PARKINSON DISEASE (DISORDER)

This study is testing a home-based training program designed to help people with Parkinson's disease who are at high risk for dementia. Participants will pedal a stationary bike while playing brain-training games on a tablet, aiming to improve both thinking skills and the ability…

This study aims to see if a 12-week supervised aerobic exercise program can improve brain blood flow, thinking skills, walking, and overall well-being in people with mild to moderate Parkinson's disease. Forty participants will be randomly assigned to either follow the exercise p…

This study is testing a new surgical technique to deliver an experimental gene therapy called AB-1005 directly into the brain of people with Parkinson's disease. The goal is to make the delivery procedure faster and more consistent, while still getting the treatment to the right …

This study is testing if a therapy called Lecigon, delivered directly to the intestines, is better than standard oral medications at managing the neuropsychiatric side effects that can occur with Parkinson's disease treatment. It will involve 150 adults with Parkinson's who exper…

This study aims to see if adding whole-body vibration exercise to a home workout helps people with Parkinson's disease improve their balance, mobility, and reduce their risk of falling more than just doing home exercises. Researchers will compare two groups of 68 participants ove…

This study is testing whether repeatedly applying gentle, non-invasive electrical stimulation to both sides of the brain can improve movement problems in people with Parkinson's disease. It will involve 30 participants with moderate Parkinson's to see if the treatment's benefits …

This study is testing a new wearable device called EarStim that delivers gentle electrical stimulation to the ear. It aims to see if this can safely provide temporary relief from movement symptoms like stiffness and slowness in people with moderate to severe Parkinson's disease. …

This study is testing whether a gentle, non-invasive electrical stimulation applied to the ear (called taVNS) can improve movement problems when added to standard physical therapy for Parkinson's disease. Researchers will compare the real stimulation to a fake (sham) version in 3…

This study is testing a new program that teaches practical thinking strategies to help people with early Parkinson's disease manage daily memory and thinking problems. 114 participants will work with a therapist to learn personalized techniques, like using checklists or planning …

This study tests whether a specialized swallowing exercise program called SwallowFit can improve swallowing function in people with Parkinson's disease. The trial will enroll 80 US service members, veterans, and family members with Parkinson's who have swallowing concerns. Partic…

This study is testing whether a non-invasive brain stimulation technique can improve walking problems in people with Parkinson's disease. Researchers will use a magnetic coil placed on the scalp to stimulate a specific brain area involved in movement planning. They will compare d…

This study aims to test whether artificial intelligence (AI) models can predict how Parkinson's disease will progress and how patients might respond to medications. It will enroll 100 people with Parkinson's who will use a smartwatch and mobile app to collect daily health data. T…

This study aims to understand why some people with Parkinson's disease experience visual hallucinations. Researchers will have 60 participants, including Parkinson's patients with and without hallucinations, complete computer-based visual tasks and thinking tests. The goal is to …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients. Temporal interference stimulation (TIS) is a novel non-invasive techni…