MYELODYSPLASTIC SYNDROMES

This study tests whether giving personalized maintenance therapy after a stem cell transplant can prevent cancer from coming back in people with certain blood cancers. About 450 adults with myeloid cancers who have signs of disease before transplant will be assigned to treatment …

This early-phase study tests a new tablet, FXS0683, in about 228 adults with certain blood cancers (like lymphoma, leukemia, or myelodysplastic syndromes) that have returned or not improved after standard treatments. The main goals are to find a safe dose and see if the drug can …

This study tests a new drug called TAK-226 in 27 Japanese adults with a bone marrow condition called myelodysplastic syndromes (MDS) who need regular blood transfusions. The goal is to see if the drug can help them go without transfusions for at least 8 weeks. Participants will r…

This study tests whether it is safe and feasible for certain patients to stop taking tacrolimus, an anti-rejection drug, early after a stem cell transplant. The goal is to reduce side effects while still preventing graft-versus-host disease (GVHD). About 50 adults with blood canc…

This study tests a new two-drug combination (pacritinib plus azacitidine) for people with moderate to very high risk myelodysplastic syndrome (MDS), a bone marrow disorder. The first part finds the safest dose of pacritinib, and the second part checks how well the combination wor…

This study tests an oral drug called chidamide in 15 people aged 60 or older with intermediate-to-high-risk myelodysplastic syndromes (MDS), a bone marrow disorder that can lead to leukemia. The goal is to see if chidamide can improve blood cell counts and control the disease wit…

This study tests whether the drug interferon-α can lower the chance of cancer returning in people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who have a TP53 gene mutation. Participants must have had a stem cell transplant and show no signs of cancer two m…

This study tests an experimental drug called BL-M11D1 in people with a blood cancer called myelodysplastic syndromes (MDS) that has returned or stopped responding to standard treatments. The goal is to find a safe dose and see if the drug can shrink or control the cancer. About 9…

This study tests an online music therapy program that combines mindfulness and music to help people recovering from stem cell transplants for blood cancers. Researchers want to see if it can improve quality of life, reduce pain, fatigue, anxiety, and depression, and possibly spee…

This study will follow 5,000 adults with immune system problems to see if they also have hidden blood cell mutations (clonal hematopoiesis), including the rare VEXAS syndrome. Researchers aim to track how often these immune issues appear with blood disorders. No new treatments ar…

This study explores whether a non-invasive, painless skin measurement called electrical bioimpedance can help monitor acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). About 25 adults who are already scheduled for a bone marrow biopsy will also receive this skin te…