Centre Hospitalier Universitaire Dijon

This study tests whether giving additional chemotherapy to people with stage III colorectal cancer who still have cancer DNA in their blood after standard treatment can prevent the cancer from coming back. About 1,660 participants will be randomly assigned to receive either FOLFI…

This study tests whether giving a drug called argipressin early, along with standard treatment, can help ICU patients with a severe type of shock that doesn't respond to usual medications. About 390 adults will be randomly assigned to receive either argipressin or a placebo. The …

This study tests whether a mild electrical current applied to the scalp (tDCS) can reduce the urge to play internet games in people with pathological gaming disorder. Fifty participants will receive either real or fake stimulation over five sessions. Researchers will measure chan…

This study tests whether a daily pill made from bacterial proteins (OM-89) can reduce the number of antibiotics needed for urinary tract infections in adults with neurogenic bladder who use catheters. About 110 participants will receive either OM-89 or a placebo for one year. The…

This phase 2 trial tests alpelisib, a drug originally developed for cancer, in 20 people aged 2 to 40 with MCAP syndrome—a rare condition causing an enlarged brain, blood vessel issues, and developmental delays. Participants receive either alpelisib or a placebo for 6 months, the…

This study tests a weekly injection of semaglutide (a GLP-1 drug) in 76 adults with 'double diabetes' — a mix of type 1 diabetes and inherited insulin resistance. The goal is to see if the drug improves blood sugar control and helps with weight loss. Participants must be over 18,…

This study tests a new ventilation strategy for patients with a specific type of acute respiratory distress syndrome (ARDS) called focal ARDS. The strategy uses lung ultrasound to guide ventilator settings, early prone positioning, and adjustments based on body mass index. The go…

This study tests whether a chemotherapy regimen called mFOLFIRINOX works better than the standard platinum-etoposide combination for people with a rare, fast-growing type of neuroendocrine cancer that has spread. About 218 adults with this cancer will be randomly assigned to one …

This study looks at whether a blood test for a protein called hPG80 can help find neuroendocrine tumors (NETs) earlier in people with MEN1, a genetic condition that raises tumor risk. About 297 participants with MEN1 will give blood samples, which will be compared to standard ima…

This study looks at whether ultrasound can help find swallowing problems early in ICU patients who are on a breathing machine. Swallowing issues are common after the breathing tube is removed and can lead to lung infections or longer hospital stays. Researchers will use ultrasoun…

This study is testing a new device that mimics a blood vessel to evaluate how well a person's blood clots under realistic flow conditions. Researchers will compare results from healthy donors, patients with von Willebrand disease, and those on antiplatelet drugs. The goal is to s…

This study explores whether a simple, non-invasive eye scan (OCT-A) can diagnose microvascular angina, a heart condition affecting about 112 million people worldwide. Currently, diagnosis requires an invasive heart procedure to measure microcirculatory resistance. Researchers wil…

This study compares three common blood tests—fasting blood sugar, sugar load test, and HbA1c—to see which one is best at detecting diabetes caused by long-term steroid use. Researchers will enroll 75 non-diabetic adults who need steroids for more than three months. The goal is to…

This pilot study is testing whether measuring a protein called thrombomodulin in the blood can help rule out giant cell arteritis (GCA) in people with polymyalgia rheumatica (PMR). GCA is a serious inflammation of the arteries that can cause blindness or stroke if not treated. Th…

This study tests whether taking blood thinners for 12 weeks can prevent dangerous blood clots in people with autoimmune hemolytic anemia (AIHA), a rare disease where the immune system destroys red blood cells. About 72 adults with newly diagnosed or relapsed AIHA will receive eit…

This study tests whether lithium carbonate can improve behavior and thinking in people with a rare genetic disorder caused by changes in the TBR1 gene. Twelve participants aged 6 and older will take lithium for 24 months after a 6-12 month observation period. The goal is to see i…

This pilot study tests a smartphone app called eMind that delivers an 8-week mindfulness programme to help smokers quit. Researchers want to see if smokers find the app acceptable and easy to use. The study involves 40 adult smokers motivated to quit, who will use the app and pro…

This study tests whether virtual reality (VR) can improve movement in elderly people with Psychomotor Disadaptation Syndrome, a condition that affects balance and walking. Fifty hospitalized patients will either receive standard rehab or VR sessions three times a week. The goal i…

This study tests whether gentle muscle vibration can prevent or reduce spasticity (muscle stiffness) in people who recently had a stroke. The trial has two phases: first, it validates a measurement tool, then it compares vibration therapy to a placebo in 100 patients. The goal is…

This study tests whether adding motor imagery (mentally rehearsing movements) to a standard 3-week rehab program helps people with chronic low back pain. 72 adults will be randomly assigned to receive either the rehab alone or rehab plus motor imagery sessions. Researchers will m…

This study compares two methods to help anxious patients complete an MRI scan: an infotainment system (like a TV) or hypnosis. Researchers will enroll 50 adults who feel unexpectedly anxious before a brain MRI. The goal is to see which approach helps patients stay calm enough to …

This pilot study aims to see if it is feasible and acceptable to use genome sequencing to screen newborns for rare diseases in France. Researchers will offer the test to parents of 2,500 newborns across five hospitals, targeting treatable and actionable genetic conditions. The st…

