STAGE IVB PROSTATE CANCER AJCC V8
Clinical trials for STAGE IVB PROSTATE CANCER AJCC V8 explained in plain language.
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Fighting fire with fire: High-Testosterone therapy aims to shock resistant prostate cancer
Disease control Recruiting nowThis study is testing if giving very high doses of testosterone, along with chemotherapy or a targeted radiation drug, can help control advanced prostate cancer that has spread and stopped responding to standard hormone-lowering treatments. The idea is to shock cancer cells that …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Could a break from cancer treatment be just as effective?
Disease control Recruiting nowThis study is testing if taking a planned break from a targeted radiation treatment is as effective as continuing it without a pause for men with advanced prostate cancer that has spread. The goal is to see if a shorter treatment course can control the cancer just as well while p…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Scientists test re-engineered immune cells to fight spreading prostate cancer
Disease control Recruiting nowThis early-stage study is testing the safety and best dose of a personalized immune therapy for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. Doctors take a patient's own immune cells, modify them in a lab to better targe…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New hope for Tough-to-Treat prostate cancer: Two-Drug combo enters major trial
Disease control Recruiting nowThis study is for men with advanced prostate cancer that has spread and no longer responds to standard hormone-lowering treatments. It will test if adding a chemotherapy drug called carboplatin to the standard chemotherapy drug cabazitaxel works better than cabazitaxel alone. The…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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New hope for Tough-to-Treat prostate cancer
Disease control Recruiting nowThis study is testing if adding a drug called vorinostat makes a newer radioactive cancer treatment work better for men with advanced prostate cancer. The cancer has spread and stopped responding to standard hormone treatments. Researchers want to see if vorinostat can 'turn on' …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Radioactive 'Trojan Horse' targets advanced prostate cancer in new trial
Disease control Recruiting nowThis study is testing a new treatment for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. The treatment uses a radioactive drug that seeks out and attaches to prostate cancer cells to deliver radiation directly to tumor…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Major trial aims to extend lives for men with spreading prostate cancer
Disease control Recruiting nowThis large study is testing if adding a chemotherapy drug (docetaxel) to the current standard two-drug hormone therapy helps men with prostate cancer that has spread live longer. It will enroll about 1,260 men to compare the three-drug combination against the standard two-drug tr…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Second shot at life: repeating a Cancer-Killing radiation treatment
Disease control Recruiting nowThis study is testing whether giving a second course of a targeted radiation drug can help men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The treatment, called 177Lu-PSMA-617, is given by IV and seeks out and delivers radiati…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Mayo clinic tests if less treatment works just as well for prostate cancer
Disease control Recruiting nowThis study is testing whether less aggressive treatment works as well as more intensive therapy for prostate cancer that has returned or spread. Researchers are comparing different approaches, including targeted radiation alone versus radiation combined with hormone-blocking drug…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New hope for tough prostate cancer: Two-Drug attack begins human testing
Disease control Recruiting nowThis early-stage study is testing whether adding the drug ruxolitinib to the standard treatment enzalutamide is safe and effective for men with advanced prostate cancer that has stopped responding to hormone-blocking therapy. The goal is to find the best dose and see if this comb…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: University of Michigan Rogel Cancer Center • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Double attack on advanced prostate cancer: radiation meets immune vaccine
Disease control Recruiting nowThis early-stage study is testing if combining two different treatments is safe and works better than one alone for advanced prostate cancer. One treatment is a targeted radiation drug that seeks out and kills cancer cells. The other is a personalized vaccine designed to train th…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Major trial questions if removing prostate helps men live longer with spreading cancer
Disease control Recruiting nowThis large study is testing whether adding surgery to remove the prostate or radiation therapy to standard drug treatments helps men with prostate cancer that has spread to other parts of the body live longer. It will enroll over 1,200 men who have already started standard hormon…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New Triple-Threat attack on advanced prostate cancer
Disease control Recruiting nowThis study is testing whether combining a bone-targeting radiation drug with one or two other medications works better for advanced prostate cancer that has spread to bones and stopped responding to standard hormone therapy. It will compare three approaches: the radiation drug al…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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DNA clues could predict which prostate cancer patients benefit from Bone-Targeting drug
Disease control Recruiting nowThis study aims to understand why some men with advanced prostate cancer that has spread to bones respond better to the drug radium-223 than others. Researchers will test blood samples from 48 patients to look for specific DNA repair defects that might make the cancer more sensit…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Sponsor: University of Washington • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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New hope for rare cancers: Triple-Threat therapy trial opens
