Laryngeal disorder

This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This study tests whether using the Provox ActiValve voice prosthesis as a first choice can reduce the number of times the device needs to be replaced each year in people who have had their voice box removed (laryngectomy) and have a tracheoesophageal puncture (TEP). The trial wil…

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This phase II trial tests a combination of two drugs—SYS6026 and Enlonstobart—in people with advanced solid tumors that have spread and are linked to HPV types 16 or 18. The study aims to see if the combination is safe and shows signs of shrinking tumors. Participants must be at …

This study tests if pirfenidone, a drug used for lung scarring, can safely slow scar buildup in the windpipe of people with idiopathic subglottic stenosis (iSGS). About 40 adults will receive either pirfenidone or a placebo for one year, alongside their usual steroid injections. …

This study tests a nerve-monitoring device that alerts surgeons when a child's vocal cord nerve is at risk during throat, chest, or heart surgery. About 90 children under 18 will be randomly assigned to standard care or standard care plus the monitor. After surgery, doctors will …

This study tests whether giving two drugs (vibecortamab and putilimab) before surgery can help shrink tumors in people with locally advanced laryngeal cancer. About 10 adults aged 18-80 with resectable cancer will receive the combination, then have surgery. The main goal is to se…

This phase 2 trial tests whether giving a combination of the immunotherapy drug camrelizumab and two chemotherapy drugs (paclitaxel and carboplatin) before surgery can improve outcomes for people with advanced oral cavity or larynx cancer. Fifty participants will receive three cy…

This study tests whether taking a short course of capecitabine pills before surgery can shrink tumors and improve outcomes for people with HPV-negative head and neck cancer. About 75 adults with stage III or IVa cancer will be randomly assigned to either standard care or capecita…

This study tests a shorter, higher-dose radiation schedule (3.5 Gy per fraction for 17 sessions) for people with early-stage glottic cancer (T1-T2N0M0). The goal is to see if this approach controls the tumor as well as standard longer radiation, while being more convenient. About…

This trial tests whether two imaging agents, Panitumumab-IRDye800 and [18F]NOTA-ABY-030, are safe and useful for helping surgeons identify head and neck tumors and cancer-containing lymph nodes during surgery. Adults with head and neck squamous cell carcinoma who are scheduled fo…

This study explores whether regular voice recordings can help predict disease severity in people with laryngotracheal stenosis, a condition that narrows the airway. Researchers will use artificial intelligence to analyze voice changes and see if they can forecast when a dilation …

This study looks at whether certain blood inflammation markers can help doctors tell the difference between harmless, precancerous, and cancerous vocal cord growths. Researchers will check medical records of 250 adults who have been diagnosed with a vocal cord lesion. The goal is…

This study will test artificial intelligence algorithms that analyze video from routine endoscopies of the head and neck. The AI will try to detect, classify (benign vs. malignant), and outline lesions, comparing its performance to doctors and lab results. About 283 adults with s…

This trial tests whether giving IV fluids on a fixed schedule during chemoradiation for head and neck cancer can reduce severe side effects like mouth sores, swallowing problems, and kidney injury. Half of the participants will receive IV fluids twice a week starting in week 3 of…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study tests a new adhesive baseplate for people who have had their voice box removed (laryngectomy). The adhesive helps secure a breathing tube and is used right after surgery. Researchers want to see if it is safe, comfortable, and gentle on the skin. Twenty-five adults wil…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve voice quality in people with laryngeal dystonia, a condition that causes involuntary muscle spasms in the voice box. Twenty adults with the c…

This study tests a new device that uses muscle signals from the face and neck to recognize silent speech and turn it into voice. It is for adults who have lost their voice due to laryngectomy or severe voice problems. The goal is to see if the device can accurately identify words…

This early study tests whether a long-acting form of sodium oxybate (Lumryz) can improve voice symptoms in 8 adults with spasmodic dysphonia or voice tremor. Participants will take the drug and have their voice and brain activity measured. The goal is to see if the drug works and…

This study tests whether two breathing exercise devices, EMST and Triflo, can reduce voice fatigue and improve voice quality in academics who teach a lot. Forty participants will use the devices for 5 weeks, and their voice measurements and fatigue scores will be tracked. The goa…

This study compares voice therapy delivered in-person versus via telehealth for adults aged 55 and older with age-related voice problems. Thirty participants will receive four sessions of PhoRTE® voice exercises either face-to-face or through video calls. Researchers will measure…

This pilot study will test whether using ultrasound during common office procedures for voice and swallowing problems is helpful and practical. Researchers will enroll 200 adults with conditions like chronic cough, vocal cord issues, or swallowing difficulties. They will measure …

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change before treatment and at 3, 6, and 12 months after. Researchers will use questionnaires to track these changes. The goal is to better understand recovery …

This study tests whether using a bedside ultrasound to guide throat suctioning can reduce lung infections and injuries in ICU patients on breathing machines. About 321 adults expected to need a breathing tube for at least 72 hours will take part. The goal is to see if this imagin…

This study looks at how removing the adenoids and tonsils changes children's voices and speech. Thirty-six children aged 4 to 13 will have their voices tested before surgery and again 1 and 3 months after. The goal is to help doctors better explain possible voice changes to famil…

This study tests a computer algorithm (EAP-LC) that uses CT scans to predict the best path for placing a breathing tube in laryngeal cancer patients. Researchers will compare the algorithm's predictions to actual tube placement videos from 70 patients. The goal is to see if the a…