Centre Hospitalier Universitaire Dijon

This study investigated whether a class of diabetes medications called GLP-1 agonists can reduce harmful fat deposits inside the heart muscle of people with type 2 diabetes. Researchers used MRI scans to measure heart fat in 42 adult patients before and after 6 months of starting…

This completed Phase 3 trial tested whether using PET scans early in treatment could help personalize chemotherapy for advanced Hodgkin lymphoma. Patients were randomly assigned to either receive standard chemotherapy or have their treatment adjusted based on their PET scan resul…

This study tested whether using magnetic pulses on the brain could help people quit smoking and avoid relapse. It involved 88 adult smokers who had previously failed to quit using standard medications. Researchers compared different patterns of brain stimulation to see which was …

This study tested whether adding a cholesterol-lowering drug (pravastatin) to the standard liver cancer drug sorafenib could help patients live longer. It involved 474 adults with advanced liver cancer who were not candidates for surgery or other curative treatments. The main goa…

This study compared two different treatment approaches for a serious complication of age-related macular degeneration (AMD): sudden bleeding under the center of the retina. It involved 91 patients who experienced this type of eye bleed. Researchers randomly assigned patients to e…

This study followed patients in France who received a special drug-coated balloon treatment for blocked arteries in their upper leg. The goal was to see if this procedure improved their ability to walk and reduced their pain one year after treatment. Researchers collected real-wo…

This study looked at whether medication solutions used to keep dialysis catheters clean might accidentally leak into patients' bloodstreams. Researchers measured blood changes in 76 adults with sudden kidney failure who needed dialysis. The goal was to understand potential safety…

This study tested whether using a special blood test that measures carbon dioxide (CO2) levels could help doctors better treat critically ill patients in shock. The goal was to see if this CO2-guided approach was more effective at lowering high lactate levels—a sign of severe str…

This study looked at a device that automatically ties knots during heart valve replacement or repair surgery. The goal was to see if using this device could make the surgery faster and safer by reducing the time the heart is stopped. Researchers collected data from 557 adult pati…

This study compared two different anesthesia methods during scheduled heart valve replacement surgery to see which better protects the heart muscle from stress and damage. Researchers measured troponin levels (a marker of heart stress) in 82 patients who received either sevoflura…

This small, completed study tested a new approach to help heavy smokers quit. It combined standard nicotine patches with a gentle, non-invasive brain stimulation technique called rTMS. The goal was to see if stimulating a specific brain area could reduce cravings in people who ha…

This study tested if a special, intensive follow-up program could help people better manage their health after a stroke or heart attack. It compared care from a team of nurses, doctors, and pharmacists working together to the usual follow-up care patients receive. The main goal w…

This study tested a new computer program to fine-tune cochlear implants for people who also use a hearing aid in their other ear. The goal was to improve how well participants could understand speech, especially in noisy places. The study involved 18 adults who had used their coc…

This early-stage study tested a new way to deliver chemotherapy directly to liver tumors in patients with inoperable liver cancer and cirrhosis. Researchers injected a drug called idarubicin mixed with an oily substance (lipiodol) into the artery feeding the liver, hoping it woul…

This small, completed pilot study tested a new idea: using a special full-body compression bandage on ICU patients with severe sepsis or septic shock. The goal was to see if the gentle pressure could help the body reabsorb dangerous excess fluid that builds up during treatment, p…

This study compared two ways of delivering laser treatment for diabetic eye disease. Researchers tested whether doing all the laser treatment in one session was as safe and effective as spreading it over four sessions. They measured eye swelling and vision changes in 83 patients …

This study tested a new heating cable designed to warm chemotherapy fluid inside the abdomen during cancer treatment. The goal was to see if this simpler method could safely replace complex external heating systems. Thirteen patients scheduled for a specific type of heated abdomi…

This study tested whether the drug sirolimus could stop the progression of abnormal, excessive growth in specific body parts of people with a genetic condition called PIK3CA-related overgrowth. Sixteen participants, aged 3 to 65, took sirolimus for six months after a six-month mo…

This study tested whether a citrate solution works better than the standard heparin solution at keeping dialysis catheters from clogging or causing infections in ICU patients with sudden kidney failure. It involved 405 hospitalized adults who needed temporary dialysis. Researcher…

This study aimed to find a better way to detect dangerous infections early after planned colon surgery. Researchers compared two blood tests—C-reactive protein (CRP) and procalcitonin (PCT)—to see which could spot infections sooner, as early as the second day after surgery. The g…