Disease control Recruiting nowThis study is testing a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—for patients with rare types of bladder, kidney, penile, and other urinary tract cancers that have spread. The goal is to see if this three-drug approach can shrink tumors and control the d…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 24, 2026 12:01 UTC
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New immune cell therapy targets advanced prostate cancer that has stopped responding to standard treatments
Disease control Recruiting nowThis trial tests whether a new type of cell therapy (STEAP1 CART) combined with the hormone drug enzalutamide can help control advanced prostate cancer that has spread and stopped responding to standard treatments. The study will enroll 48 men whose cancer has progressed despite …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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Major trial aims to outsmart prostate Cancer's return
Disease control Recruiting nowThis large study is testing if using a PET scan to guide treatment decisions helps control prostate cancer that returns after surgery. For about 800 men, the scan will determine if they receive standard radiation and hormone therapy alone, or if stronger drug therapy and targeted…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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New combo therapy trial aims to stop prostate Cancer's spread
Disease control Recruiting nowThis study is for men whose prostate cancer has spread to a limited number of other body sites but still responds to hormone therapy. It compares standard radiation treatment alone to radiation combined with a daily pill (relugolix) that lowers testosterone. The goal is to see if…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Mar 19, 2026 14:55 UTC
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New Scan-Guided radiation attack on spreading prostate cancer
Disease control Recruiting nowThis study is testing whether adding targeted radiation to standard drug treatments helps men with advanced prostate cancer that has spread. Doctors use a special PET scan to find active cancer spots, then aim radiation directly at those areas. The goal is to see if this combined…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Northwestern University • Aim: Disease control
Last updated Mar 17, 2026 13:10 UTC
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Paradoxical approach: giving testosterone to fight prostate cancer
Disease control Recruiting nowThis early-stage study is testing a counterintuitive approach for men with advanced prostate cancer that has stopped responding to standard hormone-blocking treatments. Researchers are giving patients cycles of testosterone injections to see if rapidly switching between very low …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Mar 16, 2026 15:27 UTC
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Scientists test Two-Drug punch for tough prostate cancer
Disease control Recruiting nowThis study is testing a two-step treatment for advanced prostate cancer that has spread and stopped responding to standard hormone therapies and chemotherapy. First, patients take a pill (abemaciclib) for two weeks, aiming to make cancer cells more visible. Then, they receive a t…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Vadim S Koshkin • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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New combo attack on advanced prostate cancer
Disease control Recruiting nowThis study is testing whether adding a new targeted drug called talazoparib to standard hormone-blocking treatments can better control advanced prostate cancer that has spread. It aims to see if this combination helps stop cancer growth for longer by preventing cancer cells from …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 10, 2026 12:52 UTC
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Genetic testing trial aims to match men with best prostate cancer drug
Disease control Recruiting nowThis study is testing whether using genetic testing to guide treatment choices works better for men with advanced prostate cancer that has stopped responding to standard hormone therapy. About 474 participants will have their tumor tissue analyzed, and then be assigned to one of …
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Mar 02, 2026 15:29 UTC
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Freezing cancer to stop the pain: new combo therapy trial
Symptom relief Recruiting nowThis study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Mar 31, 2026 12:11 UTC
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Scientists probe prostate Cancer's defenses against radiation
Knowledge-focused Recruiting nowThis study aims to learn why some advanced prostate cancers become resistant to a targeted radiation treatment called 177Lu-PSMA therapy. Researchers will take small tissue samples (biopsies) from 30 patients before and during their treatment to analyze the cancer cells. The goal…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Can simpler language bridge the health gap for cancer survivors?
Knowledge-focused Recruiting nowThis study is testing whether a simpler, easier-to-read survivorship care plan helps Black and African American men who have finished treatment for prostate cancer. Researchers want to see if this tailored plan helps patients understand their follow-up care and manage long-term s…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: Emory University • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:11 UTC
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Scientists build a living library of cancer to unlock treatment secrets
Knowledge-focused Recruiting nowThis study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…
Matched conditions: STAGE IVB PROSTATE CANCER AJCC V8
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Mar 17, 2026 13:09 UTC