PARKINSON DISEASE (DISORDER)

This study tests a new, faster method to deliver the drug AB-1005 into the brain of people with advanced Parkinson's disease. The goal is to see if the new approach can consistently reach the target area while being safer and quicker. 18 participants will be enrolled to assess th…

This study compares two types of cognitive-based balance training for people with Parkinson's disease: one using virtual reality (VR) and the other combining balance exercises with mental tasks like counting. Thirty-four participants aged 40-80 will do 16 sessions over 8 weeks. R…

This study tests a home-based dual-task training program for people with Parkinson's disease who have mild cognitive impairment and are at high risk for dementia. Participants will cycle on a stationary bike while playing brain-training games on a tablet, three times a week for 3…

This study will test whether a gentle, non-invasive brain stimulation technique called tDCS can improve verbal fluency, thinking, and motor control in people with Parkinson's disease. Twenty participants aged 50-90 with Parkinson's and a verbal fluency deficit will receive the st…

This study will test whether a special exercise program called LSVT BIG, done via video calls at home, works as well as the same program done in a clinic. Forty people with mild-to-moderate Parkinson's disease will be randomly assigned to either remote or in-person therapy for 4 …

This study tests a robotic device designed to help people with stroke, Parkinson's disease, ALS, or mild cognitive impairment improve their arm and hand function. Thirty adults will receive standard rehabilitation, and half will also use the robot for up to 30 minutes per session…

This study tests a smartphone app called CuePD that uses a person's favorite music to help retrain their walking. The goal is to improve gait and reduce fall risk in people with Parkinson's disease. Forty participants who can walk without help will use the app at home and while o…

This study tests a 6-week exercise program called SwallowFit designed to improve swallowing fitness in people with Parkinson's disease. Researchers will compare the exercise group to those receiving standard care. The goal is to see if the exercises lead to safer swallowing and b…

This study tests a new, non-invasive brain stimulation technique called temporal interference stimulation (TIS) for people with Parkinson's disease. The device uses electrodes on the scalp to send electrical currents deep into the brain, aiming to improve movement problems withou…

This study tests whether adding whole-body vibration (standing on a vibrating platform) to a home exercise program helps people with Parkinson's disease improve balance, mobility, and fall risk more than exercise alone. About 68 adults aged 50-75 with mild to moderate Parkinson's…

This study tests whether repeated sessions of a gentle brain stimulation technique called tDCS can improve motor function in people with Parkinson's disease. Thirty adults with moderate-stage Parkinson's will receive stimulation over several days. The goal is to see if this safe,…

This study tests whether a mild electrical stimulation applied to the ear (taVNS) can improve walking, balance, and movement in people with Parkinson's disease when combined with physical therapy. Thirty participants will receive either real or sham stimulation during therapy ses…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve walking in people with Parkinson's disease. 81 participants with mild to moderate Parkinson's who have trouble starting to walk will receive …

This study looks at brain activity recorded from deep brain stimulation (DBS) devices in 20 people with Parkinson's disease. Researchers want to see if certain brain signals are linked to symptoms like sudden anxiety, impulse control problems, and hallucinations. Participants wil…

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This study looks at how the nerves connecting the gut and brain affect Parkinson's disease. Researchers will compare people with Parkinson's, those at risk, and healthy volunteers. Participants will give blood, stool, and saliva samples, have X-rays and colon exams, and answer qu…

This observational study will examine whether prior expectations increase false perceptions in Parkinson's patients who experience visual hallucinations. About 60 participants, including patients with and without hallucinations and healthy volunteers, will complete a computer-bas…

This study will test whether artificial intelligence (AI) can predict how Parkinson's disease will progress and how patients will respond to medication. One hundred people with Parkinson's will wear a smartwatch and use a mobile app for one year. The AI models will analyze data f…