Esophagitis

This study tests an experimental drug called X842 in people with severe erosive esophagitis caused by GERD (chronic acid reflux). Participants have either severe esophagus damage (grades C or D) or milder damage that hasn't healed after 8 weeks of standard treatment. The trial co…

This study tested a new drug called BLI5100 in 1250 adults with erosive esophagitis, a condition where stomach acid damages the esophagus. Participants took either BLI5100 or a standard PPI (proton pump inhibitor) daily for up to 8 weeks to see if it healed the damage, then for 2…

This phase 2 trial tested a biologic drug called barzolvolimab in 86 adults with active eosinophilic esophagitis, a condition that causes trouble swallowing due to inflammation in the esophagus. Participants received either the drug or a placebo as a shot under the skin. The stud…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested whether a personalized diet, based on a blood test that identifies food allergies, can help people with eosinophilic esophagitis (EoE). 56 participants were randomly assigned to either a personalized elimination diet or a sham diet. The goal was to see if the pe…

This study looks at the long-term safety of a drug called CC-93538 (cendakimab) for people with eosinophilic esophagitis, a condition that causes inflammation in the esophagus. It enrolled 367 adults and teens who had already taken part in earlier studies of the same drug. The ma…

This study compared two types of gastric bypass surgery for obesity to see which one leads to fewer problems like acid reflux and stomach ulcers. Two hundred adults with a BMI between 30 and 50 took part. The goal was to find out which surgical method is safer and more effective …

This completed Phase 3 study tested the drug D961H (esomeprazole) in 50 Japanese children to see if it can prevent reflux esophagitis from coming back and stop stomach or duodenal ulcers from recurring in kids taking NSAIDs or low-dose aspirin. Children took the drug for up to 52…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study tested whether the drug dupilumab can help children and young adults (ages 6 to 25) with eosinophilic esophagitis (EoE) safely reintroduce foods that normally trigger their symptoms. EoE is a condition where certain foods cause inflammation in the esophagus, and curren…

This study tested dupilumab (Dupixent) in 102 children with active eosinophilic esophagitis, a condition where white blood cells build up in the esophagus, causing pain and swallowing problems. The drug aims to reduce inflammation and improve tissue health. Results will show if d…

This study checked the safety of taking BLI5100 daily for up to 12 months in 400 adults with gastroesophageal reflux disease (GERD). Participants had either non-erosive reflux disease or healed erosive esophagitis. The main goal was to track any side effects. This is a disease co…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested two radioactive imaging agents, NDX-3315 and NDX-3324, to see if they can safely and accurately detect eosinophilic esophagitis (EoE), a condition where immune cells build up in the esophagus. It involved 34 people—some healthy and some with EoE. The goal was to…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedet…

This pilot study tested whether people with eosinophilic esophagitis (EoE) triggered by milk can safely eat baked milk. Seven participants ate a baked milk muffin daily for six weeks. Researchers measured if this led to fewer eosinophils (a type of white blood cell) in the esopha…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study enrolled 800 adults undergoing upper endoscopy to find risk factors and blood markers that could help diagnose and monitor eosinophilic esophagitis (EoE), a chronic allergic condition of the esophagus. Researchers compared people with and without EoE, collecting blood,…

This early-phase trial tested the safety and tolerability of a drug called X842 in 39 healthy adults. Participants received either single or multiple doses of X842 to see how the body handles it and what side effects may occur. The study is complete and does not aim to treat any …

This early-stage study tested two different forms of the experimental drug AQ280 in 9 healthy adults. The goal was to see how well the body absorbs the drug when given as a capsule versus a tablet that dissolves in water. The results will help researchers decide which form to use…

This completed study looked at 100,000 patient records to find out if people with eosinophilic esophagitis (EoE) are more likely to develop esophageal cancer. The researchers wanted to see if any increased risk is due to EoE itself or to other conditions like acid reflux or Barre…

This study looked at specific immune cells in the esophagus of children with eosinophilic esophagitis (EoE) compared to healthy children. Researchers counted these cells and also studied the microbiome. The goal was to better understand the disease, not to test a treatment. 35 ch…

This study compared a generic vonoprazan 20 mg tablet to the brand-name Voquezna in 28 healthy adults. Participants took a single dose of each under fasting conditions to see if the generic releases the same amount of drug into the bloodstream. The goal was to check bioequivalenc…

This study looked at whether detergents found in common products like toothpaste can make the lining of the esophagus leaky and cause allergic inflammation, which is a key feature of eosinophilic esophagitis. Researchers tested 12 healthy volunteers by measuring changes in the es…