Esophagitis

This study tests whether upadacitinib, a drug already used for other conditions, can help adults with eosinophilic esophagitis (EoE) who still have symptoms despite using topical steroids. Over 12 weeks, 52 participants will take either upadacitinib or a placebo, then all will re…

This study compares two versions of a minimally invasive procedure called POEM for treating achalasia, a swallowing disorder. The standard POEM often causes severe heartburn afterward. The new version, Sling-Fiber Preserving POEM, aims to reduce that risk by leaving certain stoma…

This study tests a new blood test that aims to identify which foods are triggering Eosinophilic Esophagitis (EoE) in children. About 50 kids with EoE will follow a diet based on the test results, and doctors will check if the test accurately predicts food allergies compared to st…

This study tests whether a product made from spirulina (a type of algae) can prevent severe throat pain caused by radiation therapy in people with esophageal cancer. About 70 patients will receive either the spirulina derivative or a placebo during their radiation treatments. The…

This pilot study compares recorded gut-directed hypnosis to an educational recording for hospitalized patients with chronic gut problems, such as irritable bowel syndrome or inflammatory bowel disease. Participants listen to the recordings over the phone while in the hospital for…

This study tests whether daily red light therapy can prevent or reduce skin and mouth side effects in children aged 0-16 receiving radiation for cancer. About 248 kids will get a daily LED light treatment on the radiated area. Researchers will compare their side effects to those …

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…