This study looks at how to reduce the long and frustrating journey to a diagnosis for people with developmental abnormalities. Researchers will review past cases, collect new blood or skin samples, and use advanced genetic testing. The goal is to understand why some people remain…

This study looks at whether listening to music with a steady beat can improve how older adults with age-related hearing loss process sentences. Researchers will have 55 participants aged 70 or older listen to regular or irregular rhythm music, then judge if sentences are grammati…

This study looks at whether changes in smell and taste contribute to poor nutrition in people with ALS. Researchers will measure food preferences in 60 adults with ALS using a computer test. The goal is to find new ways to improve diet and quality of life by personalizing food ad…

This study looks at whether improving blood sugar control in people with type 1 diabetes can restore the normal function of HDL, or 'good' cholesterol. Researchers will compare 80 patients with poorly controlled diabetes who receive standard intensive therapy to 63 healthy people…

This study is testing whether a smartphone app can accurately measure how children with cerebral palsy move, like jumping and walking. Researchers will compare the app's results with standard motion-capture systems. The goal is to make it easier and cheaper to assess motor skills…

This study tests whether small wearable sensors (called IMUs) placed in shoes and on the body can accurately measure how children walk. Researchers will first check the sensors in healthy children aged 7–17, then in children with cerebral palsy who can walk without aids. The goal…

This study looks at how people with lower limb amputations naturally adjust their walking before going up or down slopes and stairs. Researchers will use machine learning to analyze these movement patterns. The goal is to create smarter prosthetic legs that can anticipate changes…

This study looks at whether quick, easy walking tests can replace the current complex and time-consuming exam used to track walking problems in people with facioscapulohumeral muscular dystrophy (FSH). Researchers will compare results from simple tests like the 6-minute walk with…

This study looks at how cancer and its treatments change a person's sense of taste and smell, and how that affects their eating and nutrition. Researchers will follow 306 people newly diagnosed with cancer of the mouth, throat, colon, or liver. They will use questionnaires, taste…

This study looks at whether a simple leg-raising test, combined with ultrasound, can help doctors predict how well ICU patients will handle extra fluids. Giving too much fluid can cause harm, so finding a better way to guide treatment is important. The study will involve 100 adul…

This study looks at psychiatric symptoms in people with White-Sutton syndrome, a rare genetic condition. Researchers will interview 30 children and adults and use standard questionnaires to identify anxiety, OCD, autism, and other issues. The goal is to better understand these sy…

This study looks at skin cells called fibroblasts from people with scleroderma and healthy volunteers. Researchers want to find which genes are turned on or off in these cells, especially those linked to aging and inflammation. The goal is to better understand what causes the dis…

Cerebellar ataxias are rare brain disorders that affect coordination. Standard genetic tests leave about 40% of patients without a clear cause. This study will use a newer, long-read DNA sequencing technique on blood samples from 210 patients and their relatives to see if it can …

This study is testing whether a special heart MRI can measure scarring in the left atrium, which might lead to atrial fibrillation. Researchers will enroll 100 people who had a stroke with no clear cause and who are already scheduled to get an implantable heart monitor. The goal …

This study is looking at 200 people who need surgery for an ascending aortic aneurysm. Researchers will use MRI scans before surgery and test the removed tissue in the lab to learn more about the aorta's strength and flexibility. The goal is to better understand when surgery is n…

This study aims to build a digital twin—a computer model—for 400 people with chronic aortic dissection (a tear in the aorta). The model will combine imaging, blood flow, and other factors to better predict if an aneurysm will form and need surgery. The goal is to improve monitori…

This study aims to find new genes or genetic changes that cause rare diseases. Researchers will study 850 people, including patients with suspected genetic rare diseases, fetuses with developmental problems, and healthy relatives. By using advanced DNA sequencing, they hope to gi…

This study follows 100 people taking newer BTK inhibitor drugs (acalabrutinib or zanubrutinib) for blood cancers like leukemia or lymphoma. Researchers want to see how often these drugs cause high blood pressure or heart rhythm problems, and find early warning signs. Participants…

This study looks at how a person's financial and social situation affects their recovery after a stay in the intensive care unit (ICU). Researchers will follow 180 patients who had severe breathing problems or shock, checking for physical, mental, and thinking problems known as P…

This study tests whether a different blood thinner (BAPA) works better than the standard one (citrate) for platelet function tests. Researchers will take three extra blood samples from 100 adults already having a PFA test. The goal is to see if BAPA reduces technical problems and…

This study looks at why some premature babies develop retinopathy of prematurity (ROP), an eye condition that can affect vision. Researchers think fatty acids from the mother may play a role. They will collect blood, placenta, and cord samples from 135 mothers and their preterm o…

This study looks at how age-related changes in thinking skills, like memory and planning, affect movement and increase fall risk. Researchers will test arm and balance tasks in 684 adults aged 55 and older, including those with mild cognitive issues. The goal is to better underst…

This study looks at whether nighttime low blood sugar (hypoglycemia) is linked to muscle loss (sarcopenia) in people with cirrhosis. Researchers will use a continuous glucose monitor for 14 days and measure muscle strength and mass. The goal is to understand this connection bette…

This study looks at whether the quality and function of HDL (often called 'good' cholesterol) is different in people with depression compared to healthy controls. Researchers will analyze blood samples from 90 adults with moderate to severe depression and a control group. The goa…