Hypochromic microcytic anemia

This study tests whether a single intravenous dose of ferumoxytol raises hemoglobin more effectively than daily oral ferrous sulfate in pregnant women with iron deficiency anemia. Participants are between 24 and 34 weeks pregnant with a single baby. The trial measures hemoglobin …

This trial investigates whether anemic patients scheduled for hip or knee replacement surgery benefit from taking an iron supplement (Sideremil Vita) for 30 days before the operation, compared to taking it for only 15 days. The goal is to see if the longer treatment reduces the n…

This study tested whether giving oral iron every other day works as well as daily dosing for treating iron deficiency anemia in children up to 5 years old. Sixty children participated, and researchers measured changes in hemoglobin and ferritin levels. The goal was to find a simp…

This study tested whether an iron injection works better than iron pills for treating anemia in 200 new mothers within 10 days of giving birth. Participants had mild to moderate anemia and were randomly assigned to receive either a single injection of ferric carboxymaltose or ora…

This study tested whether adding a structured treadmill walking program to standard iron therapy improves exercise tolerance and quality of life in young women with mild-to-moderate iron deficiency anemia. Sixty women aged 18-28 were split into two groups: one received iron suppl…

This study looked at 1331 women aged 18-45 who had low iron stores but normal hemoglobin (no anemia). They were split into three groups: one got daily oral iron pills for 3 months, another got three IV iron infusions over 3 months, and a third got no treatment. The goal was to se…

This study tested whether a mineral-enriched powder taken daily for six months could raise blood iron levels in women aged 18-35 with iron deficiency. Participants mixed the powder or a placebo into water and provided blood samples monthly. The goal was to see if the powder reduc…

This study tested whether a peanut-based nutritional supplement could improve health in adults aged 60 and older living in peri-urban Ghana. Over 12 weeks, 81 participants either took the supplement daily or served as a control group. Researchers measured weight, blood pressure, …

This completed study looked at 128 adults with chronic kidney disease (not on dialysis) who also had iron-deficiency anemia. Researchers compared two intravenous iron treatments—ferric carboxymaltose and iron sucrose—to see which raises hemoglobin and iron levels better and with …

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This early-stage study tested whether adding a drug called BMS-986004 to standard immune-suppressing medicine could help prevent acute graft-versus-host disease (GVHD) in 45 adults with blood cancers or disorders receiving a stem cell transplant. GVHD occurs when donor immune cel…

This study tested whether a hydrochloric acid lock can help treat central line infections in 212 cancer and blood disease patients. The acid solution was placed in the line for 10 minutes, repeated three times, alongside standard antibiotics. The goal was to see if it reduces tre…

This study gave 223 children aged 12-18 months in India either iron- and zinc-biofortified pearl millet or regular pearl millet for 9 months. Researchers measured changes in iron levels, growth, and immune responses. The goal was to see if this enriched grain could help prevent c…

This completed Phase 1 trial tested whether a single IV dose of ferric carboxymaltose works better than daily oral polysaccharide iron complex capsules for treating iron deficiency anemia in pregnant women. 112 women in their second trimester with low hemoglobin levels took part.…

This study tested three types of iron supplements in 187 adults who had low iron before major surgery and developed anemia after it. The goal was to see which treatment—two different IV iron formulas or oral iron pills—worked best to quickly raise hemoglobin levels. The results h…

This study tested whether giving iron through a vein (IV) works better than iron pills for improving heart pumping function in people who recently had a heart attack and also have low iron. About 300 adults took part, receiving either IV iron or oral iron. The main goal was to se…

This study tested whether taking oral iron every second day at double the standard dose helps people with iron deficiency absorb more iron and raise their hemoglobin faster than taking it daily. 29 adults with low iron but not severe anemia participated for 12 weeks. Researchers …

This study looked at 50 patients who needed a stem cell transplant from a partially matched donor but had antibodies that could attack the donor cells. Before transplant, they received a blood purification treatment called protein A immunoadsorption to remove those antibodies, so…

This study tested a new iron supplement called ferric maltol (given as an oral suspension) against the standard ferrous sulfate liquid in children aged 2 to 17 with iron-deficiency anaemia, and also tested ferric maltol alone in infants aged 1 month to 2 years. The goal was to se…

This completed trial tested a single 15-minute infusion of ferumoxytol, a type of intravenous iron, in 60 people with iron deficiency anemia who couldn't take oral iron. The goal was to see if this quick dose safely raises hemoglobin levels. Researchers checked for side effects r…

This study looked at whether giving children with iron-deficiency anemia oral iron for 6 to 12 weeks before elective surgery can raise their hemoglobin levels. Researchers enrolled 755 children in South Africa to test this simple, low-cost approach. The goal is to see if treating…

This pilot study looked at whether taking an iron supplement called sucrosomial iron for three months can raise hemoglobin levels in blood donors who have iron deficiency. Fifty donors with low iron took the supplement daily. Researchers measured changes in hemoglobin, ferritin, …

This study tested whether taking a daily supplement of lactoferrin (a protein found in milk) can help prevent iron deficiency anemia in pregnant women with obesity. 23 women at risk for anemia took part from mid-pregnancy through labor. The main goal was to see if the approach wa…

This study tested whether giving intravenous iron to pregnant women who have low iron stores but not yet anemia can prevent them from becoming anemic and help their babies grow normally. 600 women took part. The goal is to see if a single IV dose works better than usual care.

