Centre Hospitalier Universitaire Dijon

This study tested whether adding a sedative drug called dexmedetomidine could help patients with severe septic shock, a life-threatening condition where blood pressure drops dangerously low and doesn't respond to standard medications. The goal was to see if this drug could improv…

This study tested whether a 6-month dental health education program could improve oral hygiene and quality of life for people with schizophrenia. The program taught patients about dental care and was compared to standard monitoring. Researchers followed 79 patients for 12 months …

This study tested whether aflibercept eye injections could reduce swelling in the retina caused by a rare eye disease called Macular Telangiectasia Type 1. It was a Phase 3 trial that planned to compare the drug against a placebo injection in 16 participants over 6 months. The tr…

This study tested whether a drug called levosimendan could help patients with severe heart failure safely stop using a temporary heart-lung machine (ECLS). The drug is meant to strengthen the heart's pumping ability. Researchers compared the drug to a placebo in 82 patients to se…

This study tested if liraglutide, a medication for type 2 diabetes, could reduce fat buildup in the liver and improve cholesterol levels. It involved 127 adults with type 2 diabetes who took the drug for six months. Researchers used special scans and blood tests to measure change…

This study aimed to find out if starting dialysis treatment early or waiting a bit longer leads to better survival for ICU patients with septic shock and sudden, severe kidney failure. It involved 500 critically ill adults and directly compared starting dialysis within 12 hours v…

This study tested whether giving a single dose of a steroid (methylprednisolone) right before elective colon or rectal surgery could reduce serious complications afterward. It involved 78 adults having planned surgery for conditions like cancer or diverticulitis. The goal was to …

This early-phase trial tested a drug called taselisib in people with rare, often severe, genetic overgrowth conditions. The goal was to see if the drug, which targets a specific genetic mutation, could safely control the abnormal tissue growth. The study was small and terminated …

This study tested whether a mindfulness meditation program could help reduce stress and related body inflammation in people caring for family members with severe psychiatric disorders like schizophrenia or bipolar disorder. Caregivers were randomly assigned to either attend mindf…

This study aimed to find new ways to predict how colorectal cancer will progress by looking at tiny particles called exosomes in the blood. Researchers analyzed stored blood samples from 172 patients to see if specific markers within these particles could indicate a patient's sur…

This study aimed to understand how the diabetes medication liraglutide (Victoza®) changes eating behavior in people with type 2 diabetes. Researchers compared three groups: patients starting the drug, similar patients not on the drug, and healthy volunteers. They measured changes…

This study aimed to understand if a person's personality type is linked to biological signs of stress and aging in people with diabetes. Researchers compared 'impatient' (Type A) and 'calm' (Type B) individuals by asking questions and taking a single blood sample. The goal was to…

This study aimed to better understand and detect heart complications, particularly irregular heartbeat (atrial fibrillation), in cancer patients taking the medication ibrutinib. It followed a small group of 8 patients starting ibrutinib treatment, using special tests to try to pr…

This study aimed to test a new scoring system that predicts how well a patient's vision will recover one year after a combined eye surgery. The surgery removes both a cataract and a thin scar tissue (epiretinal membrane) from the retina. Researchers tested the score on patients t…

This study aimed to understand how mechanical ventilators (breathing machines) might damage the energy-producing parts of immune cells in the lungs of patients with severe pneumonia and breathing failure. Researchers planned to compare cells from 28 patients on ventilators with t…

This study tested a special light scanner (NIRS) to see if it could better predict how well a leg stump heals after amputation. It involved 62 people who had a below-the-knee amputation due to poor circulation. Researchers compared the new scanner to the current standard method t…