DIFFUSE INTRINSIC PONTINE GLIOMA
Clinical trials for DIFFUSE INTRINSIC PONTINE GLIOMA explained in plain language.
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Could a vaccine fight childhood brain cancer? new trial hopes so.
⭐️ VACCINE ⭐️ Recruiting nowThis study tests a vaccine called PEP-CMV in 120 children and young adults with certain aggressive brain tumors (high-grade glioma, DIPG, or recurrent medulloblastoma). The vaccine targets a common virus (CMV) found in these tumors, aiming to train the immune system to attack the…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE2 • Sponsor: Nationwide Children's Hospital • Aim: ⭐️ VACCINE ⭐️
Last updated May 17, 2026 02:00 UTC
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Engineered t cells take on childhood brain cancers in new trial
Disease control Recruiting nowThis early-phase study tests a new gene therapy for people with aggressive brain tumors that have a protein called GD2. Researchers take a patient's own T cells, add a special receptor to help them recognize and attack GD2 on cancer cells, plus a gene that helps the T cells live …
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated May 17, 2026 02:05 UTC
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Targeted brain tumor treatment offers new hope for kids
Disease control Recruiting nowThis study tests whether giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and works for children and young adults under 22 whose brain tumors have come back or not responded to treatment. About 20 participants will rec…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1, PHASE2 • Sponsor: University of Miami • Aim: Disease control
Last updated May 17, 2026 02:04 UTC
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Sound waves open Brain's shield to attack deadly childhood tumors
Disease control Recruiting nowThis early-stage study tests whether a non-invasive ultrasound technique can temporarily open the blood-brain barrier in children with progressive diffuse midline glioma (DMG), a rare and aggressive brain tumor. The goal is to let more of the oral chemotherapy drug etoposide reac…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1 • Sponsor: Columbia University • Aim: Disease control
Last updated May 17, 2026 02:03 UTC
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Promising drug cocktail targets tough brain cancers in kids
Disease control Recruiting nowThis study tests two drug combinations given after radiation for children and young adults with aggressive brain tumors (high-grade glioma or DIPG). One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The goal is to see if these combinations …
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE2 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated May 17, 2026 02:02 UTC
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New hope for kids with rare cancers: drug combo trial launches
Disease control Recruiting nowThis study tests an experimental oral drug called AMXT 1501 combined with another drug, eflornithine (DFMO), in children and young adults up to age 21 with certain cancers like neuroblastoma, brain tumors, and sarcomas. The first part finds the safest dose, and the second part ch…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1, PHASE2 • Sponsor: Milton S. Hershey Medical Center • Aim: Disease control
Last updated May 17, 2026 02:01 UTC
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New drug hope for kids with rare brain tumors
Disease control Recruiting nowThis study tests the drug lorlatinib in children (ages 1 to 21) with a newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given with or after other …
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: EARLY_PHASE1 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated May 17, 2026 02:00 UTC
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New hope for kids with rare brain tumors: adaptive trial tests drug cocktails
Disease control Recruiting nowThis study tests whether combining the drug ONC201 with other new agents can help children and young adults with diffuse midline gliomas (DMGs), including DIPG. The trial uses an adaptive design, meaning new drug combinations can be added as research evolves. About 360 participan…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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New hope for kids with DIPG: major trial launches
Disease control Recruiting nowThis phase 3 trial tests whether the drug ONC201 works better than everolimus for children with diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor. About 433 participants will be randomly assigned to one of the two drugs, and if their disease gets worse, t…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE3 • Sponsor: Gustave Roussy, Cancer Campus, Grand Paris • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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New hope for kids with rare brain cancer: targeted drug shows promise
Disease control Recruiting nowThis study tests a drug called larotrectinib in children (up to age 21) with a rare, aggressive brain tumor (high-grade glioma) that has a specific genetic change (NTRK fusion). The goal is to see if the drug can shrink or control the tumor after two cycles, and to check its safe…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: EARLY_PHASE1 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated May 14, 2026 12:02 UTC
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Engineered immune cells injected directly into the brain show promise for childhood cancers
Disease control Recruiting nowThis early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated May 13, 2026 15:59 UTC
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New vaccine combo aims to fight deadly childhood brain tumors
Disease control Recruiting nowThis early-phase trial tests a new vaccine (rHSC-DIPGVax) combined with two immunotherapy drugs (BALSTILIMAB and ZALIFRELIMAB) in children with diffuse intrinsic pontine glioma (DIPG) or diffuse midline glioma (DMG). The vaccine is designed to help the immune system recognize and…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1 • Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Disease control
Last updated Apr 29, 2026 15:02 UTC
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Brain tumor genetics could unlock personalized treatments for kids
Knowledge-focused Recruiting nowThis study is for children, teens, and young adults (ages 1 to 39) newly diagnosed with a high-grade glioma, a serious type of brain tumor. Researchers will analyze the tumor's genetic makeup to see if it matches a specific treatment plan in a future study. The goal is to learn m…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Sponsor: Nationwide Children's Hospital • Aim: Knowledge-focused
Last updated May 17, 2026 02:15 UTC
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Global effort to unlock secrets of rare childhood brain tumors
Knowledge-focused Recruiting nowThis study creates a worldwide database of medical information and tumor samples from people with DIPG or DMG, rare and aggressive brain tumors. Researchers aim to learn how these tumors work at a molecular level to help design better treatments in the future. Anyone diagnosed wi…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated May 15, 2026 11:53 UTC