Institut Bergonié

This study is for people with a certain type of prostate cancer that is not too advanced but has some higher-risk features. It tests whether adding a short course of the drug darolutamide to standard radiation therapy can lower PSA levels to a very low target (0.1 ng/mL or less) …

This study is testing whether combining an immunotherapy drug (atezolizumab) with an immune booster (BDB001) and targeted radiation can help control advanced solid tumors, including pancreatic, lung, bladder, and breast cancers. About 247 adults with these cancers will receive th…

This study tests whether giving extra chemotherapy before surgery can help prevent the spread of a rare cancer called soft-tissue sarcoma. It is for people with high-risk tumors that can be removed. The goal is to see if the stronger chemo plan keeps cancer from coming back in ot…

This study tests two drugs, pembrolizumab and cabozantinib, in people with advanced sarcomas (cancers of the soft tissue or bone) that have spread or cannot be removed by surgery. The goal is to see if the combination can stop the cancer from growing for at least 6 months. About …

This study tests whether adding a procedure that freezes and destroys a tumor (cryoablation) to standard immunotherapy and chemotherapy helps people with advanced lung adenocarcinoma live longer. About 214 participants will be randomly assigned to receive either the standard drug…

This study tests whether high-intensity focused ultrasound (HIFU) can destroy breast tumors without surgery. Fifteen women with small, early-stage breast cancers will receive HIFU before their planned surgery. The main goal is to see if the ultrasound completely kills the tumor c…

This study looks at certain proteins called convertases in pancreatic tumor samples from 50 patients. Researchers want to see if the levels of these proteins are linked to the immune cells around the tumor. The goal is to find new ways to predict how the disease will progress, no…

This study aims to find specific genetic changes in the tumors of 10,000 adults with advanced solid or blood cancers. By analyzing tumor DNA and immune markers, researchers hope to match each patient with a targeted drug or clinical trial that may work best for their unique cance…

This study is testing whether looking for tumor DNA in the blood can help predict if breast cancer will return in patients who had chemotherapy before surgery. Researchers will take blood samples over time from 180 people whose tumors did not fully disappear after chemo. The goal…

This study looks at how much radiation reaches tumors and healthy organs during a treatment called 177Lu-PSMA-617 for advanced prostate cancer that has spread. Researchers want to see if the radiation dose can predict how well the treatment works and what side effects might occur…

This study looks at whether adding a simple blood test that detects tumor DNA (ctDNA) to regular scans can help doctors choose better treatments for people with advanced colorectal or non-small cell lung cancer. About 332 adults with cancer that has spread will be randomly assign…

This study is developing artificial intelligence (AI) models to help pathologists classify and predict the behavior of rare uterine smooth muscle tumors, including those that are hard to diagnose (STUMP). Researchers will train the AI on digital images of tumor tissue from about …

This study is creating a large national database in France to collect medical and biological information from people diagnosed with sarcoma, a rare type of cancer. By gathering data from up to 150,000 participants, researchers hope to better understand how sarcomas are treated an…