IMMUNOTHERAPY

This study is testing if giving an immunotherapy drug called atezolizumab before surgery to remove liver cancer can help prevent the cancer from returning. Researchers want to see if boosting the patient's immune system before the operation is more effective than surgery alone. T…

This study is testing whether adding a structured 12-week exercise program to standard immunotherapy can help patients with non-small cell lung cancer. It will compare two different types of exercise training to standard advice to see if exercise improves how well the cancer trea…

This large national study aims to see if adding immunotherapy drugs to the standard pre-surgery treatment (chemotherapy and radiation) works better for people with high-risk rectal cancer. It will also compare two different lengths of radiation treatment. The goal is to shrink tu…

This study aims to understand why some patients with a specific type of stomach cancer respond well to immunotherapy while others do not. It will enroll 15 Asian patients with this cancer type who are scheduled for surgery after receiving immunotherapy. The goal is to learn what …

This study is testing if adding a dietary supplement called β-hydroxybutyrate (a type of ketone) to a standard combination of short radiation, chemotherapy, and immunotherapy can improve results for people with locally advanced rectal cancer. It will involve 48 adults who have no…

This study is testing if adding a special, short-course radiation schedule to a new immunotherapy drug and standard chemotherapy can better control advanced lung cancer. It will involve about 104 adults with a specific type of lung cancer that has spread and lacks certain genetic…

This study aims to find the best way to keep advanced bile duct cancer under control after initial treatment. It will test different drug combinations in 160 patients whose cancer responded to first-line therapy. The goal is to see which approach keeps the cancer from growing lon…

This study aims to see if one of two different drug combinations can help shrink tumors before surgery for people with a specific type of advanced stomach or gastroesophageal cancer. About 30 participants will be randomly assigned to receive either an immunotherapy drug plus chem…

This study is testing whether a combination of two immunotherapy drugs can shrink tumors enough to avoid surgery in women with a specific, surgically removable type of endometrial cancer. It will enroll about 30 women who have not had recent cancer treatment. The main goal is to …

This study is testing if combining two standard treatments works better for advanced liver cancer that cannot be removed by surgery. It will give 90 patients both a drug that boosts the immune system and a procedure that directly targets the tumor in the liver. The goal is to see…

This study is testing a new two-part treatment for aggressive soft tissue cancers in the abdomen (retroperitoneal sarcoma). Doctors want to see if giving a short, intense course of radiation therapy combined with immunotherapy drugs before surgery is safe and feasible. The goal i…

This study is testing whether giving an immunotherapy drug (pembrolizumab) before surgery can shrink tumors enough to allow some patients with a specific type of early-stage colon cancer to avoid major surgery. The goal is to see if patients whose cancer disappears after the drug…

This study is testing if adding a specific probiotic (Lactobacillus johnsonii) to standard chemotherapy and immunotherapy helps people with certain advanced cancers. It will enroll 156 adults with advanced lung, breast, or stomach cancer that has progressed after prior immunother…

This study is testing whether a urine test that detects cancer DNA can help doctors decide when to safely stop immunotherapy in patients with a high-risk form of bladder cancer that cannot be fully removed by surgery. About 53 patients will receive immunotherapy and be monitored …

This study is testing whether a remote monitoring system using a Fitbit and weekly symptom surveys can help patients better manage side effects during cancer immunotherapy. Researchers want to see if this digital tool is easy for patients to use and if it improves their quality o…

This observational study aims to understand how immunotherapy affects physical fitness and quality of life in adults with advanced solid cancers. Researchers will measure fitness and quality of life before and during standard immunotherapy treatment to see if a patient's fitness …

This study is testing a new automated blood test that measures immune cell activity to see if it can predict how well standard immunotherapy works for patients with advanced solid tumors. Researchers will enroll 100 adults about to start immunotherapy to see if the test results c…