This pilot study tested a new system to catch dangerous internal leaks early after colon cancer surgery. Researchers monitored patients' CRP (a marker of inflammation in the blood) in the days after their operation. If CRP levels were high, doctors followed a specific plan to qui…

This study aimed to find a better way to detect a serious complication called a pancreatic fistula after pancreas surgery. Researchers tested whether measuring an enzyme called lipase in patients' surgical drains could predict these leaks more accurately than the current standard…

This study tested whether a faster, more comprehensive genetic test could be used during pregnancy when ultrasound scans show potential problems. It involved 149 pregnant women and their partners to see if this new test could provide clearer answers about the cause of the abnorma…

This study tested a new cognitive assessment tool called CASP, designed specifically for stroke patients who have trouble speaking or understanding language (aphasia). The goal was to see if doctors could reliably use this 15-minute test to check memory, thinking, and other brain…

This study tested a new, faster genetic test for pregnant couples whose ultrasound shows a potential fetal abnormality. It compared a rapid, one-week genetic test against standard tests that can take a month, to see if it could find a cause for the abnormality just as well but mu…

This small pilot study tested whether a new, advanced genetic sequencing method could find the cause of severe childhood epilepsy when standard tests fail. It involved 15 children with unexplained epilepsy and developmental delays. The goal was to see if this method could provide…

This study tested whether a new, advanced DNA test could find the cause when a fetus has multiple serious malformations and standard exams fail. Researchers performed this test on 100 fetuses with at least two malformations, along with blood samples from both parents, to see if i…

This study tested if a PET/CT scan could accurately diagnose giant cell arteritis (GCA), a common artery inflammation in people over 50. It compared the scan's accuracy to other imaging tests and the current standard, which is an invasive biopsy. The goal was to find a less painf…

This study tested a method to better manage pain after open-heart surgery. Researchers gave 160 patients a local anesthetic mix through a small tube placed near the surgical wound. The goal was to see if this approach could reduce the need for strong opioid painkillers like morph…

This study tested a new approach to anesthesia for heart surgery that avoids using morphine or similar opioid painkillers. Researchers wanted to see if this 'opioid-free' method could reduce the need for strong painkillers after surgery and help patients recover better with fewer…

This study tested whether Korean manupuncture, a hand-based acupuncture technique, could reduce pain in women with endometriosis. Seventy-four women with diagnosed endometriosis were randomly assigned to receive either the real hand treatment or a placebo version. The goal was to…

This study tested if using a special device to measure pupil dilation during heart surgery could help anesthesiologists give the right amount of opioid painkiller. Researchers compared 50 patients having planned heart surgery, giving some doctors the pupil measurement tool and ot…

This study tested a new computer program designed to fine-tune the settings of a cochlear implant. It involved 9 adults who use a cochlear implant in one ear and a hearing aid in the other. The goal was to see if the computer's custom settings could improve their ability to hear …

This study looked back at the medical records of over 1,700 adults who had heart surgery to compare two anesthesia methods. It aimed to see if using an opioid-free approach (with a drug called lidocaine) instead of standard opioid-based anesthesia led to fewer complications after…

This study tested whether using virtual reality games on a tablet could help frail older adults in rehabilitation. It compared this fun, game-based training to standard rehab exercises. The goal was to see if the games improved walking, balance, and thinking skills both right aft…

This study looked at whether standard decompression surgery for lumbar spinal stenosis helps improve patients' forward-leaning posture in addition to relieving leg pain. Researchers followed 72 patients who had surgery after other treatments failed, measuring their spinal alignme…

This study tested a new tool called the Clock'N'Test, which aims to detect early emotional disorders by measuring how people estimate time. Researchers showed 150 healthy participants short emotional videos and measured if their sense of time changed afterward. The goal was to es…

This study looked at how COVID-19 lockdowns and hospital fears affected the care of diabetic foot ulcers. Researchers analyzed hospital records from 2017 to 2020 to see if fewer people went to the hospital for foot wounds during lockdowns. They wanted to find out if these delays …

This study looked at whether environmental factors near a person's home affect their health one year after a heart attack. Researchers analyzed data from nearly 1,000 patients to see if air pollution, noise levels, or access to parks and nature influenced their risk of another he…

This study looked at whether stopping feeding before removing breathing tubes in intensive care patients affects stomach contents. Researchers used ultrasound scans to measure stomach volume in 101 ICU patients. The goal was to understand if continuing feeding increases stomach c…

