Centre Hospitalier Universitaire Dijon

This study followed 293 patients in France who received a drug-coated balloon to open blocked leg arteries. The main goal was to see if their walking ability and pain improved one year after the procedure. The results help doctors understand how well this treatment works for peop…

This study tested whether adding the cholesterol-lowering drug pravastatin to the standard cancer drug sorafenib helps people with advanced liver cancer live longer. It included 474 adults with Child-Pugh A cirrhosis whose cancer could not be cured. The main goal was to see if th…

This study tested whether citrate or heparin is better for keeping dialysis catheters working longer in ICU patients with sudden kidney failure. 405 adults were randomly assigned to receive either citrate or heparin as a catheter lock solution. The goal was to see which solution …

This early-stage study tested a chemotherapy drug called idarubicin mixed with a contrast oil (lipiodol) injected directly into the liver artery for people with liver cancer that cannot be removed by surgery. The 15 participants all had cirrhosis. The goal was to find a safe dose…

This study tested whether using an early PET scan after two rounds of chemotherapy can help doctors choose the right treatment for people with advanced Hodgkin lymphoma. Patients whose scan showed a good response got a milder chemo, while those with less response continued strong…

This study looked at 83 people with diabetes and early-stage eye disease. It compared having laser treatment in one session versus four sessions to see which approach better controls the disease and reduces the risk of swelling in the center of the eye. The main goal was to measu…

This study tested whether the anesthetic sevoflurane protects the heart better than propofol during aortic valve replacement surgery. 82 patients were randomly assigned to receive either sevoflurane or propofol during and after surgery. The researchers measured troponin levels, a…

This study tested whether using a CO2-based algorithm to guide treatment of high lactate in patients with acute circulatory failure works better than standard care. 180 adults in intensive care were randomly assigned to either usual treatment or treatment guided by CO2 measuremen…

This study tested whether intensive, coordinated follow-up by nurses, doctors, and pharmacists over two years helps people recover better after a stroke or heart attack compared to standard care. Researchers enrolled 859 participants and measured quality of life and healthcare co…

This pilot study tested the drug sirolimus in 16 people aged 3 to 65 who have excessive growth in parts of their body due to a change in the PIK3CA gene. The goal was to see if sirolimus can stop or slow that overgrowth. Researchers used MRI scans and other measures to track chan…

This study tested whether a powerful genetic test called exome sequencing can find the cause of severe epilepsy in children when standard tests fail. Researchers studied 15 children with epileptic encephalopathy of unknown genetic origin. The goal was to see if this test could im…

This study tested a new thinking test called CASP for stroke patients. The test is designed to work even for patients who have trouble speaking after a stroke. Researchers checked how well the test works by comparing it to other tests in 263 patients.

This study looked at whether a PET/CT scan of the head arteries can accurately diagnose giant cell arteritis, a type of blood vessel inflammation. Researchers compared the scan results to those from ultrasound and MRI in 70 patients suspected of having the condition. The goal was…

This study tested whether transcranial magnetic stimulation (TMS) can help smokers quit by reducing cravings and preventing relapse. 88 adults who had failed previous quit attempts received daily TMS sessions for a week, followed by maintenance sessions. The goal was to see if th…

This study tested whether playing virtual reality and tablet-based games could improve motor and thinking skills in frail elderly people during rehabilitation. Thirty-seven participants aged 65 and older took part. The goal was to see if this fun, game-based training works better…

This study tested Korean manupuncture, a hand-based therapy, for reducing pain in women with endometriosis. 74 women were randomly assigned to receive either real or placebo sessions. The goal was to see if this gentle, non-drug approach could help manage pain that often doesn't …

This study tested whether a whole-body compression bandage could help reduce fluid buildup in ICU patients with severe sepsis or septic shock. 64 patients on mechanical ventilation received the bandage within 12 hours of admission. Researchers tracked daily fluid balance and chec…

This study looked at whether a computer algorithm could improve how a cochlear implant is set for people who have one implant and a hearing aid in the other ear. Nine adults with severe hearing loss took part. The goal was to see if the new settings helped them hear better in qui…

This study tested whether adding a tramadol injection to a continuous local anesthetic (levobupivacaine) delivered through a wound catheter can reduce the need for morphine after heart surgery via sternotomy. 160 adults undergoing various heart surgeries were enrolled. The goal w…

This study tested whether a non-invasive brain stimulation technique called rTMS could reduce tobacco cravings in heavy smokers who had already failed multiple quit attempts. 39 highly nicotine-dependent adults received either real or fake rTMS to a brain region linked to craving…

