PARKINSON DISEASE (DISORDER)

This early-stage trial tests a new oral drug called MF1 in healthy adults and people with Parkinson's disease. The drug aims to block a harmful protein (alpha-synuclein) linked to Parkinson's. The main goal is to check safety and how the body processes the drug, not yet whether i…

This study compares Tai Chi and Qi-Gong, two gentle movement therapies, to see which better improves balance and motor function in people with stage I Parkinson's disease. Fifty participants aged 50 to 65 will receive either Tai Chi or Qi-Gong alongside standard physical therapy …

This study tests a treatment called Lecigon® for people with Parkinson's disease. It is a gel given through a tube into the intestine that delivers a steady dose of medication. The goal is to see if this method reduces certain behavioral and emotional side effects better than sta…

This study tests a home-based fall prevention program for people with Parkinson's disease. Participants receive a home assessment, personalized recommendations, and an action plan to improve safety and accessibility. The goal is to boost confidence, reduce falls, and help people …

This study is testing a supplement made from a broccoli compound (bioactivated GRA) in 300 people with Parkinson's disease, relapsing-remitting multiple sclerosis, or certain childhood nerve diseases. Participants will take the supplement daily for 6 months. Researchers will trac…

This study aims to find better ways to diagnose Parkinson's disease in its earliest stages. Researchers will use wearable devices to track movement and analyze blood samples for specific markers from nerve cells. By combining these digital and biological clues, they hope to creat…

This study looks at whether a protein linked to Parkinson's disease can be found in colon tissue samples taken during a routine colonoscopy. Researchers will compare samples from people with Parkinson's, those with REM sleep behavior disorder, and healthy individuals. The goal is…

This study tests whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers look for a protein called alpha-synuclein in the colon of people already diagnosed with Parkinson's. If successful, this could lead to earlier detection a…

This early study tests whether a gentle, non-invasive nerve stimulation device placed in the ear (taVNS) can improve how the body regulates heart rate and blood pressure in people with Parkinson's disease. Researchers will measure changes during simple physical tasks like deep br…

This pilot study tests whether an accelerated course of repetitive transcranial magnetic stimulation (rTMS) can improve movement and thinking in people with mild to moderate Parkinson's disease. Forty participants aged 50 to 90 will receive six sessions of high-frequency magnetic…

This early-stage study tests a single dose of SER-252 in 40 people with Parkinson's disease who experience motor fluctuations (times when symptoms worsen). The main goal is to check safety and how the drug moves through the body. Participants receive either the drug or a placebo,…

This study is testing whether a 12-week group exercise program, designed for each person's needs, is practical and helpful for people with Parkinson's disease. The program includes strength, aerobic, balance, and cognitive exercises, done both in person and at home. Researchers w…

This study tests a new approach to help people with early Parkinson's disease who have mild memory or thinking problems. Instead of brain games, participants learn practical strategies from an occupational therapist to handle everyday challenges like remembering tasks or staying …

This study tests two different home exercise programs designed to prevent falls in people with Parkinson's disease. Thirty participants will do one of the programs for six weeks, and researchers will measure changes in balance, walking, and fear of falling. The goal is to find ou…

This study is testing whether a high-intensity exercise program and a sleep-tracking headband can be used safely and effectively at home by people with Parkinson's disease. Sixteen participants in Colorado will try the remote program and give feedback. The goal is to make exercis…

This study tests whether a daily probiotic supplement can help treat depression in people with Parkinson's disease. Sixty adults with mild to moderate Parkinson's and depression will take either the probiotic or a placebo for 12 weeks. Researchers will measure changes in mood and…

This study tests whether using walking poles during an 8-week independent walking program can improve walking, movement, and thinking in people with Parkinson's disease. Forty participants will walk at least three times a week, either with or without poles. Researchers will measu…

This study tests whether daily 30-minute sessions of transcranial pulsed electromagnetic fields (T-PEMF) can improve movement and other symptoms in people with Parkinson's disease. 90 participants will receive either real or sham treatment for the first 6 months, then all receive…

This study tests a device called EarStim that gently stimulates the ear to temporarily improve movement problems in people with Parkinson's disease. About 90 adults with moderate to severe Parkinson's who experience 'off' episodes will try the device in a clinic and later at home…

This study tests whether a noninvasive brain stimulation device, used at home under remote supervision, can improve motor symptoms like stiffness, slowness, and walking difficulty in people with Parkinson's disease. 68 participants with mild-to-moderate Parkinson's will receive e…

This study looks at whether a 12-week supervised aerobic exercise program can improve brain blood flow, thinking skills, and walking in people with Parkinson's disease. Researchers will compare 40 participants who either do the exercise program or continue their usual care. The g…

This study tests an experimental drug called IRL757 in 75 people with Parkinson's disease who also have apathy (loss of interest or motivation). The main goal is to see if the drug is safe and tolerable over 12 weeks. Researchers will also check if it helps improve apathy symptom…

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck can improve leg muscle control, walking, and balance in people with Parkinson's disease. Researchers will compare real stimulation to a sham (fake) version in 75 participants. The goal i…

This study tests whether sensor-based robotic arm rehabilitation can improve both thinking skills (like memory and attention) and physical movement in adults with Parkinson's disease, multiple sclerosis, or stroke. Participants will receive 25 sessions of either robotic therapy w…

This study tests a non-invasive device called Sphere V3.0 that delivers gentle electrical pulses to the scalp to improve movement problems in Parkinson's disease. Thirty adults with Parkinson's will use the device at home for 13 minutes each weekday for 3 weeks, then be monitored…

This study explores whether mentally practicing a hand dexterity test can immediately improve actual performance in people with Parkinson's disease. Thirty participants will time themselves both physically and mentally performing the Nine-Hole Peg Test. The goal is to see if moto…

This study tests if whole-body light therapy (photobiomodulation) can safely improve movement and thinking in people with Parkinson's disease. Fifteen adults with mild to moderate Parkinson's will receive about 30 sessions over 10 weeks. Researchers will measure changes in motor …

This study tests whether a 6-week group program led by an occupational therapist can help people with Parkinson's disease feel more confident in managing their energy and fatigue. About 80 participants will be randomly assigned to either the group program or receive standard info…

This study tests whether motor imagery training—mentally practicing walking and balance tasks—can reduce kinesiophobia (fear of movement) and improve gait and balance in people with Parkinson's disease. Fifty participants will be recruited to perform mental imagery exercises alon…

This study follows 450 people with Parkinson's disease for four years to learn why some become less active and what helps them stay active. Participants wear activity monitors and complete tests and questionnaires. The goal is to identify early warning signs of declining activity…

This study is looking for new, less invasive ways to diagnose and track Parkinson's disease, Alzheimer's disease, and type 2 diabetes. Researchers will study 500 participants using blood tests, brain scans, and genetic analysis to find early signs of these conditions. The goal is…

This study is looking for clues in the blood that might tell doctors ahead of time whether deep brain stimulation (DBS) surgery will work well for a person with Parkinson's disease. Researchers will collect blood and leftover brain tissue from 30 people who are already scheduled …

This study looks at brain activity in 30 people with Parkinson's disease who have deep brain stimulation (DBS) implants. Researchers want to understand the brain signals behind motor and mood changes that happen when medication wears off. By recording brain waves and stimulation …

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will test the translated version with 190 Italian-speaking patients to make sure it works correctly. The goal is to give doctors a reliab…

This study looks at how a brain area called the Posterior Parietal Cortex helps people with Parkinson's disease transfer walking skills from a treadmill to the ground. Researchers will use mild brain stimulation (rTMS) in 24 participants to see if it improves stride length and ot…