This study compared two advanced embryo incubators used during IVF treatment to see which one helps embryos implant better. Researchers followed 388 women undergoing IVF with a specific sperm injection technique, randomly assigning them to one of the two incubator systems. The ma…

This study aimed to understand how tasting fat in the mouth affects hormone levels in the gut and blood. Researchers compared healthy men, men with type 2 diabetes, and men with obesity to see if their bodies responded differently. The goal was to gather basic knowledge about tas…

This study aimed to understand the biological changes that happen inside the eye during a retinal detachment, a serious eye emergency. Researchers collected and analyzed fluid samples from 137 patients undergoing eye surgery, comparing those with retinal detachment to those with …

This study aimed to understand how people with long-term mental disorders, their caregivers, and healthcare professionals view cardiovascular risk and care. Researchers conducted focus groups with 127 participants across France to gather their experiences and perspectives. The go…

This study aimed to understand why diabetic patients develop more dangerous fatty plaques in their neck arteries. Researchers compared plaque samples from 204 diabetic and non-diabetic patients who were already scheduled for carotid artery surgery. The goal was to identify chemic…

This study looked back at medical records to understand how often serious eye infections happen after common eye injections used to treat vision loss from macular degeneration and diabetes. Researchers analyzed data from over 360,000 French patients who received these injections …

This study aimed to discover new genes responsible for a rare, inherited skin condition called syndromic poikiloderma. Researchers analyzed genetic data from 39 patients who already had the condition. The goal was to improve the accuracy of diagnosis, provide better information f…

This study looked at whether a person's nutritional status when they get sick affects their chance of surviving COVID-19. Researchers followed 426 people aged 70 and older who were hospitalized, comparing those with and without COVID-19. The goal was to see if being undernourishe…

This study aimed to better understand a dangerous lung infection called ventilator-associated pneumonia (VAP) in intensive care patients. Researchers closely examined the sticky layer of germs (biofilm) that forms inside the breathing tubes of 61 patients on ventilators. The goal…

This study aimed to understand how lupus affects people's daily life, energy, and mood over time. Researchers followed 356 adults with lupus, asking them to complete detailed questionnaires about their symptoms and well-being. The goal was to learn what factors most impact qualit…

This study aimed to better understand autoimmune hemolytic anemia (AIHA), a condition where the immune system attacks a person's own red blood cells. Researchers compared the types and behaviors of specific immune cells (T cells) in 27 patients with AIHA to those in healthy volun…

This study observed 748 patients undergoing retina surgery to see if continuing blood thinners (like aspirin or warfarin) increased bleeding risks. Researchers tracked complications for one month to determine if stopping these medications before surgery is necessary. The goal was…

This study aimed to understand how a trusted contact person is chosen for patients in the Intensive Care Unit (ICU). Researchers compared the criteria used by the medical team, the patients themselves, and their close friends or family members. They surveyed 42 participants to id…

This study aimed to see if a bedside lung ultrasound could help doctors identify which patients are at high risk for serious breathing problems after major abdominal or urinary surgery. Researchers followed 165 patients in intensive care after their operations. They used the ultr…

This study aimed to find biological markers in the blood that might indicate physical stress in people with depression. Researchers enrolled 300 people, including those with and without depression, to measure things like telomere length (a cellular aging marker) and oxidative str…

This study tested whether a continuous glucose monitor (Freestyle Libre) could help manage blood sugar in diabetic patients starting chemotherapy. Researchers wanted to see if this device could detect dangerous highs and lows in blood sugar that might affect chemotherapy safety a…

This study aimed to understand if poor nutrition makes foot sores heal slower in people with diabetes. Researchers followed 75 adults with diabetes who had a foot sore for 1 to 24 months. They tracked how many sores healed and checked patients' nutritional status to see if there …

This study compared two approaches to supporting women who have experienced domestic abuse. Researchers followed 67 women who received help either at a specialized center offering medical, social, and legal services or at conventional shelters. They measured symptoms of post-trau…

This study aimed to understand why some people with COVID-19 get much sicker than others. Researchers measured the activity of specific immune cells in 39 hospitalized patients. They wanted to see if a stronger or weaker immune response was linked to the worsening of symptoms.