This study tested whether using a combination of lidocaine, ketamine, and dexamethasone instead of opioids during heart surgery could lower the need for morphine afterward and reduce complications. 110 adults having heart surgery with a heart-lung machine took part. The goal was …

This study tested a new way to adjust cochlear implants for people who are deaf in one ear but have some hearing in the other. Researchers used an evolutionary algorithm to customize the frequency settings of the implant. The goal was to help participants understand speech better…

This completed study from Dijon University Hospital followed 60 parents of infants at high risk for cerebral palsy after NICU discharge. Researchers measured parental stress and healthcare use at 4, 9, and 24 months corrected age using questionnaires. The goal was to understand h…

This study measured levels of a brain protein called BDNF in 50 stroke patients who received a clot-busting drug. Researchers wanted to see if BDNF levels rise after treatment and if they could help predict recovery of movement, thinking, and mood three months later. The goal is …

This study followed 356 adults with lupus over time to see how the disease impacts their quality of life. Participants filled out questionnaires about their symptoms, fatigue, mood, and daily activities. The goal was to better understand what factors affect well-being in lupus, w…

This study used advanced genetic sequencing to find new genes responsible for syndromic poikiloderma, a rare condition affecting skin and other organs. Researchers analyzed DNA from 39 patients to improve diagnosis, genetic counseling, and tumor risk monitoring. The goal is to he…

This study looked for new genes that cause a rare condition called syndromic congenital neutropenia, where children are born with low infection-fighting white blood cells and other developmental issues. Researchers used advanced gene sequencing on 25 participants to find the gene…

This study looked at whether a type of immune cell called T CD8 plays a role in Horton's disease, a condition that causes inflammation in blood vessels. Researchers took extra blood samples and performed standard tests on 30 newly diagnosed patients to measure these immune cells.…

This study looks at whether heparin or citrate locks used in dialysis catheters leak into the bloodstream. It involves 76 adults with acute kidney failure. Researchers measure blood clotting and calcium levels before and after injecting the lock to check for leakage and potential…

This completed study looked at over 4 million hospital records of children aged 0 to 5 in France to estimate how often physical abuse occurs and what factors are linked to it. Researchers used existing national databases to identify cases with confirmed or suspected abuse codes. …

This study looked at 598 people who had surgery to remove colorectal cancer with the goal of curing it. Researchers wanted to understand how often the cancer comes back after five years and where it returns. The goal is to use this information to create better follow-up care plan…

This study aims to develop and validate a test that uses time estimation to reveal emotional disorders in people with neurological diseases. Researchers first need to establish normal reference values in 150 healthy adults aged 20 to 92. The test measures how emotional video clip…

This study analyzed data from over 8,700 pregnant women with inflammatory bowel disease (Crohn's or ulcerative colitis) to see how well doctors follow guidelines when prescribing antiTNFα drugs and whether the benefits outweigh the risks for both mother and baby. Researchers look…

This study looks at why dapagliflozin, a diabetes drug, can raise 'bad' cholesterol levels. Researchers will track how the body makes and clears cholesterol in 28 adults with type 2 diabetes over 6 months. Half the participants will get dapagliflozin, the other half a placebo. Th…

This completed pilot study looked at whether a quick, non-invasive eye scan (OCT angiography) can detect early blood vessel changes in the retina of people with obstructive sleep apnea. Researchers compared 166 adults with and without sleep apnea. The goal was to see if retinal i…

This study looked at how a person's social and economic situation affects their health when they are admitted to an intensive care unit (ICU). Researchers followed 1,417 patients in France to see if those with fewer resources had more severe illness at admission and worse outcome…

This study looked at 91 people with a type of bleeding in the eye caused by age-related macular degeneration (AMD). It compared two treatments: surgery followed by anti-VEGF injections, or a gas injection followed by anti-VEGF injections. The goal was to see which approach helps …

This study looked at 300 people to see if depression causes changes in blood cells that show signs of early aging and stress. Researchers measured telomere length and oxidative stress levels to find genetic markers that could help doctors understand how severe a person's depressi…

This study looked at the dental health of 110 adults with schizophrenia in Côte d'Or, France. Participants received a mouth exam, a blood test for vitamin C levels, and answered a 30-minute questionnaire about their dental care and eating habits. The goal was to understand their …

This study tested a special heating cable (Thermowire) to warm chemotherapy liquid directly inside the body during surgery for abdominal cancers. The goal was to see if this method is safe and works well, possibly replacing bulky external pumps. 13 adults scheduled for heated che…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study looked back at medical records of 65 adults who had a cardiac arrest that did not respond to usual treatments and were placed on a heart-lung machine (ECLS). The goal was to find factors that might help predict who is more likely to survive. Researchers checked things …

