PARKINSON DISEASE (DISORDER)

This study is testing whether a supplement made from a compound found in broccoli (glucoraphanin) can help control the progression of neurodegenerative diseases. It will enroll 300 adults with Parkinson's or Multiple Sclerosis, and children with neuromuscular diseases, to see if …

This is a first-in-human study to check the safety and how the body processes a new single-injection drug called SER-252. It is for people with Parkinson's disease who experience daily 'off' periods where their medication wears off and symptoms return. The study will give increas…

This study is testing whether daily brain stimulation using a non-invasive magnetic device can help control Parkinson's disease symptoms. Over 12 months, 90 participants will use the device for 30 minutes daily to see if it improves movement, reduces tremor, and potentially decre…

This study is testing if a new type of physical therapy using robotic arms and video game-like exercises can help improve both thinking skills and arm movement in adults with Parkinson's disease, multiple sclerosis, or who have had a stroke. Researchers will compare this high-tec…

This study is testing whether doctors can detect early signs of Parkinson's disease or REM sleep behavior disorder by analyzing tiny tissue samples taken during routine colonoscopies. Researchers want to see if they can find a specific protein that builds up in people with these …

This study is testing whether doctors can detect Parkinson's disease earlier by looking for a specific protein in colon tissue samples taken during routine colonoscopies. Researchers are enrolling 20 adults with Parkinson's who are already scheduled for colon cancer screening. Th…

This study is exploring whether a type of light therapy, called whole-body photobiomodulation, can help improve movement and thinking problems in people with Parkinson's disease. It will involve 15 participants who will receive light therapy sessions three times a week for about …

This study is testing whether a high-intensity exercise program can be safely done at home by people with Parkinson's disease, and whether a special headband can effectively track their sleep. Researchers want to see if these home-based tools are easy to use and acceptable to par…

This study aims to see if adding specific exercises to standard physical therapy helps people with Parkinson's disease who also have significant muscle loss (sarcopenia). Researchers will compare standard rehab alone to rehab plus either resistance band training or treadmill walk…

This study is testing whether a daily probiotic supplement can help reduce depression in people who have Parkinson's disease. About 60 participants with mild to moderate Parkinson's and depression will take either the probiotic or a placebo pill for 12 weeks. Researchers will mea…

This study is testing whether a mental training technique called 'motor imagery' can help people with Parkinson's disease. Researchers want to see if imagining movements in your mind can reduce fear of falling and improve walking and balance. They are recruiting 50 adults with Pa…

This study is testing a safe, non-invasive brain stimulation device that people with Parkinson's disease can use at home. Over 30 adults will wear the headset for 13 minutes a day, five days a week, for three weeks to see if it helps reduce movement problems like tremor, stiffnes…

This study is testing whether a 6-week group program can help people with Parkinson's disease better manage their fatigue. About 80 participants will either attend the group sessions, led by an occupational therapist, or receive standard educational fact sheets. The main goal is …

This study aims to find out if a new oral medication called IRL757 is safe and tolerable for people with Parkinson's disease who also experience apathy—a lack of interest or motivation. About 75 participants will take either the study drug or a placebo (inactive pill) daily for 1…

This study is testing if a technique called mental imagery can provide immediate help for hand and arm skills in people with Parkinson's disease. Researchers will have 30 participants with Parkinson's imagine performing specific hand tasks and then measure their actual physical p…

This study aims to translate and validate an English questionnaire about gastrointestinal symptoms into Italian for Parkinson's disease patients. Researchers will work with 190 Italian-speaking Parkinson's patients to create a reliable Italian version of the symptom assessment to…

This study aims to find new, less invasive ways to detect and monitor Parkinson's and Alzheimer's disease earlier. Researchers will collect and analyze blood samples, genetic data, and brain scans from 500 people with these conditions, some of whom also have type 2 diabetes. The …

This study aims to understand why Parkinson's disease affects leg muscle control and walking. Researchers will test if a brief, non-invasive stimulation of a nerve in the neck can improve muscle activity and balance in 75 participants. The goal is to gather evidence for future la…

This study aims to understand how brain signals change in Parkinson's disease patients when they take their medication. Researchers will measure brain activity in 30 patients who have deep brain stimulation devices, tracking both movement symptoms and mood changes. The goal is to…

This study aims to discover markers in the blood that can predict how well a person with Parkinson's disease will respond to deep brain stimulation (DBS) surgery. Researchers will collect blood samples and leftover surgical tissue from 30 patients undergoing DBS to look for prote…

This research study aims to understand how a specific brain area helps people with Parkinson's disease transfer walking skills learned on a special treadmill to regular ground walking. Researchers will use non-invasive brain stimulation on 24 participants to see if boosting brain…