This study looked back at 198 patients who received a newer, faster-to-implant 'sutureless' aortic valve. The goal was to check if these valves, which are easier for surgeons to put in, cause specific heart rhythm problems after surgery. Researchers reviewed patient records to se…

This study aimed to find immune system markers in a mother's blood that could better predict if a woman hospitalized for threatened preterm labor would actually deliver her baby early. Researchers enrolled 210 women and analyzed specific white blood cells to see if their patterns…

This study aimed to understand why people with poorly controlled Type-1 diabetes often have high cholesterol. Researchers tested if improving blood sugar levels could fix a problem with a specific protein (apoC1) that helps manage cholesterol. They compared blood samples from ove…

This study aimed to understand the dental health of adults with schizophrenia in a specific region of France. Researchers examined the teeth of 110 participants, took a blood sample from some to check vitamin C levels, and asked questions about their dental hygiene and eating hab…

This study aimed to understand the preferences and experiences of families whose children have rare developmental disorders when receiving results from advanced genetic testing. Researchers surveyed and interviewed over 500 parents in France to learn what kind of information they…

This study aimed to understand if the levels of omega-3 fats in a premature baby's blood are connected to the development of an eye condition called retinopathy of prematurity (ROP). Researchers enrolled 62 infants born very early (before 29 weeks) to measure their omega-3 levels…

This French hospital study examined whether patients from economically vulnerable backgrounds experience more severe ICU admissions and poorer recovery outcomes. Researchers followed 1,417 ICU patients to understand how socioeconomic factors affect initial illness severity, survi…

This study aimed to understand how fat metabolism differs between COVID-19 severe pneumonia and pneumonia caused by other germs. Researchers measured cholesterol and other fat-related substances in 62 hospitalized patients to see if these levels relate to obesity, inflammation, a…

This study aimed to understand why some older adults fall by investigating the link between ankle muscle strength and balance. Researchers measured the ankle strength and standing balance of 34 participants aged 60-90, comparing those who had recently fallen to those who had not.…

This study explored how mental health caregivers' personal beliefs and attitudes might help or hinder educational programs for patients with schizophrenia. Researchers interviewed 21 doctors, nurses, and other caregivers in France to understand their views on teaching patients to…

This study looked back at the medical records of 65 patients who suffered a severe cardiac arrest that did not respond to standard CPR and required a heart-lung support machine. The goal was to identify which factors, like the time without blood flow or certain blood test results…

This study looked at whether a simple, non-invasive sensor that uses light (called NIRS) could provide useful information about a common heart condition in very premature babies. Researchers compared the sensor readings to the standard ultrasound exams in 26 babies born before 32…

This study aimed to find out how often elderly people with diabetes living in nursing homes experience low blood sugar (hypoglycemia), which can be dangerous but often goes unnoticed. Researchers monitored 29 residents over 60 years old to measure these events. The goal was to be…

This pilot study explored whether giving water through a feeding tube could be as effective as standard saline IV fluids for boosting blood volume in critically ill ICU patients. Researchers compared the effects of water and saline on heart function and blood pressure in 50 sedat…

This study tested whether using realistic simulations could help adults with insulin-dependent diabetes learn to use the FreeStyle Libre glucose monitor. It involved 27 patients who had already completed a standard education program. Researchers wanted to see if this hands-on, si…

This study looked at whether colorectal cancer patients need continued medical monitoring after five years of being cancer-free. Researchers analyzed data from 598 patients who had their tumors surgically removed with the goal of cure. The goal was to understand how often cancer …

This study aimed to understand if a person's psychological profile is linked to developing foot wounds in type 2 diabetes. Researchers compared 66 people with diabetes and foot wounds to people with diabetes but no wounds. They used a personality questionnaire to see if certain t…

This study aims to understand how immune cells change in people with coronary artery disease (plaque buildup in heart arteries). Researchers compared blood samples from 50 patients with and without artery plaque during heart surgery. The goal is to identify new markers in blood t…

This study aimed to understand why some patients with severe bloodstream infections (sepsis) get worse even while on antibiotics. Researchers measured the energy production in certain immune cells (myeloid cells) from 36 adults in the intensive care unit, comparing those with and…

This study aimed to create and validate a questionnaire to understand how people with schizophrenia perceive their own oral health. Researchers asked 59 adults with long-term schizophrenia to complete several surveys about their mouth, memory, mood, and quality of life. The goal …

This study tested whether a simple, radiation-free ultrasound scan of a patient's thigh and breathing muscles, taken before major heart or lung surgery, could help predict their risk of serious complications after the operation. Researchers enrolled 301 patients aged 65 and older…

This study aimed to understand if a common stroke treatment (rt-PA) changes levels of a brain protein called BDNF in the blood. Researchers measured BDNF in 50 adults who had a recent ischemic stroke. The goal was to see if BDNF levels could be an early sign of how well a patient…

