OVARIAN CARCINOMA

This study tested a combination of two drugs, olaparib and cediranib, in 70 people with ovarian, peritoneal, or fallopian tube cancer that had returned after initial treatment. The goal was to see if the drugs could slow or stop tumor growth by blocking enzymes cancer cells need …

This study tests a drug called sacituzumab govitecan in 20 people with ovarian, fallopian tube, or peritoneal cancer that has stopped responding to platinum-based chemotherapy. The drug works like a guided missile, delivering chemotherapy directly to cancer cells. The main goal i…

This early-phase study tests a drug called veliparib combined with two standard chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors who also have liver or kidney dysfunction. The main goals are to find the safest dose and understand how the body p…

This study tests whether adding heated chemotherapy directly into the abdomen during surgery helps people with advanced ovarian cancer live longer without the disease coming back. About 362 participants will either get standard surgery alone or surgery plus the heated chemo. The …

This is a first-in-human study to test the safety and find the right dose of an experimental pill called ATV-1601. It is for adults with advanced solid tumors, including certain breast, gynecologic, and prostate cancers, that have a specific genetic change called an AKT1 E17K mut…

This study compares two imaging methods—PET/MR and standard CECT scans—to see which better locates ovarian cancer tumors and predicts if they can be fully removed by surgery. About 21 women with known or suspected ovarian cancer will receive both scans. The goal is to improve sur…

This study looks at three approaches for women with BRCA mutations who are at high risk for ovarian cancer: regular screening, removing both fallopian tubes and ovaries at once, or removing just the tubes first and the ovaries later. The goal is to see if delaying ovary removal h…

This study tests whether eating a diet high in magnesium can prevent low blood magnesium levels in ovarian cancer patients receiving carboplatin chemotherapy. About 26 women with previously untreated ovarian cancer will follow a magnesium-rich diet for up to 6 cycles of treatment…

This study tests different programs to help people at high risk for cancer eat healthier and exercise more. The goal is to see which approach works best to increase physical activity and improve diet. About 337 people with a high BMI, low activity, or poor diet are taking part. T…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study tests a web-based education tool called HOPE-Genomics that helps cancer patients learn about their genetic test results. About 465 adults with certain cancers (breast, lung, colorectal, and others) will use the tool to see if it improves their understanding of genomics…

This study checks for muscle loss (sarcopenia) in 25 women with advanced ovarian cancer before they start chemotherapy. Researchers use CT scans to measure muscle mass and see how it relates to treatment timing. The goal is to better understand how muscle health affects care, not…

This study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. Researchers will store and study these samples over time to learn how cancer changes and why some treatments stop working. The goal is to improve future …

This study looked at whether regular screening tests can help find ovarian cancer early and reduce the number of women who die from it. Over 78,000 women aged 55 to 74 took part. Researchers compared women who got screening tests to those who got usual care to see if screening ma…