DIFFUSE INTRINSIC PONTINE GLIOMA
Clinical trials for DIFFUSE INTRINSIC PONTINE GLIOMA explained in plain language.
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Supercharged immune cells take aim at deadly childhood brain cancers
Disease control Recruiting nowThis early-stage trial is testing a new type of cell therapy for aggressive brain tumors that have returned or stopped responding to standard treatments. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to better recognize and attack cancer ce…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Apr 01, 2026 20:26 UTC
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Scientists use sound waves to unlock brain barrier for child cancer treatment
Disease control Recruiting nowThis early-stage study is testing whether a non-invasive focused ultrasound device can safely and temporarily open the protective blood-brain barrier in children with progressive diffuse midline glioma, a severe brain tumor. The goal is to allow more of an oral chemotherapy drug …
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1 • Sponsor: Columbia University • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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New hope for kids with deadly brain cancers: experimental vaccine trial opens
Disease control Recruiting nowThis study is testing a new vaccine designed to train the immune system to fight aggressive brain cancers in children and young adults. It will enroll about 120 patients aged 3 to 39 with newly diagnosed high-grade glioma, diffuse intrinsic pontine glioma (DIPG), or recurrent med…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE2 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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Race for a better treatment for devastating childhood brain cancer
Disease control Recruiting nowThis large, international Phase 3 trial aims to find a better treatment for diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor with very few options. It will compare two drugs, ONC201 and everolimus, in over 430 patients, including children and adults, to …
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE3 • Sponsor: Gustave Roussy, Cancer Campus, Grand Paris • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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New hope for kids with devastating brain tumors: trial tests flexible drug combinations
Disease control Recruiting nowThis trial is testing new drug combinations for children and young adults with aggressive brain tumors called diffuse midline gliomas (DMGs), which currently have very few treatment options. It uses a flexible 'platform' design to test different drug combinations, including ONC20…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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New hope for kids with deadly brain tumors: trial matches treatment to tumor genetics
Disease control Recruiting nowThis study aims to find better treatments for children and young adults newly diagnosed with aggressive brain tumors. Researchers will analyze the genetic makeup of each patient's tumor to match them with a targeted therapy that might work best for their specific cancer. The goal…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New hope for kids with tough cancers: Two-Drug attack enters trial
Disease control Recruiting nowThis study is testing a new oral drug, AMXT 1501, combined with an existing drug called DFMO, for children and young adults with aggressive cancers that have come back or didn't respond to standard treatments. The first part aims to find a safe dose, and the second part will comp…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1, PHASE2 • Sponsor: Milton S. Hershey Medical Center • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Targeted drug trial offers hope for children with aggressive brain cancer
Disease control Recruiting nowThis study is testing a targeted drug called lorlatinib in children and young adults (ages 1-21) newly diagnosed with aggressive brain tumors (high-grade gliomas) that have specific genetic changes called ALK or ROS1 fusions. The main goals are to see if the drug can control the …
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: EARLY_PHASE1 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated Mar 27, 2026 12:37 UTC
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New hope for kids with devastating brain cancer: First-in-Human vaccine trial begins
Disease control Recruiting nowThis is a first-in-human safety study testing a new, 'off-the-shelf' cancer vaccine combined with two immunotherapy drugs for children with DIPG and DMG, aggressive brain tumors with very few treatment options. The trial aims to see if this combination is safe and tolerable for c…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1 • Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New hope for kids with devastating brain cancer: trial tests Life-Extending drug combos
Disease control Recruiting nowThis study is testing two different drug combinations to see if they can help children and young adults with aggressive brain tumors live longer. The trial is for patients who have just finished radiation therapy. One group receives two drugs (ribociclib and everolimus), while an…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE2 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New hope for kids with rare, deadly brain cancer?
Disease control Recruiting nowThis early-stage study is testing a drug called larotrectinib in children and young adults (up to age 21) newly diagnosed with aggressive brain tumors that have a specific genetic feature called an NTRK fusion. The main goals are to see if the drug can control the tumor and to ch…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: EARLY_PHASE1 • Sponsor: Nationwide Children's Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:19 UTC
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Doctors test Direct-to-Brain cell therapy for Kids' devastating tumors
Disease control Recruiting nowThis early-stage study is testing a new cell therapy for children and young adults with aggressive or returning brain tumors. Doctors collect a patient's own immune cells, engineer them in a lab to target a protein (B7H3) found on tumor cells, and then deliver these 'CAR T cells'…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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New hope for kids with tough brain tumors: targeted treatment trial
Disease control Recruiting nowThis study is testing a new way to deliver cancer drugs directly to the brain for children and young adults whose brain tumors have come back or haven't responded to standard treatments. Doctors use a tiny catheter to deliver two existing drugs (cetuximab and bevacizumab) precise…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Phase: PHASE1, PHASE2 • Sponsor: University of Miami • Aim: Disease control
Last updated Mar 10, 2026 12:54 UTC
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Global effort launched to crack the code of devastating childhood brain cancer
Knowledge-focused Recruiting nowThis study is creating a worldwide database and tissue bank for patients diagnosed with DIPG or DMG, which are rare and aggressive brain tumors primarily affecting children. Researchers are collecting medical records, scans, and tumor samples from up to 1,500 patients to better u…
Matched conditions: DIFFUSE INTRINSIC PONTINE GLIOMA
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Mar 17, 2026 13:09 UTC