Psoriatic arthritis

This study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…

This study is testing two injectable drugs, ustekinumab and guselkumab, in 50 children with active juvenile psoriatic arthritis. The goal is to see how well the drugs work, how they move through the body, and if they are safe. Participants will receive one of the drugs and be mon…

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in …

This trial tests whether a brief vocational rehabilitation program can help people with arthritis who are worried about losing their jobs. Participants, all currently employed and living or working in eastern Massachusetts, will work with a physical or occupational therapist to i…

This study tested whether combining two drugs (guselkumab and golimumab) works better than one drug alone for people with active psoriatic arthritis who didn't get enough relief from previous TNF-alpha blockers. 91 adults took part. The goal was to see if the combo could help mor…

This Phase 3 trial tested bimekizumab, a drug given by injection, against a placebo in 400 adults with active psoriatic arthritis who had not responded well to TNF-alpha inhibitors. The study aimed to see if bimekizumab could reduce joint pain and swelling and improve daily funct…

This study tested a drug called bimekizumab in 852 adults with active psoriatic arthritis, a condition causing joint pain, swelling, and skin patches. Participants received either bimekizumab, a placebo, or an existing treatment (adalimumab). The main goal was to see if bimekizum…

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizu…

This study looked at the long-term safety and effectiveness of bimekizumab in adults with active psoriatic arthritis. Over 1,100 people who completed earlier studies received the drug and were monitored for side effects and disease symptoms. The goal was to see if bimekizumab rem…

This study tests whether bimekizumab works better than risankizumab for adults with active psoriatic arthritis (PsA), a condition causing joint pain and skin lesions. About 684 participants will receive one of the two drugs for 16 weeks. The main goal is to see who gets at least …

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This Phase 3 study tested guselkumab, a drug given by injection, in 741 adults with active psoriatic arthritis. The goal was to see if it reduces joint pain and swelling. Participants received either guselkumab or a placebo. The main measure was a 20% improvement in arthritis sym…

This study tested whether adding a weight-loss drug (tirzepatide) to a standard arthritis drug (ixekizumab) helps people with psoriatic arthritis who are overweight or obese. 279 adults with active psoriatic arthritis and a BMI of 27 or higher took part. The goal was to see if th…

This study tracked over 2,300 adults in Korea who were prescribed Skyrizi (risankizumab) for moderate to severe plaque psoriasis or psoriatic arthritis. Researchers monitored side effects and symptom changes for 52 weeks during routine doctor visits. The goal was to confirm the d…

This study tested a new drug called bimekizumab in 567 adults with moderate to severe plaque psoriasis. Participants received either bimekizumab, a placebo, or another active drug. The main goal was to see how well bimekizumab cleared skin lesions after 16 weeks. Results showed s…

This phase 3 study tested bimekizumab, a drug given by injection, against a placebo in 435 adults with moderate to severe plaque psoriasis. The main goal was to see how many people achieved at least 90% skin clearing after 16 weeks. The trial also looked at complete clearing and …

This early-phase trial tested a new drug called VIS171 in 61 people: first in healthy volunteers, then in patients with autoimmune diseases. The main goal was to check safety and how the body processes the drug. No results on whether it actually helps the disease are available ye…

This study looked at the long-term safety and effectiveness of the Birmingham Hip Resurfacing System, a metal hip implant, in 329 adults with arthritis. The main goal was to see how many patients needed a revision (replacement or removal) within 10 years. The study also measured …

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or spine arthritis could safely switch from receiving infliximab through an IV infusion at a clinic to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This study looked at how safe and effective upadacitinib is for Korean patients with rheumatoid arthritis, atopic dermatitis, ankylosing spondylitis, or psoriatic arthritis. Over 2,300 adults took the drug as prescribed by their doctor and were followed for about 28 weeks. Resear…

This study looked at how well a specific knee replacement (balanSys UNI) works over time. 116 people with knee arthritis got the implant and were followed for at least 2 years. Doctors measured knee function using the Knee Society Score and checked X-rays for any problems.

This study looked at 70 people with psoriatic arthritis to compare two drug types: upadacitinib and IL-17 inhibitors. Researchers tracked joint and skin symptoms over 24 weeks in routine care. The goal is to see which works better in real life, helping doctors personalize treatme…

This phase 3 trial tested a single injection of tildrakizumab against placebo in 508 adults with active psoriatic arthritis who had previously used anti-TNF drugs. The main goal was to see if more people achieved at least a 20% improvement in joint symptoms. The study is now comp…

This study tested a higher dose (10 mg/kg every 8 weeks) of the drug TA-650 in 51 adults with psoriasis who had initially improved on the standard dose of Remicade but later lost that benefit. The goal was to see if the increased dose could again reduce skin symptoms. Participant…

This study tested whether adding GOLimumab to methotrexate works better than methotrexate alone for people with very early psoriatic arthritis (PsA). 84 adults with active PsA diagnosed within the last 2 years took part. The main goal was to see if the combination improved diseas…

This completed trial tested whether starting stronger medications early helps people with moderate to severe psoriatic arthritis more than the usual step-up approach. 192 adults were randomly assigned to standard care, early combination disease-modifying drugs, or early TNF inhib…

This pilot study tested whether adding metformin to standard care can slow the buildup of plaque in the carotid arteries of people with psoriatic arthritis (PsA) who do not have diabetes. Twenty-four participants with PsA and existing carotid plaque were randomly assigned to take…

This study tested two biologic drugs, secukinumab and ustekinumab, in 119 adults with active psoriatic arthritis who had not responded to or could not tolerate TNFα-inhibitor treatment. The main goal was to see which drug better improved physical function over 28 weeks. Researche…

This study looked at the long-term safety and effectiveness of the drug secukinumab in children with two types of juvenile idiopathic arthritis: juvenile psoriatic arthritis and enthesitis related arthritis. Fifty-five children who had already completed a previous study continued…

This study looked at how well the drug tofacitinib works for people with psoriatic arthritis in everyday medical practice. Over 12 months, researchers tracked 116 adults to see if the drug reduced disease activity and improved quality of life. The goal was to understand real-worl…

This study tested an oral drug called upadacitinib (RINVOQ) against a placebo and an injected drug (adalimumab/Humira) in 1705 people with active psoriatic arthritis who had not responded well to standard non-biologic treatments. The goal was to see if upadacitinib reduces joint …

This phase 3 study tested upadacitinib, an oral anti-inflammatory drug, in 642 adults with active psoriatic arthritis who had not responded well to at least one biologic treatment. Participants received either 15 mg or 30 mg of upadacitinib daily or a placebo. The main goal was t…

This completed study observed over 1,000 people with psoriasis who were prescribed OTEZLA (apremilast) for the first time. Researchers tracked side effects, symptom improvement, and quality of life over several years. The goal was to see how well the drug works in real-world sett…

This study looked at a device called GLOBAFFIN that filters antibodies from the blood to help people with autoimmune diseases. It involved 34 adults and measured how much harmful antibodies were removed and if patients felt better. The goal was to see if the device is safe and wo…

This study followed 76 adults who received a total shoulder replacement using the MIRAI modular prosthesis. Researchers measured how well the shoulder functioned and how stable the implant was over five years. The goal was to see if the implant helps patients move better and last…

This study followed 526 adults with active psoriatic arthritis who were already prescribed apremilast (Otezla) by their doctors. Researchers observed them for up to 100 weeks to see how well the drug controlled their symptoms in everyday practice. The goal was to gather long-term…

This study tested a self-guided online program for people with psoriasis. 348 adults were split into two groups: one got the app plus their regular treatment, the other got regular treatment alone. The main goal was to see if the app improved quality of life over 12 months.

This study tested whether a food formula containing medium-chain triglycerides (MCTs) and vegetable fibers could improve quality of life in 72 adults with psoriatic arthritis and low disease activity. Participants took the formula for 3 months while continuing their usual medicat…

This study looked at whether intermittent fasting (eating only during certain hours) can reduce disease severity and improve quality of life for people with psoriasis and psoriatic arthritis. Sixty overweight adults were randomly assigned to either follow an intermittent fasting …

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This pilot study looked at whether passive static stretching can increase hip flexibility in three groups: people who had hip replacement, those with long-term hip pain, and healthy volunteers. Twelve participants followed a 4-week stretching program three times a week under supe…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study tested whether two structured telemedicine visits, added between regular doctor appointments, could help people with psoriatic arthritis improve their quality of life and reduce disease impact. 101 adults with active symptoms took part. The visits focused on lifestyle …

This study tested whether an 8-week ketogenic or Mediterranean diet could reduce inflammation in 26 adults with obesity, psoriasis, and psoriatic arthritis. Participants followed one of the two diets, and researchers measured skin severity (PASI score) and joint activity (DAPSA s…

This study tested a 12-week online program called Immune Strength for people with psoriasis or psoriatic arthritis. The program provided tips on stress, sleep, nutrition, and exercise, plus one-on-one email coaching from a wellness professional. Researchers wanted to see if this …

This study compared robotic-assisted total knee replacement to the conventional technique in 95 patients with knee arthritis. The goal was to see if robotic surgery leads to better knee function, less pain, and higher satisfaction two years after the operation. Researchers also c…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study is looking at how nutrition affects disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using several different tools and compare it to how act…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study looked at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug leflunomide, used for rheumatoid and psoriatic arthritis. Researchers surveyed 302 doctors and pharmacists to see if they received and read safety materials,…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This completed study investigated whether air pollution affects flare-ups in people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis. Researchers followed 86 patients for 6 months, asking them to complete weekly questionnaires about their symptoms. They a…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This completed study looked at nearly 7,000 adults with inflammatory joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers compared two versions of a standard health survey (EQ-5D-3L and EQ-5D-5L) to see which one better measures health and quality of life…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This completed study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and to understand what factors increase that risk. Researchers …

This study aimed to create and test a decision aid for people with psoriasis or psoriatic arthritis who are starting or switching treatments. Researchers worked with 37 patients and their doctors to design a tool that supports shared decision-making. The goal was to help patients…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This study looked at fatigue in 33 adults with psoriatic arthritis or psoriasis. Researchers used questionnaires to measure tiredness and see how it relates to disease severity and treatments. The goal was to better understand fatigue and its impact on quality of life.

This study tested whether a non-invasive ultrasound device can reduce inflammation in people with inflammatory arthritis (psoriatic arthritis, rheumatoid arthritis, or ankylosing spondylitis). Sixteen participants received four sessions of focused ultrasound or a sham (placebo) t…

This completed study surveyed 229 people with chronic inflammatory rheumatism (like rheumatoid arthritis) and their doctors to find out what makes it hard to follow care recommendations after a hospital visit. The goal was to identify barriers to good outpatient management. No tr…

This study looked at 70 people with spondyloarthritis, a type of inflammatory arthritis affecting the spine and joints. Researchers measured immune markers in the blood to see if they could predict how the disease would progress or how well patients would respond to treatment. Th…

This study looked at real-world data from over 140,000 people in Sweden with rheumatoid arthritis or psoriatic arthritis. Researchers tracked how many people developed different types of cancer while taking abatacept or other arthritis drugs. The goal was to better understand the…

This completed study looked at the safety of the arthritis drug abatacept in over 38,000 people with rheumatoid or psoriatic arthritis in Denmark. Researchers used a national health registry to track rates of cancers and other side effects. The goal was to better understand the d…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This completed study followed 127 adults with moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, or non-radiographic axial spondyloarthritis who were already taking or starting secukinumab. Researchers observed them for two years to see how long the…

This early-phase study tested the safety and tolerability of a new drug called LAD191 in 69 healthy adults and people with an autoimmune disease. Researchers gave single or multiple doses to see how the body processes the drug and if it causes side effects. The goal was to gather…

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This completed study examined why people with rheumatoid arthritis (RA) and lupus have a higher risk of heart attacks. Researchers collected blood samples from 176 participants and tested how statins and adenosine A2A receptor agonists affected cholesterol balance in cells. The g…

This study checked if newer psoriasis drugs (IL17/23 inhibitors) also improve artery stiffness, a sign of heart disease. Researchers followed 66 people with moderate-to-severe psoriasis for a year, measuring pulse wave velocity (PWV) and other markers. The goal was to see if thes…

This study looked at two different designs of knee replacement implants in 60 people with arthritis. The goal was to see how much each implant moved inside the bone over two years using a special X-ray technique called RSA. The findings could help surgeons pick the better implant…