OVARIAN CARCINOMA

This study tests whether using a special camera and fluorescent dye during surgery can help surgeons see blood flow in the bowel and reduce the risk of leaks after the operation. About 310 women with ovarian cancer who need bowel surgery will take part. The goal is to see if this…

This study tests whether taking the drug olaparib for one year works as well as taking it for two years to keep ovarian cancer from coming back. Participants have a specific genetic type of advanced ovarian cancer (BRCA mutation or HRD positive) and have already responded to init…

This early-phase study tests a new treatment called CIML NK cell therapy for people with recurrent ovarian cancer that no longer responds to platinum-based chemotherapy. The therapy uses specially trained natural killer cells from a donor to attack the cancer. The study aims to f…

This study tests whether the drug belzutifan can shrink or control certain gynecologic cancers (like ovarian, endometrial, cervical, vaginal, or vulvar) that have come back or not gone away. About 32 adults with clear cell carcinoma will receive belzutifan pills. The main goal is…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells. The vaccine is designed to train the immune system to recognize and attack ovarian cancer. The study involves 10 women with advanced ovarian cancer who will receive the vaccine alongside st…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The trial includes 740 participants with 13 different cancer types, such as lung, breast, and prostate cancer. The goal is to see if the …

This early-phase study tests an experimental pill, NKT3964, designed to break down a protein (CDK2) that helps cancer cells grow. About 150 adults with advanced or metastatic solid tumors (including ovarian, endometrial, breast, gastric, and lung cancers) that have stopped respon…

This study tests a technique called acute normovolemic hemodilution (ANH) during ovarian cancer surgery. Before surgery, some blood is removed and replaced with fluids, then returned later. The goal is to see if this reduces the need for donor blood transfusions. About 86 adults …

This early-phase study tests a new drug called AVA6000, a chemotherapy that is designed to activate only inside tumors, potentially reducing side effects. It is for people with advanced solid tumors (like breast, ovarian, or salivary gland cancer) that have not responded to stand…

This study tests a new drug called JAB-8263 in adults with advanced solid tumors (like lung or ovarian cancer) or blood cancers (like leukemia) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 15…

This early-phase study tests a new drug (DT2216) combined with standard chemotherapy (paclitaxel) in 30 people with ovarian cancer that has returned and is resistant to platinum-based treatments. The main goal is to find the safest dose of DT2216 when given with paclitaxel, and t…

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or are not responding to standard treatments. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest …

This study tests a new ultrasound method called ultrasound microvessel imaging (UMI) to see if it can better detect blood flow in ovarian growths. Current tools often miss early signs of cancer. About 40 women scheduled for surgery for ovarian lesions will get this extra scan. Do…

This early-phase study tests a radioactive tracer called [18F]FTT to see if it can help PET/CT scans find more tumor cells in people with solid tumors, including ovarian, breast, and fallopian tube cancers. About 300 participants will receive the tracer and undergo imaging. The g…

This study looks at two surgeries for women with BRCA1 gene changes who are at high risk for ovarian cancer. One surgery removes only the fallopian tubes, while the other removes both tubes and ovaries. The goal is to see if removing just the tubes works nearly as well at prevent…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests whether a 16-week home-based exercise program (aerobic and strength training) is practical and helpful for women with advanced ovarian or endometrial cancer who are starting chemotherapy after surgery. Researchers want to see if it improves leg function and reduc…

This study tests a tool called CASI that helps ovarian cancer patients, their caregivers, and doctors set a shared plan for each doctor visit. The goal is to make conversations more focused and helpful. About 112 people with advanced ovarian cancer and their caregivers will take …

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can improve quality of life, especially digestive issues like nausea and bloating, in people receiving their first chemotherapy for ovarian cancer. About 116 participants will either rec…

This study aims to understand why some people who have had ovarian or other solid cancers later develop blood cancers. Researchers will follow 2,000 participants to identify genetic and environmental risk factors. The goal is to improve monitoring and prevention for cancer surviv…

This study tests a workshop called HOPE-C, designed to reduce burnout among doctors, nurses, and social workers who care for ovarian cancer patients. The workshop helps clinicians share their challenging experiences and build peer support. Researchers will enroll 25 participants …

This study aims to understand how ovarian cancer affects the immune system, especially in the bone marrow and blood. Researchers will compare immune cells from 90 women with ovarian cancer to those without cancer. The goal is to find new ways to boost the immune system to fight t…

This study is gathering information and tumor samples from 2,000 people with low-grade ovarian or peritoneal tumors. The goal is to create a detailed database that helps researchers learn more about these rare cancers and how they are treated. This knowledge may lead to better tr…

This observational study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for possible futur…

This study tests whether a computer-generated character (called PERLA) can help cancer patients learn about genetic testing as well as a human counselor does. The goal is to make genetic testing easier to access for people who often miss out, like those in rural areas or who spea…

This study follows 600 Japanese women who carry BRCA1 or BRCA2 gene variants to see how often they develop ovarian, fallopian tube, or peritoneal cancers. Researchers will also look at risk factors and check tissue samples for hidden cancers. The goal is to better understand and …

This study looks at how the immune system reacts to breast and ovarian cancer. Researchers will collect tumor and blood samples from 160 women before surgery to study immune cells and find clues that might predict survival. No new treatment is given—the goal is to learn more abou…

This study is testing new blood tests that look for signs of many different cancers at the same time. Researchers want to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will be split into three groups:…