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Brain scans reveal why social rejection hurts more in BPD

NCT ID NCT07428200

Knowledge-focused Sponsor: Hôpital le Vinatier Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses EEG brain scans to understand how people with borderline personality disorder (BPD) process social rejection. Researchers will measure brain activity while participants play a virtual ball-tossing game designed to make them feel left out. The goal is to identify differences in the brain's pain network that may explain why social rejection feels more intense for those with BPD. Findings could lead to new ways to help reduce social pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 62 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For patients, a diagnosis of borderline personality disorder (established by a board-certified psychiatrist during a structured interview using the MINI) based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) * For healthy individuals, no psychiatric disorders according to the DSM-5 (except for tobacco use) * Must be between 18 and 40 years old * Must provide a signed, free, and informed consent form * To be affiliated with a social security scheme in France or to be a beneficiary of such a scheme Exclusion Criteria: * Known neurological disorders (patient group and control participants) * Comorbid psychiatric disorders (e.g., current depressive episode; ADHD treated with methylphenidate; bipolar disorder) * Active substance use disorder (excluding tobacco) * Pregnancy or breastfeeding * Guardianship * Consuming more than three alcoholic drinks in the past 24 hours * Consuming alcohol on the day of the experiment * Consuming tea or coffee less than one hour before the experiment

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Conditions

The condition(s) this trial relates to.

borderline personality disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Borderline personality disorder (BPD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre Hospitalier le Vinatier

    Bron, 69500, France

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