OVARIAN CARCINOMA

This early-phase trial tested a combination of two drugs, sapanisertib and ziv-aflibercept, in 83 adults with advanced solid tumors that had spread or could not be removed by surgery. The main goal was to find the safest dose and identify side effects. The approach aims to slow t…

This study tested a combination of two drugs, pamiparib and surufatinib, in 29 women with a tough-to-treat type of ovarian cancer that had stopped responding to platinum chemotherapy and a prior PARP inhibitor. The goal was to see if the combo could shrink tumors or slow cancer g…

This early-stage trial tested a personalized immunotherapy called TG4050 in 64 women with advanced ovarian, fallopian tube, or peritoneal cancer who had completed standard chemotherapy and were in remission. The treatment aims to train the immune system to recognize and attack ca…

This study tested a new drug (TJ004309) combined with an approved immunotherapy (atezolizumab) in 25 people with advanced ovarian, head and neck, lung, gastrointestinal, or triple-negative breast cancers. The goal was to see if the combination could shrink tumors. Participants ha…

This study tested whether adding an experimental drug (MK-4830) to standard chemotherapy and immunotherapy (pembrolizumab) could better reduce tumor DNA in the blood of people with advanced ovarian cancer. 160 participants with stage III or IV high-grade serous ovarian cancer wer…

This early-phase trial tested a combination of two drugs—trabectedin and durvalumab—in 40 people with advanced soft-tissue sarcoma or ovarian cancer that had not responded to prior treatments. The main goal was to find the safest dose and check for early signs of tumor shrinkage.…

This study tested whether bupropion, a medication often used for depression, can improve low sexual desire in women who have had breast or gynecologic cancer. About 230 women took either bupropion or a placebo pill for 9 weeks. The goal was to see if the drug could safely boost d…

This study looked at whether using saliva instead of blood can help monitor cytomegalovirus (CMV) infection in people being treated for ovarian cancer. Researchers collected saliva and blood samples from 49 participants, both in clinic and at home. The goal was to see if remote s…

This study looked at how muscle cells produce energy in women with ovarian or endometrial cancer who have lost weight. Researchers compared women of different body sizes (BMI) to see if muscle metabolism differs. The goal was to better understand the biology behind cancer-related…