy could help some women avoid a more extensive lymph node removal later. The resu…