This study looked at how tasting fatty acids (like linoleic acid) changes levels of gut hormones in healthy people, those with type 2 diabetes, and obese individuals without diabetes. Researchers measured hormone levels in blood after oral stimulation and compared taste sensitivi…

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at 552 adults who had planned colorectal surgery to see if a blood test called procalcitonin (PCT) could detect infections earlier than the standard C-reactive protein (CRP) test. The goal was to find infections by day 2 after surgery instead of waiting 5-7 days…

This study explored whether malnutrition makes it harder for foot sores to heal in people with diabetes. Researchers followed 75 patients with type 1 or 2 diabetes who had a foot sore for 1 to 24 months. They measured how many sores healed and checked for signs of malnutrition. T…

This study looked at whether things like air pollution, noise, and access to parks or water near your home affect how well people recover one year after a heart attack. Researchers followed nearly 1,000 patients from the Dijon area who had a heart attack between 2002 and 2008. Th…

This study looked at whether eating certain fats (polyunsaturated fatty acids) is linked to colorectal cancer risk. Researchers measured fatty acids in fat tissue and blood samples from 551 people with and without colorectal cancer. The goal was to find reliable biomarkers that c…

This study looked back at 198 patients who had a sutureless aortic valve replacement to see how often they developed heart rhythm problems. These newer valves are faster to implant but have a metal frame that might affect the heart's electrical system. The goal was to better unde…

This study looked at 202 people who had surgery for retinal detachment, a condition where the light-sensitive layer at the back of the eye pulls away. Researchers used high-resolution eye scans and vision tests to see how the eye heals over a year. The goal was to better understa…

This study looked back at the records of 1772 adults who had heart surgery with a heart-lung machine. It compared those who received standard opioid painkillers to those who got an opioid-free approach using lidocaine. The goal was to see if avoiding opioids led to fewer complica…

This study tested whether a powerful DNA test called high-throughput exome sequencing can find genetic causes of multiple birth defects in fetuses when standard exams fail. Researchers studied 100 fetuses with at least two malformations and no prior diagnosis. They compared the n…

This study looked at how certain immune cells, called T cells, behave in people with autoimmune hemolytic anemia, a condition where the body attacks its own red blood cells. Researchers compared blood samples from 27 patients and healthy volunteers to understand the disease bette…

This study looked at how obesity might affect the cells in the uterus that help with labor. Researchers took blood and uterine tissue samples from 38 women having C-sections, some with normal weight and some obese. They wanted to see if certain cells and chemicals in the blood co…

This study looked at how patients in the ICU, their family members, and healthcare teams decide who should be the contact person. The goal was to see if these groups use different criteria. Researchers surveyed 42 people to compare their views. The findings could help improve how…

This study looked at 210 pregnant women hospitalized for preterm labor between 24 and 34 weeks. Researchers measured specific immune cells in their blood to see if these could predict whether they would deliver within 7 days. The goal is to find a more accurate way to identify wo…

This study tested a new questionnaire to measure how people with schizophrenia perceive their own oral health. Researchers enrolled 59 patients who completed surveys about their oral health and quality of life. The goal is to create a reliable tool to guide better dental preventi…

This study looked at 126 people who recently had a stroke caused by a blocked blood vessel in the brain. Researchers wanted to find out how common fatigue is after a stroke and what factors might be linked to it, including any treatments given in the first days. Participants comp…

This study looked at 72 people with lumbar stenosis who had decompression surgery to relieve leg and back pain. Researchers wanted to see if the surgery also improved their posture, specifically a forward-leaning stance. They used special X-ray imaging to measure changes in spine…

This study looked at whether improving blood sugar control can restore a protein called apoC1, which helps reduce bad cholesterol. Researchers compared 160 type-1 diabetes patients with poor blood sugar control to 80 healthy controls. They took blood samples to measure how well a…

This study tested a special rocking chair designed to stimulate the body's balance system (vestibular system) in 30 adults. The goal was to see if the chair could make people feel movement and cause specific eye reflexes, helping researchers understand balance problems that lead …

This study looked at blood samples from 41 people with giant cell arteritis (Horton's disease), a condition that causes inflammation in blood vessels. Researchers examined specific immune cells called regulatory T cells to see if they are defective in this disease. The goal is to…

This study tested a step-by-step plan for patients who had high C-reactive protein (CRP) levels after surgery for colorectal cancer. High CRP can signal a serious complication called an anastomotic leak, where the surgical connection leaks. The goal was to see if a proactive mana…

