CHRONIC MYELOMONOCYTIC LEUKEMIA
Clinical trials for CHRONIC MYELOMONOCYTIC LEUKEMIA explained in plain language.
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New antibody drug tested in fight against aggressive blood cancers
Disease control OngoingThis early-phase study is testing a new antibody drug called bexmarilimab in combination with standard cancer therapies. It aims to find a safe dose and see if the combination helps adults with advanced forms of blood cancers like myelodysplastic syndrome (MDS) and acute myeloid …
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: Faron Pharmaceuticals Ltd • Aim: Disease control
Last updated Apr 01, 2026 21:41 UTC
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Health check tailors cancer transplant for seniors
Disease control OngoingThis study is testing whether a detailed health assessment can help doctors personalize the intensity of a stem cell transplant for older adults (age 60+) with certain blood cancers. The assessment looks at factors like thinking skills, physical ability, and mood to decide if a p…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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New oral pill enters first human trial for Tough-to-Treat blood cancers
Disease control OngoingThis is the first study in people to test a new oral pill called NTX-301. It aims to see if the drug is safe and can help control advanced forms of leukemia and related blood cancers that have come back or stopped responding to other treatments. The study will enroll about 22 adu…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New transplant strategy aims to tame tough blood cancers
Disease control OngoingThis study is testing a two-drug chemotherapy regimen followed by a donor stem cell transplant for adults with certain blood cancers that are in remission or at high risk. The goal is to see if this approach can better control the disease and prevent it from coming back after the…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New drug duo aims to control aggressive blood cancers
Disease control OngoingThis study is testing the safety and effectiveness of combining two drugs, vorinostat and azacitidine, for patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). The goal is to find the best dose and see if the combination can better control the disease by…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Blood cancer patients get extended access to promising treatment
Disease control ENROLLING_BY_INVITATIONThis study allows patients with certain blood cancers who were benefiting from ASTX727 treatment in previous trials to continue receiving the medication. The main goal is to collect long-term safety information about the drug. Participants will receive the same dose they were tak…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Taiho Oncology, Inc. • Aim: Disease control
Last updated Mar 31, 2026 12:11 UTC
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Could a safer dose after transplant help blood cancer patients recover with fewer infections?
Disease control OngoingThis study is testing if using a lower dose of a standard drug (cyclophosphamide) given after a stem cell transplant can reduce serious infections in the first 100 days. The trial aims to see if this lower dose is just as good at preventing graft-versus-host disease, a common and…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Experimental immune therapy tested for leukemia patients whose cancer returned after transplant
Disease control OngoingThis early-stage trial is testing whether a combination of two immune-based treatments is safe for patients whose blood cancer has returned after a stem cell transplant. The study involves 25 adults with conditions like acute myeloid leukemia or myelodysplastic syndromes. Researc…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE1 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Scientists test drug combo to fight tough blood cancer
Disease control OngoingThis study is testing if adding a drug called pomalidomide to standard chemotherapy works better for adults newly diagnosed with a specific, harder-to-treat type of acute myeloid leukemia (AML). About 50 participants will be randomly assigned to receive either the standard chemo …
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Oral combo therapy trial aims to control aggressive blood cancers
Disease control OngoingThis study is testing if a two-drug oral combination works better than a single oral drug to control symptoms and reduce cancer cells in patients with certain aggressive blood cancers, including chronic myelomonocytic leukemia (CMML). It is a Phase 2 trial with 132 participants, …
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New Triple-Threat treatment tested for aggressive blood cancers
Disease control OngoingThis study is testing a combination of three drugs—azacitidine, venetoclax, and pevonedistat—for adults newly diagnosed with certain high-risk blood cancers. These include acute myeloid leukemia (AML) that developed from other blood disorders or prior cancer treatment, as well as…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New drug trial aims to tame rare blood cancer
Disease control OngoingThis study is testing whether the drug ruxolitinib can help control Chronic Myelomonocytic Leukemia (CMML), a rare blood cancer. Researchers are enrolling 29 adults with CMML who have significant symptoms or an enlarged spleen. The main goal is to see if the treatment reduces sym…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New hope for tough blood cancers: testing a powerful drug duo
Disease control OngoingThis study is testing a combination of two drugs for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or hasn't responded to other treatments. The goal is to see if the combination is safe and effective at controlling the dis…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 25, 2026 14:09 UTC
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Race to find better treatment for High-Risk blood cancers
Disease control OngoingThis study is testing whether adding one of two other drugs (lenalidomide or vorinostat) to the standard chemotherapy drug azacitidine works better for people with higher-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The goal is to see which comb…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 24, 2026 12:01 UTC
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New Two-Drug attack on tough blood cancers
Disease control OngoingThis study is testing a two-drug combination for adults with certain advanced blood cancers, including chronic myelomonocytic leukemia (CMML). The goal is to find the safest and most effective dose of a targeted drug (tagraxofusp) that delivers a toxin directly to cancer cells, c…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 24, 2026 12:01 UTC
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Scientists test 'Double Hit' combo against tough blood cancers
Disease control OngoingThis study is testing if adding a new drug called veliparib to a standard two-drug chemotherapy works better for people with advanced blood cancers that have spread and are hard to treat. It will compare the two-drug combo with the three-drug combo in about 25 participants to see…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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New combo attack on stubborn blood cancers
Disease control OngoingThis study is testing a new combination of two drugs, guadecitabine and atezolizumab, for adults with advanced myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML). It is for patients whose cancer has returned or stopped responding to standard treatments. The …
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: University of Southern California • Aim: Disease control
Last updated Mar 18, 2026 14:41 UTC
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New strategy aims to tame dangerous virus after cancer transplant
Disease control OngoingThis study is testing a personalized plan to manage cytomegalovirus (CMV), a common and potentially serious infection, in patients who have received a donor stem cell transplant for blood cancers or disorders. The plan involves closely monitoring the virus level and the patient's…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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New hope for tough blood cancers: oral combo therapy trial
Disease control OngoingThis study is testing a new combination of three oral cancer drugs for people with high-risk forms of two blood cancers (MDS and CMML) who haven't had treatment before. The first part aims to find the safest dose, and the second part measures how well the combination works to con…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 16, 2026 15:25 UTC
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Major trial tests if adding a hormone boosts blood cell Drug's power
Disease control OngoingThis large, late-stage trial is comparing two treatment approaches for patients with a bone marrow disorder (MDS) and severe anemia. It tests whether a drug called lenalidomide works better alone or when combined with a hormone (epoetin alfa) that helps the body make red blood ce…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 16, 2026 15:23 UTC
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Scientists probe shared link between severe COVID and blood cancers
Knowledge-focused TerminatedThis study aimed to understand how severe COVID-19 disrupts the body's ability to make new blood cells, a process called emergency hematopoiesis. Researchers planned to compare blood cell samples from three groups: patients with severe COVID-19, patients with certain chronic bloo…
Matched conditions: CHRONIC MYELOMONOCYTIC LEUKEMIA
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC