Personality disorder

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether combining transcranial magnetic stimulation (TMS) with a short emotion regulation training program can help people with borderline personality disorder (BPD) better manage their emotions. TMS aims to improve brain circuits involved in emotion control, whi…

This study tests a new therapy program called PSYCHOPATHY.COMP for male prison inmates with psychopathy. The goal is to see if 20 weeks of compassion-focused sessions can reduce psychopathic traits and improve emotional control. Researchers will compare the therapy to usual priso…

This study compares two treatments for teens aged 12-19 with oppositional defiant or conduct disorders. One group gets mentalization-based therapy (MBT), which helps teens understand their own and others' thoughts and feelings. The other group gets standard psychiatric care plus …

This trial is developing and testing a peer-led program called the Trauma Recovery Program for family members and significant others of people with borderline personality disorder. The program aims to reduce posttraumatic stress symptoms that can arise from living with or caring …

This trial investigates whether a psychological program called DBT-LIVE, which focuses on identity disturbance, can help people with borderline personality disorder (BPD). Around 112 participants will be randomly assigned to receive either DBT-LIVE or their usual treatment. Resea…

This study tests BraveBot, a computer program that talks with young people (ages 12-22) through their phone or computer while they do exposure therapy homework for anxiety or OCD. BraveBot does not replace the therapist but offers real-time coaching and encouragement during assig…

This study tests a 12-week online program designed to improve mood and motivation in people with schizophrenia or early psychosis. Participants complete 20-30 minute weekly sessions. Researchers will measure changes in symptoms and goal-directed behavior before and after the prog…

This pilot study will test whether two intravenous infusions of ketamine, given 24 hours apart, can quickly reduce symptoms in 38 adults with severe borderline personality disorder (BPD). Participants also receive standard psychiatric care. The main goal is to see if symptoms imp…

This early-stage trial will test whether psilocybin, the active ingredient in magic mushrooms, can safely reduce symptoms of obsessive-compulsive disorder (OCD). Twenty adults with moderate-to-severe OCD who haven't responded to standard treatments will receive either a low (10mg…

This study tests whether a 10-week virtual group therapy, where people write about their traumatic experiences, can reduce PTSD symptoms in adults who also have borderline personality disorder (BPD) traits. The therapy is called Group Extended Written Exposure Therapy (GE-WET). R…

This small study will test whether a type of brain stimulation called TMS can help new mothers with obsessive-compulsive disorder that started or worsened after childbirth. Fifteen women will receive 50 sessions over 10 days, along with brain scans and symptom checks. The goal is…

This pilot study will test whether a brief ear acupuncture program, delivered by specially trained nurses, is feasible and helpful for adults hospitalized with borderline personality disorder. Fifteen participants will receive five ear acupuncture sessions over nine days, in addi…

This study tests whether provoking OCD symptoms right before a gentle brain stimulation technique (tDCS) can boost its effects. About 178 adults with treatment-resistant OCD will receive either tDCS alone or tDCS preceded by symptom provocation. The goal is to see if the combined…

This study compares a new trauma-focused therapy (MBT-TF) with standard therapy for adults who have both borderline personality disorder and complex PTSD. The goal is to see if the new approach is practical and helpful for reducing symptoms. Forty participants will be followed fo…

This study tests sensorimotor psychotherapy, a body-oriented therapy, for people with personality disorders who experienced early childhood trauma. The therapy uses 12 group sessions to teach skills for regulating emotions and body responses. Researchers will compare it to standa…

This study tests whether a version of dialectical behavior therapy (DBT) that has been adapted to fit local cultures can help adults aged 18-45 with borderline personality disorder better manage their emotions and reduce self-harm. The therapy is being studied in a low- and middl…

This study tests whether a culturally adapted self-help workbook based on cognitive behavioral therapy (CBT) can help people with obsessive-compulsive disorder (OCD) in Pakistan. 108 adults with OCD will use the manual over ten weeks, with guidance from a therapist. Researchers w…

This study tests whether autobiographical rewriting workshops, added to standard therapy, can help people with borderline personality disorder (BPD) function better socially and at work. 140 participants will either take part in these workshops or do non-specific writing sessions…

This study investigates how the brain processes social decisions like trust and cooperation. Participants play a modified trust game, either in an MRI scanner or online, where their choices affect monetary gains or losses. The goal is to link brain activity and behavior to person…

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biol…

This study looks for brain-based markers (biomarkers) of obsessive-compulsive disorder (OCD) in people with severe, hard-to-treat symptoms. Participants complete decision-making tasks and are exposed to personal OCD triggers while their brain activity is recorded with EEG and the…

This study tests whether transcranial magnetic stimulation (TMS), a noninvasive brain stimulation technique, can temporarily improve social cognition and brain function in 60 adults with high psychopathic traits. Participants will receive either real or sham TMS over three sessio…

This study looks at how emotional regulation varies across the menstrual cycle in autistic women. Researchers will compare them to women with borderline personality disorder, premenstrual dysphoric disorder, and those without any diagnosed condition. The goal is to better underst…

This study checks in with people who received mentalization-based treatment (MBT) for borderline personality disorder more than 10 years ago. Researchers want to see how they are functioning now, whether symptoms have changed, and if the type of MBT they received matters. Partici…

This study looks at how certain brain circuits cause strange sensory feelings in people with Obsessive-Compulsive Disorder (OCD). It will test if a non-invasive brain stimulation technique called rTMS can reduce these symptoms. The study involves 120 adults with OCD and healthy v…

This study looks at whether differences in how people see and hear can serve as early warning signs for psychosis. Researchers will compare young adults at high risk or with first-episode psychosis to healthy controls using visual and auditory tasks, plus retinal recordings. The …

This study uses EEG brain scans to understand how people with borderline personality disorder (BPD) process social rejection. Researchers will measure brain activity while participants play a virtual ball-tossing game designed to make them feel left out. The goal is to identify d…

This study will compare obsessive-compulsive symptoms in 102 adults with substance use disorder to a similar group without it. Participants will complete interviews and questionnaires to measure OCD severity, addiction severity, and quality of life. The goal is to understand how …