This study compared two advanced embryo culture systems used in IVF with ICSI. One system has a built-in camera to watch embryos continuously, while the other uses periodic microscope checks. Researchers wanted to see if either system leads to more embryos implanting successfully…

This study explored whether the amount of omega-3 fatty acids in premature babies' bodies is linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured omega-3 levels in 62 premature newborns born before 29 weeks. The goal was to see if lower …

This completed study from France involved 530 families of children with rare developmental disorders. Researchers used surveys and interviews to understand how families feel about high-throughput genetic sequencing, including unexpected findings. The goal is to improve how doctor…

This study looked at whether measuring a pancreatic enzyme called lipase in surgical drains can help doctors detect pancreatic fistula earlier and more accurately than the current standard test (amylase). Researchers collected drain fluid and blood samples from 770 adults who had…

This study looked at 165 patients in the intensive care unit after major abdominal or urinary surgery. Doctors used lung ultrasound to measure fluid in the lungs and see if it could predict who would develop severe breathing problems. The goal was to find a simple bedside test to…

This study looked at how people with long-term mental disorders and their caregivers can work together to improve heart health. People with these conditions often die 20 years earlier than others, mainly from heart disease. The researchers interviewed 127 participants to understa…

This study looked at 40 adults with lumbar spinal stenosis (a narrowing in the spine that causes pain and trouble walking) who were scheduled for surgery. Researchers measured how fast they could walk before and after the operation using a 6-minute walk test. The goal was to see …

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This completed study looked at the buildup of germs (biofilm) on breathing tubes in 61 ICU patients who were on ventilators for more than 2 days. The goal was to better understand how this biofilm might be linked to ventilator-associated pneumonia. Researchers analyzed the struct…

This study looked at 39 hospitalized COVID-19 patients to see if a strong T-cell immune response is linked to worse symptoms. Researchers measured specific immune cells and chemicals in the blood. The goal was to understand why some patients get much sicker, not to test a treatme…

This study explored whether personality type (A or B) and stress levels differ between people with type 2 diabetes who have foot wounds and those who do not. Researchers used questionnaires to measure personality, stress, depression, and quality of life in 66 participants. The go…

This study involved 101 ICU patients to see if stopping their tube feeding before removing the breathing tube affects stomach fullness. Doctors used ultrasound to measure stomach content. The goal was to find ways to reduce the risk of food or liquid entering the lungs during tub…

This study explores whether a fast type of genome sequencing can help diagnose genetic conditions in fetuses with ultrasound abnormalities. Researchers will take samples from 149 pregnant women and their partners to analyze fetal DNA. The goal is to see if this approach can provi…

This study looked at how often low blood sugar (hypoglycemia) occurs in elderly diabetic patients living in nursing homes. Researchers used a continuous glucose monitor worn on the skin for 14 days to track blood sugar levels. The goal was to better understand the frequency and c…

This study tested whether simulation (a kind of role-play) can help adults with insulin-dependent diabetes learn to use the Freestyle Libre glucose monitor. Twenty-seven patients who had already completed a standard education program took part. The goal was to see if simulation i…

This study looked at 67 women who experienced domestic violence and sought help either at a specialized center (Maison des Femmes) or a conventional shelter. Researchers measured how many had post-traumatic stress disorder (PTSD) at their first visit and again six months later. T…

This completed study looked at 543 people who survived severe COVID-19 with lung failure (ARDS) to see if their socioeconomic status affected their recovery. Researchers checked breathing, mental health, and quality of life six months after leaving the ICU. The goal is to use thi…

This study tested a short, fast step-climbing exercise in 44 people with coronary artery disease to see if it is safe and useful for measuring anaerobic fitness. Participants stepped up and down a 17.5 cm step for one minute while heart rate and pain were monitored. The goal is t…

This completed French study followed 748 adults undergoing retina/vitreous surgery to see if taking blood thinners (anticoagulants or antiplatelets) raises the risk of bleeding complications. Researchers compared patients who continued or stopped their medication with those not o…

This pilot study tested whether giving water through a feeding tube works as well as IV saline for fluid expansion in 50 ICU patients on ventilators with low blood pressure. Researchers measured changes in heart function and blood flow. The goal was to gather initial data to desi…

This study looked at how fat (lipid) metabolism is linked to severe pneumonia caused by COVID-19 versus other germs. Researchers measured cholesterol and other fat-related substances in 62 adults with severe pneumonia. The goal was to understand these differences, not to test a t…

