PARKINSON DISEASE (DISORDER)

This study is testing a natural compound from broccoli (sulforaphane) in 300 people with Parkinson's disease, relapsing-remitting multiple sclerosis, or certain childhood nerve and muscle diseases. The goal is to see if it can protect the brain, reduce symptoms, and improve quali…

This study tests a treatment called Lecigon, given directly into the intestine, for people with Parkinson's disease who have mental and behavioral side effects from standard medications. The goal is to see if this approach reduces symptoms like mood swings, compulsions, and confu…

This study looks at whether tissue samples taken from the colon during a routine colonoscopy can find signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). Researchers will check for a protein called alpha-synuclein, which is linked to Parkinson's. The goal is to cat…

This study looks at whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers want to see if a protein called alpha-synuclein is present in the colon of people with Parkinson's. The goal is to catch the disease earlier, before mo…

This study tests a home-based fall prevention program for people with Parkinson's disease. About 50 participants will have their homes assessed by occupational therapists to find fall risks and get recommendations for equipment and changes. The goal is to help people feel safer a…

This study tests an experimental drug called IRL757 in people with Parkinson's disease who also experience apathy (loss of interest or motivation). The main goal is to see if the drug is safe and tolerable over 12 weeks. About 75 participants will receive either IRL757 or a place…

This study tests whether a gentle, non-invasive nerve stimulation called taVNS can improve how the body controls heart rate and blood pressure in people with Parkinson's disease. About 24 participants will receive the stimulation while performing simple physical tasks. The goal i…

This study tests whether a 12-week supervised aerobic exercise program can improve brain blood flow, thinking skills, and walking in people with Parkinson's disease. Researchers will compare 40 participants who either exercise or continue their usual care. The goal is to see if e…

This study tests whether a daily probiotic can reduce depression symptoms in people with Parkinson's disease. 60 participants will take either a multi-strain probiotic or a placebo for 12 weeks. Researchers will measure mood changes using standard depression questionnaires. The g…

This study tests a device called EarStim that gently stimulates the ear to temporarily improve movement problems in people with Parkinson's disease. It is for adults who have moderate to severe Parkinson's and experience 'off' periods when their usual medication wears off. The st…

This study looks at whether using walking poles during an 8-week walking program can improve walking, movement, and thinking in people with Parkinson's disease. About 40 participants will either walk with poles or without, and their progress will be tracked before, after, and 3 m…

This study tests a non-invasive brain stimulation device (Sphere V3.0) to help improve movement problems like tremor and stiffness in people with Parkinson's disease. Thirty adults aged 18-80 with stable medication will use the device at home for 13 minutes each weekday for 3 wee…

This study aims to make a high-intensity exercise program safe and easy to do at home for people with Parkinson's disease. It also tests a headband that tracks sleep. Sixteen participants in Colorado will try the program and give feedback. The goal is to improve access to exercis…

This early-stage study tests a single dose of SER-252 in 40 people with Parkinson's disease who experience motor fluctuations (uncontrolled movements). The main goal is to check the drug's safety and how the body processes it. Participants receive either SER-252 or a placebo, and…

This study tests whether a 6-week group program led by an occupational therapist can help people with Parkinson's disease feel more confident in managing their fatigue. 80 participants will be randomly assigned to either the program or standard information sheets. The goal is to …

This study tests whether motor imagery training—mentally practicing movements without actually moving—can reduce kinesiophobia (fear of movement) and improve walking and balance in people with Parkinson's disease. Fifty participants aged 40-75 will be enrolled. The goal is to see…

This study tests whether a non-invasive brain stimulation device, used at home under remote supervision, can improve motor symptoms like slowness, stiffness, and walking difficulty in people with Parkinson's disease. 68 participants with mild-to-moderate Parkinson's will receive …

This study tests whether shining special light on the whole body (photobiomodulation) can help with movement and thinking problems in people with Parkinson's disease. About 15 adults with mild to moderate Parkinson's will receive light sessions three times a week for 10 weeks. Re…

This study tests whether a daily 30-minute treatment using gentle magnetic pulses (T-PEMF) can improve movement and reduce medication needs in people with Parkinson's disease. Over 12 months, 90 participants will receive either real or sham treatment for the first 6 months, then …

This study looks at whether mental imagery—picturing a movement without actually doing it—can immediately improve hand and arm function in people with Parkinson's disease. Researchers will enroll 30 adults aged 40-75 with mild to moderate Parkinson's. Participants will be asked t…

This study is testing if a new type of physical therapy using robotic arms and video game-like exercises can help improve both thinking skills and arm movement in adults with Parkinson's disease, multiple sclerosis, or who have had a stroke. Researchers want to see if this high-t…

This study looks at how brain activity changes during motor and mood swings in Parkinson's disease. Researchers will record brain signals from 30 people with Parkinson's who have deep brain stimulation devices. The goal is to find patterns that could lead to smarter, adaptive tre…

This study is looking for 500 adults with Parkinson's disease, Alzheimer's disease, or type 2 diabetes to help researchers find new ways to detect and track these conditions earlier. Participants will provide blood samples, undergo brain scans, and complete thinking and movement …

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will check if the Italian version works well by testing it with 190 patients across multiple centers. The goal is to help doctors better …

This study looks at whether stimulating a specific brain area (the posterior parietal cortex) can help people with Parkinson's disease transfer walking skills learned on a treadmill to walking on the ground. 24 participants will receive either real or fake brain stimulation to co…

This study aims to find proteins and genetic material in the blood that can predict whether deep brain stimulation (DBS) surgery will help people with Parkinson's disease. Researchers will collect blood and leftover brain tissue from 30 participants undergoing DBS and track their…

This study looks at why people with Parkinson's disease have trouble activating their leg muscles. Researchers will test if stimulating a nerve in the neck (vagus nerve) can improve muscle activation, walking, and balance. The study involves 75 participants and aims to better und…