PARKINSON DISEASE (DISORDER)

This study tests whether a home-based program combining cycling with cognitive games on a tablet can prevent worsening of daily activities in people with Parkinson's disease who have mild cognitive impairment and are at high risk for dementia. 42 participants will be randomly ass…

This study tests a new method to deliver the drug AB-1005 into a specific part of the brain for people with advanced Parkinson's disease. The goal is to make the procedure faster and easier while still getting the right amount of drug to the right place. About 12 participants age…

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can improve walking, especially starting to walk, in people with Parkinson's disease. Researchers will compare high-frequency and low-frequency stimulation to a sham (fake) treatment in 81 pa…

This study tests a new, non-invasive brain stimulation method called temporal interference stimulation (TIS) for people with mild to moderate Parkinson's disease. The goal is to see if TIS can improve movement and other symptoms without the need for surgery. Researchers will use …

This study tests whether a non-invasive brain stimulation technique called tDCS can improve motor function in people with Parkinson's disease. Thirty adults with moderate-stage Parkinson's will receive repeated sessions over a week. The goal is to see if this safe, portable treat…

This study tests whether a mild electrical stimulation on the ear (taVNS) can improve walking and balance in people with Parkinson's disease. About 30 adults with Parkinson's will receive either real taVNS or a fake version during physical therapy sessions. Researchers will measu…

This study tests whether an accelerated course of repetitive transcranial magnetic stimulation (rTMS) can improve both movement and thinking problems in people with mild to moderate Parkinson's disease. Forty participants aged 50 to 90 will receive six sessions of magnetic pulses…

This study tests a new approach to help people with early Parkinson's disease who have mild thinking or memory problems. Instead of doing computer brain games, participants work with an occupational therapist to learn practical strategies for everyday challenges, like remembering…

This study tests a smartphone app called CuePD that uses a person's favorite music to help retrain walking in people with Parkinson's disease. Over 12 weeks, 40 participants will use the app at home and while out walking to see if it improves gait and reduces fall risk. The goal …

This study looks at whether adding whole-body vibration (standing on a vibrating platform) to a standard home exercise program can improve balance, mobility, and reduce fall risk in people with Parkinson's disease. 68 adults aged 50-75 with mild to moderate Parkinson's will be ra…

This study tests a non-invasive brain stimulation technique called tDCS in 20 people with Parkinson's disease who have trouble with verbal fluency (finding words). The goal is to see if it can improve thinking, memory, and movement. Participants will receive either real or fake s…

This study tests whether a 6-week exercise program called SwallowFit can improve swallowing ability in people with Parkinson's disease. Researchers will compare the exercise group to those receiving standard care. The goal is to see if the program helps maintain or improve swallo…

This study tests two artificial intelligence (AI) models that aim to predict how Parkinson's disease will progress and whether medication side effects will occur. Researchers will collect data from 100 people with Parkinson's using a smartwatch and a mobile app, along with their …

This study aims to understand how the nerves connecting the gut and brain affect Parkinson's disease. Researchers will compare people with Parkinson's, those at risk, and healthy volunteers. Participants will provide blood, stool, and saliva samples, plus undergo X-rays and colon…

This observational study aims to understand why some people with Parkinson's disease experience visual hallucinations. Researchers will compare how prior expectations influence false perceptions in patients with and without hallucinations, as well as healthy volunteers. Participa…