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This study looked at whether a single intravenous iron dose could improve exercise capacity in people with severe aortic stenosis and iron deficiency who were scheduled for a valve replacement. About 100 participants received either iron or a placebo. The main goal was to see if …

This study tested a monthly online peer support group for young adults (ages 18-39) who had received a stem cell transplant. The group met for one hour over six months, led by a nurse and social worker. The goal was to see if the program was practical and helpful for reducing anx…

This study tested whether montelukast (Singulair), a common asthma drug, can reduce the number and severity of infusion reactions in people receiving monoclonal antibody treatments for blood disorders. Forty adults were given montelukast along with standard premedication before t…

This study looked at whether giving iron supplements to children with ADHD, restless legs syndrome, and low iron levels could improve their symptoms. Twelve kids aged 10-15 took iron for 3 months. Researchers measured changes in brain iron, blood iron, and symptoms using sleep mo…

This study examined the link between obesity and iron deficiency anemia in 165 nonpregnant Indonesian women aged 19-29. Participants took daily iron-folic acid supplements for 90 days. Researchers compared iron levels between overweight/obese and normal-weight women to see if wei…

This study looked for a virus called HHV6 in the skin and blood of 37 adults with blood cancers who developed a rash during hospital stays. The goal was to see if the virus is linked to the rash, which could help doctors diagnose and treat the rash more effectively. The study is …

This pilot study investigates how common low energy availability, iron deficiency, and low vitamin D levels are among Black collegiate athletes. Participants who are found to have low iron or vitamin D will receive daily supplements for 12 weeks. The goal is to better understand …

This study looked at how well iron-deficient women absorb iron from two plant-based sources—iron chlorophyllin and soy hemoglobin—compared to standard ferrous sulfate and animal-based heme iron. Forty-five women with low iron stores but not anemic took each type of iron in water …

This completed study looked at how well healthy pre-menopausal women with low iron stores absorb iron from two different supplements: Spatone (a natural iron-rich water) and ferrous sulphate (a standard iron pill). Fourteen women took three different doses (5, 10, and 15 mg) of e…

This study looked at whether it is safe to lower the number of platelets needed before placing a central line (a special IV) in patients with blood disorders. Normally, patients get a platelet transfusion if their count is below 50, but this study tested a lower trigger of 10. Th…

This study looked at how weight loss from a calorie-restricted diet affects iron levels in people with obesity and iron deficiency. Researchers measured a protein called hepcidin, which controls iron in the body, along with iron levels before and after a 60-day diet. The goal was…

This study looked at why many older adults (over 70) have anemia even when doctors can't find a reason. Researchers measured how long red blood cells live in younger and older adults by marking them with a vitamin called Biotin. The goal was to understand if faster red blood cell…

This study explored whether low hemoglobin (anemia) is linked to an enlarged heart (cardiomegaly) in children up to 18 years old. Researchers used chest X-rays and echocardiograms to check for heart enlargement in 56 anemic children. The goal was to better understand how anemia a…

This study looked at how well pregnant women with iron deficiency anemia tolerate and stick with oral iron therapy. Researchers tracked side effects and checked if iron levels improved using blood tests. The goal was to better understand how to treat this common condition during …

This completed study looked at 830 two-year-olds in France to see if drinking toddler milk formula helps prevent iron deficiency, a common problem that can affect brain development. Researchers checked iron levels in blood and asked parents about diet and background. The goal is …

This study gathered information from 250 children aged 6 months to 6 years to develop artificial intelligence that can estimate iron levels from images and videos. The goal is to create a non-invasive way to screen for iron deficiency, replacing blood tests. Parents and doctors a…

This completed study tested whether artificial intelligence and MRI scans could help automate the planning of total marrow irradiation, a type of radiation therapy given before a bone marrow transplant for blood cancers. Researchers aimed to reduce the 10-day planning time and be…

This study looked at whether giving oral iron supplements to iron-deficient women in Kenya before or at the same time as vaccination improves their immune response. 180 women received iron either before or with three vaccines (COVID-19, meningitis, and typhoid), or a placebo. The…

This study looked at over 1,200 people in Denmark who had a stem cell transplant for blood diseases, some as far back as 1970. Researchers used detailed surveys to measure late effects and quality of life. The goal is to find out what medical and personal factors help survivors f…

This study looked at how many women with fibromyalgia at a pain clinic might have iron deficiency. 81 women completed a questionnaire about symptoms like heavy periods and past iron issues. The goal was to see if iron deficiency is common and if treating it could help their pain.

This completed study examined lung CT scans from 148 adults with blood diseases to identify common patterns of lung involvement. Researchers tracked how often certain radiological features appeared and counted complications. The goal was to better understand the range of lung iss…

This completed study looked at how often a rare blood condition called methemoglobinemia occurs after treatment with the IV iron drug ferric carboxymaltose. Researchers measured methemoglobin levels in nearly 1,000 adults receiving the drug for iron-deficiency anemia and compared…

This study looked at whether iron deficiency anemia makes COVID-19 vaccines less effective in young women. Researchers gave intravenous iron to 121 participants and measured their immune responses. The goal was to see if correcting iron deficiency could boost vaccine protection.