Dental pulp necrosis

This study compares two ways of making dental crowns for back teeth that have had root canals: 3D-printing from a ceramic-filled resin versus milling from a ceramic block. Sixty adults will receive one of these crowns and be checked for fractures, fit, and color over two years. T…

This study tests whether a robot can place dental implants more accurately than a computer-guided navigation system in the front upper jaw. Twenty-four adults needing an implant will be randomly assigned to one of the two methods. The main goal is to see which approach achieves b…

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This study tests whether an antibiotic paste (LSTR) works as well as the standard filling (ZOE) for treating infected baby molars in children aged 4 to 10. 180 kids will be randomly assigned to one treatment and checked after 6 months for healing. The goal is to find a simpler, e…

This study tests whether graphene oxide can successfully treat decayed baby teeth that need pulp therapy. 126 children will be split into groups receiving graphene oxide, standard materials like MTA or zinc oxide, or a lesion sterilization technique. The goal is to see which appr…

This study tests whether heating sodium hypochlorite (a common disinfectant) inside root canals of dead teeth can kill more bacteria and reduce pain afterward. Thirty-six adults with a single dead tooth will receive one of two heating methods or standard cleaning. Researchers wil…

This study compares two dental procedures for treating infected baby molars in children aged 4 to 8. One method removes only the infected part of the tooth's nerve (pulpotomy), while the other removes the entire nerve (pulpectomy). The goal is to see if the simpler pulpotomy work…

This study tests whether natural substances like grape seed extract and glycyrrhizin can replace antibiotics in a procedure to revive dead permanent teeth in children aged 7-13. The goal is to restore blood flow and promote root growth while reducing pain and infection. The trial…

This study tests whether a gel made from a patient's own blood (platelet-rich fibrin) can help regenerate the inner part of infected or dead teeth in adults. 57 participants will receive either the gel or a standard blood-clot treatment. The goal is to see if the gel reduces infe…

This study will compare three methods for testing whether a tooth's nerve is alive (vital) or dead (nonvital): laser Doppler flowmetry, cold testing, and electric pulp testing. About 150 people who need root canal treatment will receive all three tests before treatment. The goal …

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study compares two strengths of sodium hypochlorite (a disinfectant used during root canals) to see which causes less pain afterward. 116 adults needing a root canal will be randomly assigned to receive either a 2.5% or 5.25% solution. Pain levels will be measured at 6, 12, …

This study tests whether a new type of root canal filling material (bioceramic nano-coated gutta-percha with a bioceramic sealer) causes less pain and swelling after treatment compared to the standard material (gutta-percha with a resin sealer). About 30 adults aged 20-55 with a …

This study tests four different ways to clean infected root canals to see which one reduces bacteria and pain the most. Forty adults with tooth infections will be randomly assigned to one of the cleaning methods. The goal is to find a better way to disinfect teeth while making th…

This study compares a 1% melatonin gel to a standard calcium hydroxide paste placed inside the tooth after root canal cleaning. It aims to see which one better reduces pain, lowers bacteria, and affects a certain protein linked to healing. The trial will involve 50 adults with a …

This study tests a new rinse called Triton during root canal treatment for dead teeth. It aims to see if it kills more bacteria and causes less pain afterward than the standard rinse. Thirty-six adults with infected lower molars will take part. The results could help dentists cho…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study compares two different medicines placed inside a tooth during a root canal to see which one is better at killing bacteria and reducing pain afterward. About 52 adults with infected single-root teeth will take part. The goal is to find which treatment leads to less disc…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study compares two ways to clean a tooth's root canal (step-back vs step-down) to see which one leads to less pain afterward. About 110 adults with a dead nerve in a single-root tooth will be randomly assigned to one method. Pain levels will be tracked for a week using a sim…

This study will test if a technique called 'apical patency'—gently passing a small file just past the root tip during cleaning—can reduce pain after a root canal. 48 adults with a dead nerve and infection in a back molar will be randomly assigned to receive either this technique …

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study follows 70 adults aged 20-60 who need root canal treatment on a premolar or molar. Researchers measure how hard they can bite and how force spreads across teeth before treatment, after root canal, after a crown, and up to 4 years later. They also ask about chewing comf…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…