This study checked whether the energy-producing parts (mitochondria) of certain immune cells work differently in ICU patients with severe infections (sepsis) compared to those without infection. Researchers used leftover blood from routine tests to measure these changes in 36 pat…

This study looked at whether nutritional status affects the risk of death in people aged 70 and older with COVID-19. Researchers followed 426 hospitalized patients, comparing those with and without the virus. The goal was to understand if poor nutrition makes COVID-19 more danger…

This study tested whether monitoring the pupil's reaction to light (pupillometry) can help doctors give less opioid pain medicine during heart surgery. Fifty adults having coronary artery bypass surgery took part. The goal was to see if using pupillometry to guide pain medicine d…

This study looked at 278 adults on a heart-lung support machine (VA ECMO) to find early warning signs of dangerous bleeding. Researchers collected data on patient health history, treatments, and lab results at the start of support. The goal was to identify factors that increase b…

This study looked at whether GLP-1 agonists, a class of diabetes drugs, can reduce fat buildup in the heart muscle of people with type 2 diabetes. Researchers used MRI scans to measure heart fat before and after 6 months of treatment in 42 adults over 50. The goal was to understa…

This study looked at 34 older adults (ages 60-90) who had recently fallen to see if ankle muscle strength is linked to balance. Researchers measured the strength of muscles that move the ankle up and down and compared it to how much people sway while standing. The goal was to fin…

This study looked at 103 diabetic adults starting chemotherapy for cancer. Researchers used a continuous glucose monitor (Freestyle Libre) to track blood sugar changes. The goal was to see how often blood sugar went too low or too high during treatment, since chemotherapy and rel…

This study collected information from multiple hospitals on the Cor-Knot® device, which automatically ties knots during heart valve surgery. The goal was to see how safe and effective it is. Over 550 adults having planned valve surgery took part. The main focus was on whether lea…

This study tested whether a fast type of genetic test called rapid genome sequencing can find the cause of birth defects seen on ultrasound more quickly than current methods. Researchers included 184 pregnancies with certain ultrasound findings. The goal was to see if results cou…

This study looked at whether COVID-19 lockdowns caused delays in treating diabetic foot ulcers, leading to more amputations. Researchers analyzed hospital records from millions of diabetic patients in France between 2017 and 2020. They compared amputation rates during and after l…

This study surveyed over 4,500 hospital professionals in France to understand the psychological and ethical challenges they faced during the COVID-19 pandemic. Researchers asked about stress factors, traumatic impacts, and coping strategies. The goal was to learn how to better su…

This study looked at how caregivers' beliefs and attitudes might help or get in the way of teaching patients with schizophrenia to manage their own health. Researchers interviewed 21 medical and paramedical staff in France, both those who had given such education and those who ha…

This study looked at whether measuring muscle thickness with ultrasound before heart or lung surgery can help predict complications like kidney failure, breathing problems, or infections. Researchers enrolled 301 patients aged 65 and older at a French hospital. The day before sur…

This study examined 185 intensive care patients to understand how common venous congestion (a backup of blood in the veins) is and whether it contributes to organ problems like kidney or liver failure. Researchers used blood tests and ultrasound to check for signs of congestion. …

This completed study looked at fluid samples from the eyes of 137 people undergoing surgery for retinal detachment or other eye conditions. Researchers measured fats and proteins in these fluids to understand inflammation and cell death that can harm vision after surgery. The goa…

This study examined whether having a dedicated center for veno-venous ECMO (a machine that helps the lungs) reduces death rates. Researchers reviewed records of 172 adult patients treated in Dijon, France, over 10 years. The goal was to see if a structured care system lowers mort…

This study explores how virtual reality (VR) can be used to evaluate and improve walking in people with lower limb amputations. Researchers will test VR tolerance in 25 healthy volunteers and 25 amputees by having them walk on flat ground and slopes in a virtual environment. The …

This study looked at the fluid between cells (interstitial fluid) in 26 intensive care patients with septic or non-septic shock. Researchers aimed to understand how this fluid changes during severe infections, which could help explain why swelling occurs and how to better manage …

This study examined how immune cells change in people with coronary atherosclerosis (hardening of the arteries). Researchers compared blood and heart tissue samples from 61 patients undergoing heart surgery—some with coronary artery disease and some without. The goal was to see i…

This study looked at whether near-infrared spectroscopy (NIRS), a non-invasive light-based monitor, can detect changes in a common heart condition in very premature babies. Researchers measured oxygen levels in the brain and kidneys of 26 babies born before 32 weeks and compared …