This study aimed to understand the mental health challenges faced by hospital staff during the COVID-19 pandemic and evaluate what support strategies helped them cope. Researchers surveyed over 4,500 hospital professionals to learn about their stress levels, emotional challenges,…

This study looked back at patient records to see if creating a specialized referral center for ECMO treatment improved survival rates. ECMO is a life-support machine for people with severe lung failure. Researchers compared outcomes for 172 patients before and after the specializ…

This study aimed to understand how often a condition called 'venous congestion' (fluid backup) happens in general intensive care patients and how it might be linked to organ problems like kidney or liver failure. Researchers observed 185 adult patients who were newly admitted to …

This study tested a new rocking chair device to see if it could safely stimulate the inner ear's balance system. Researchers wanted to understand how this system works and if problems with it contribute to falls in older people. The study measured participants' eye movements whil…

This study aimed to better understand how the immune system works in people with giant cell arteritis (Horton's disease), a type of blood vessel inflammation. Researchers compared blood samples from 41 patients with the disease to samples from healthy volunteers. They analyzed sp…

This study aimed to understand why obese women might have more difficult labors. Researchers collected cells from 38 women who had C-sections to see how obesity changes the behavior of the uterine muscle cells involved in contractions. The goal was to learn more about the basic b…

This study aimed to find early warning signs that predict major bleeding in critically ill adults using a heart-lung life support machine called VA ECMO. Researchers looked at 278 patients to see which factors at the start of treatment were linked to serious bleeding events. The …

This study aimed to understand why some patients with type 2 diabetes experience an increase in 'bad' cholesterol when taking the medication dapagliflozin. It involved 28 participants who were randomly assigned to take either the drug or a placebo for six months. Researchers trac…

This study looked at how COVID-19 lockdowns in France impacted people with long-term health conditions like heart disease, multiple sclerosis, and cancer. Researchers followed over 1,300 patients to see if lockdowns changed their medication use, lifestyle habits, and access to me…

This study aimed to objectively measure how spinal surgery affects walking ability in patients with lumbar spinal stenosis. Researchers followed 40 adults before and after their scheduled surgery, using a 6-minute walk test to track changes in walking speed. The goal was to provi…

This study tested whether virtual reality (VR) is a safe and practical tool for assessing and potentially improving walking in people with a leg amputation. Researchers had 70 participants, including healthy volunteers and amputees, walk in VR environments simulating flat ground …

This study tested whether a short, fast step exercise is a safe and practical way to measure a specific type of fitness (anaerobic capacity) in people with coronary artery disease. Researchers had 44 patients perform the test to see if they could complete it without complications…

This study aimed to discover the genetic causes of a rare disorder where children are born with very low white blood cells and other developmental differences. Researchers analyzed the genes of 25 participants with this condition to find the specific genes responsible. The goal w…

This study looked at the safety of anti-TNF medications for pregnant women with inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. Researchers analyzed French national health data from over 8,700 pregnancies to understand whether these medications help…

This study aimed to understand if a specific type of immune cell (CD8 T cells) is involved in causing Horton's disease, a condition that causes inflammation in blood vessels, often in the head. Researchers compared blood samples from 30 patients newly diagnosed with the disease t…

This study aimed to understand if the types of fats people eat are linked to their risk of developing colorectal cancer. Researchers compared 551 patients aged 45 and older—some with newly diagnosed colon cancer and some without—by measuring specific fats in their body fat and bl…

This study aimed to understand how common fatigue is after a stroke and what might cause it. Researchers followed 126 stroke patients to see if the treatments they received right after their stroke were linked to later fatigue. The goal was to gather information to help doctors b…

This study followed 202 patients after retinal detachment surgery to understand why some people don't regain good vision. Researchers used advanced eye scans and vision tests over 12 months to see how the eye's physical healing relates to actual vision improvement. The goal was t…

This study looked at how people's social and economic backgrounds affect their recovery from severe COVID-19 lung damage. Researchers followed 543 patients who needed intensive care for COVID-related breathing problems, checking their lung function and quality of life six months …

This small, completed study aimed to understand why dangerous fluid buildup happens in septic shock, a severe and often fatal infection. Researchers compared the makeup of a specific body fluid from 26 sedated patients—some with septic shock and some with other types of shock. Th…

This study tested whether a new, quick eye scan could spot tiny changes in the blood vessels of people with obstructive sleep apnea. Researchers compared eye scans from 166 adults, some with sleep apnea and some without, to see if the scans revealed early signs of damage. The goa…