IMMUNOTHERAPY

This study is testing whether combining intermittent fasting with standard immunotherapy helps fight advanced lung cancer better. Researchers want to see if a special fasting diet makes cancer cells more vulnerable to treatment while reducing side effects. The trial involves 66 p…

This study is testing if adding a type of immunotherapy drug (a PD-1 inhibitor) as a long-term maintenance treatment after standard chemoradiation helps people with locally advanced esophageal cancer live longer without their cancer getting worse. It will involve 452 adults and i…

This study is testing a combination of radiation, chemotherapy, and two immunotherapy drugs given before surgery for stomach cancer. The goal is to see if this approach can shrink or eliminate the tumor to make surgery more successful. Researchers will compare two different order…

This study is testing whether combining three drugs—paclitaxel (or nab-paclitaxel), pembrolizumab, and mirabegron—can help control recurrent ovarian cancer. It aims to see if this combination shrinks tumors and is safe for patients. The trial will involve about 20 adults whose ca…

This study is testing if adding a specific probiotic supplement (Probio-M9) to a standard treatment plan improves results for people with locally advanced rectal cancer. All participants will receive chemotherapy, radiation, and an immunotherapy drug (tislelizumab). Researchers w…

This study is testing whether sorbitol, a common sugar alcohol, can improve the effectiveness of standard chemotherapy and immunotherapy for locally advanced stomach cancer. Researchers will compare sorbitol against a placebo in 80 patients who will receive the treatment for 3 mo…

This large study aims to find the best pre-surgery treatment combination for patients with esophageal cancer, which has a low survival rate. Researchers will compare different approaches, including chemotherapy, radiation, immunotherapy, and targeted drugs, given before surgery. …

This study is testing whether a new cell therapy called RAK, made from umbilical cord blood, can help control advanced stomach cancer that has stopped responding to standard treatments. Researchers will compare the therapy against a control group in 90 patients to see if it exten…

This large study aims to find the best treatment combination for patients with esophageal or stomach junction cancer that cannot be surgically removed. Researchers will test whether adding newer immunotherapy drugs or targeted therapies to standard chemotherapy and radiation impr…

This study is testing a new combination of four drugs for people with an aggressive type of advanced stomach or gastroesophageal cancer that has continued to grow despite initial treatment with immunotherapy and chemotherapy. The goal is to see if this new drug mix can shrink tum…

This study is testing whether giving immunotherapy drugs before surgery can help surgeons completely remove advanced colon tumors while preserving nearby organs. It focuses on patients whose cancer has a specific genetic feature that makes it respond poorly to standard chemothera…

This study is testing if adding two treatments—a drug called narlumosbart and precise radiation therapy—to standard first-line chemo-immunotherapy can improve results for people with advanced non-small cell lung cancer that has spread to their bones. The goal is to see if this co…

This study is testing a new treatment called VSV-02 for people with advanced solid tumors who have few or no other treatment options left. VSV-02 is a specially engineered virus designed to both kill cancer cells directly and boost the body's immune system to fight the cancer. Th…

This study is testing a new combination treatment for people with a type of stomach cancer that is advanced but hasn't spread to distant organs. The goal is to see if adding a shorter, more intense course of radiation to standard immunotherapy and chemotherapy can shrink tumors e…

This study is checking how well a venom allergy treatment works years after people finish it. Researchers are recruiting 100 Australian adults who completed a 3-6 year treatment program for Jack Jumper ant allergy. Participants will have a supervised ant sting in a hospital to te…

This study is testing a new oral drug, ABT-301, combined with two existing cancer immunotherapies (tislelizumab and bevacizumab) for people with a specific type of advanced colorectal cancer that has spread. The main goals are to find the safest dose of the new drug and see if th…

This study is testing if adding an immunotherapy drug to a new, more targeted form of radiation and standard chemotherapy works better for treating advanced esophageal cancer. Researchers will compare the new three-part combination to just the targeted radiation and chemotherapy …

This study is testing a new combination of treatments for people with locally advanced rectal cancer. The goal is to see if adding an immunotherapy drug to a standard mix of radiation, chemotherapy, and a targeted drug can better shrink tumors before surgery. Researchers will com…

This study is testing if adding a low dose of radiation to a combination of targeted and immunotherapy drugs works better than the drugs alone when given before surgery for operable head and neck cancer. The goal is to shrink the tumor more effectively to improve surgical outcome…

This study is testing a new diagnostic platform that uses artificial intelligence to analyze small pieces of a patient's tumor. The goal is to predict whether a patient's cancer will respond to immunotherapy drugs before they start treatment. Researchers will compare the AI's pre…

This study aims to see if a simple blood test, called a liquid biopsy, can predict how well patients with head and neck cancer will respond to immunotherapy. Researchers will compare results from the blood test to traditional tissue biopsies and track how patients' cancers respon…

This study follows 500 lung cancer patients who receive immunotherapy drugs before surgery. Researchers want to learn which surgical approach works better after this treatment and whether surgery provides more benefit than radiation. The study tracks patients' long-term health an…

This study collects tumor tissue samples from cancer patients to research whether laboratory tests can predict which patients will respond to immunotherapy drugs. Researchers will analyze how live tumor samples react to immunotherapy treatments in the lab, then compare those resu…

This study aims to learn how certain markers in the blood change when cancer patients receive immunotherapy. Researchers will collect blood samples from 300 participants before and after their treatment to measure these markers. The goal is to gather knowledge that could help und…

This study aims to develop a new, non-invasive way to monitor lung cancer patients after surgery to see if the cancer might come back. Researchers will collect blood samples from 100 patients who have had lung cancer surgery and analyze them using advanced computer programs. The …

This study aims to understand if a patient's emotional state affects how well they respond to a specific combination treatment for advanced liver cancer. Researchers will observe 90 patients receiving standard therapy, grouping them by their mood scores, and track their health ou…