MYELODYSPLASTIC SYNDROMES

This study looked at 88 adults in China with a type of blood cancer called lower-risk myelodysplastic syndromes (MDS). All patients received a drug called luspatercept. The goal was to see if it helped them need fewer blood transfusions and raised their hemoglobin levels. The stu…

This study tested a combination of chemotherapy (busulfan and etoposide) and low-dose total body radiation before a donor bone marrow transplant in 30 people with advanced leukemia or myelodysplastic syndromes. The goal was to see how well this approach helped patients survive ca…

This study tested whether the drug palifermin could make stem cell transplants from unrelated donors safer and more effective for people with blood cancers like leukemia or lymphoma. 34 adults received palifermin before transplant to see if it would reduce severe graft-versus-hos…

This study tested whether adding the drug VIC-1911 to standard medications can prevent graft-versus-host disease (GVHD) and cancer relapse after a stem cell transplant. Sixteen adults with blood cancers like leukemia or lymphoma took part. Researchers looked for the best dose of …

This study tested a stem cell transplant using a half-matched family donor for people with various blood cancers. The treatment used a milder chemotherapy and radiation regimen to prepare the body for the transplant. The goal was to see how many patients remained cancer-free 18 m…

This study looked at a new way to do bone marrow transplants for people with hard-to-treat blood cancers like leukemia and lymphoma. It tested replacing a standard drug (cyclophosphamide) with another drug (bendamustine) after transplant to see if it could reduce side effects and…

This study tested a new type of stem cell transplant called microtransplantation in 25 adults with myeloid blood cancers (acute myeloid leukemia or myelodysplastic syndromes) who could not have a standard transplant. Unlike regular transplants, this approach uses partially matche…

This study tested the drug dasatinib in 68 adults with several types of blood and bone marrow disorders, including certain leukemias, myelofibrosis, and mastocytosis. The goal was to see if dasatinib could help control the disease and to check its safety. Participants took dasati…

This early-phase study tested a new drug called JNJ-74856665 in 153 adults with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), or chronic myelomonocytic leukemia (CMML) who had not responded to other treatments. The main goals were to find safe doses and understan…

This early-phase study tested a combination of two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard treatments. The main goal was to find the safest dose and check fo…

This early-phase trial tested a drug called ONC-201 in 20 people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who had recently received a stem cell transplant. Participants took the drug as a weekly pill for one year to see if it was safe and coul…

This study tested a drug called luspatercept in 30 adults from China and Japan who have a bone marrow disease (MDS) with ring sideroblasts and need regular red blood cell transfusions. The goal was to see if the drug could help them go without transfusions for at least 8 weeks. T…

This study tested whether adding the drug tocilizumab to standard care could reduce the risk of graft-versus-host disease (GVHD) after a cord blood transplant in adults with blood cancers. GVHD is a serious complication where donor cells attack the patient's body. Tocilizumab blo…

This study tested whether giving the antibiotic levofloxacin can prevent dangerous fevers and infections in people with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who are being treated with azacitidine. Sixty adults took part, and half received levofloxacin w…

This early-phase study tested a new oral drug called NTX-301 in 22 adults with blood cancers like acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that had not responded to prior treatments. The main goal was to check safety and find the right dose. Researchers als…

This study looked at a lower dose of the drug ASTX727 given on different schedules to 160 adults with lower-risk myelodysplastic syndromes (MDS), a type of blood cancer. The goal was to find a dose that improves blood cell counts and reduces side effects. The study was completed …

This early-stage study tested a new drug called JNJ-64619178 in 114 people with advanced cancers, including lymphoma, solid tumors, and myelodysplastic syndromes. The main goal was to find the safest dose and check for side effects. The drug works by blocking a protein that helps…

This study tested an experimental treatment for people with myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) whose first therapy stopped working. Nineteen adults received a special infusion of immune cells from a mismatched unrelated donor, designed to att…

This study tested a new way to help people with blood cancers (like leukemia or lymphoma) get into hospice care earlier. Normally, hospice doesn't cover blood transfusions, so patients delay hospice to keep getting them. The study paid for transfusions while patients were on hosp…

This study looked at 1,753 patients with blood cancers or other blood disorders who needed a stem cell transplant. Researchers compared two strategies: first searching for a matched unrelated donor and then an alternative donor if needed, versus going straight to an alternative d…

This study looked back at medical records of 418 adults with lower-risk myelodysplastic syndromes (MDS) who had not previously received certain anemia treatments. Researchers wanted to see how doctors actually use luspatercept and how patients respond in everyday practice. The go…

This study tested whether a telehealth program could help older patients (60+) with acute myeloid leukemia or myelodysplastic syndrome discuss and document their future medical wishes. Researchers enrolled 36 patients, caregivers, and clinicians to see if the program was easy to …

This study looked at 650 adults with acute leukemia, myelodysplastic syndromes, or myeloproliferative disorders. Researchers collected blood, bone marrow, skin, and cheek samples to study genetic, epigenetic, and immune features. The goal was to find factors that predict how the …

This study looked at how often people with certain blood cancers or related conditions have an acquired deficiency of an enzyme called pyruvate kinase, which can cause anemia. Researchers took a single blood sample from 18 participants to measure enzyme activity and check for rel…

This study looked at how the immune system recovers after a stem cell transplant for blood cancers like leukemia. Researchers measured the function of immune cells (T and NK cells) in 61 adult patients to see how it relates to infections, relapse, and graft-versus-host disease. T…

This study followed 349 adults with myelodysplastic syndromes (MDS), a bone marrow disorder that raises the risk of leukemia. Researchers used DNA testing to find gene changes and see how they affected survival and treatment response. The goal was to better understand the disease…