Dental pulp necrosis
MONDO:0001326Death of pulp tissue with or without bacterial invasion. When the necrosis is due to ischemia with superimposed bacterial infection, it is referred to as pulp gangrene. When the necrosis is non-bacterial in origin, it is called pulp mummification.
Also known as: necrosis of pulp, necrosis of the pulp, necrotic pulp, pulp necrosis
88 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Light-Activated therapy boosts root canal disinfection?
Disease control CompletedThis study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…
Phase: NA • Sponsor: Bayan Alqrenawi • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Can dead teeth be brought back to life? new study tests regeneration vs. standard cleaning
Disease control CompletedThis study compared three approaches for treating dead, infected adult teeth: a regenerative procedure that induces bleeding inside the tooth, standard cleaning and sealing, and a combination. Fifty-four adults with an infected upper premolar were treated and followed for healing…
Phase: NA • Sponsor: Ain Shams University • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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New antibiotic paste could replace drilling for Kids' cavities
Disease control CompletedThis study tested a new, less invasive way to treat infected baby molars in children aged 4 to 10. Instead of fully cleaning out the tooth canals (standard pulpectomy), the new method uses an antibiotic paste to kill infection without drilling. The study involved 110 children and…
Phase: NA • Sponsor: taymour abuawwad • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Dental showdown: which crown works best for Root-Canal teeth?
Disease control CompletedThis study tested two types of ceramic dental restorations for teeth that have had root canal treatment: overlays and endocrowns. Twenty-five patients received one of the two restorations, and researchers checked how well they fit, any color changes at the edges, and how satisfie…
Phase: NA • Sponsor: Cairo University • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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New Tooth-Saving method could help kids avoid root canal failure
Disease control CompletedThis study tested a new way to treat children aged 6 to 18 who have a dead nerve in an immature tooth. The new method uses a material called MTA to help the tooth form a hard barrier, compared to the standard treatment with calcium hydroxide. The goal was to see which method work…
Phase: PHASE3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 09:11 UTC
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New filling material saves baby teeth that have no permanent replacement
Disease control CompletedThis study looked at using a special filling material called OrthoMTA for root canals in second baby molars that have no permanent tooth growing underneath. Thirteen children received the treatment and were checked for up to 12 months to see if the tooth stayed healthy and infect…
Phase: NA • Sponsor: Tokat Gaziosmanpasa University • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Dead tooth brought back to life? new pilot study shows promise
Disease control CompletedThis small pilot study tested a new way to treat dead (necrotic) teeth in 6 adults. Doctors took pulp tissue from a healthy donor tooth, mixed it with a growth factor concentrate (CGF), and transplanted it into the dead tooth. After 12 months, they checked if the tooth regained f…
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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New dental technique helps regrow roots in young teeth
Disease control CompletedThis study tested three different materials (blood clot, platelet-rich fibrin, and concentrated growth factor) combined with two types of rinses to help regrow root tissue in 30 immature permanent teeth with dead nerves. Participants aged 9 to 25 were followed for 12 months using…
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Dead teeth revived with pulp transplant in small trial
Disease control CompletedThis study tested whether transplanting pulp tissue from a healthy tooth into a dead one could restore vitality. Twenty-one adults with dead single-rooted teeth received either a pulp transplant, a pulp transplant with growth factors, or standard root canal treatment. The goal wa…
Phase: NA • Sponsor: Kahramanmaras Sutcu Imam University • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Dentists put cold, heat, and electric tooth tests to the test
Diagnosis CompletedThis study tested how well cold, heat, and electric pulp tests detect tooth nerve health in 175 adults needing root canals. Researchers compared test results to direct observation of nerve bleeding during treatment. The goal was to find which test is most accurate for diagnosing …
Sponsor: Istanbul University • Aim: Diagnosis
Last updated Jun 27, 2026 09:09 UTC
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New scale could help predict fall risk for hospital patients in turkey
Diagnosis CompletedThis study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Lasers vs. needles: which root canal hurts less?
Symptom relief CompletedThis study tested whether using special lasers during root canal treatment can lower pain afterward compared to standard methods. Forty-five adults with infected front teeth were split into three groups: one got standard cleaning, another got a combination of two lasers, and the …
Phase: PHASE2 • Sponsor: Future University in Egypt • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Root canal relief: study tests which fillings hurt less
Symptom relief CompletedThis study looked at 120 people who needed root canal treatment on their molars. Researchers tested different filling materials (bioceramic vs. resin-based) and techniques (cold vs. warm filling) to see which caused the least pain afterward. The goal is to help dentists choose op…
Phase: NA • Sponsor: Jordan University of Science and Technology • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Physiotherapy students test muscle relief techniques on themselves
Symptom relief CompletedThis study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Who should control your sedation during surgery? new study compares options
Symptom relief CompletedThis study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…
Phase: NA • Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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New turkish health survey could improve care for muscle and joint problems
Knowledge-focused CompletedThis study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…
Sponsor: Istanbul Bilgi University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Laser vs ultrasound: which cleans root canals better?
Knowledge-focused CompletedThis small study tested two methods for cleaning infected root canals: ultrasonic activation and a 980-nm diode laser. Sixteen adults with dead (necrotic) teeth had their root canals cleaned with one of these methods. Researchers checked for leftover bacterial DNA to see which me…
Phase: NA • Sponsor: Hasanuddin University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Physios take on ER duty: study tests if they can replace doctors for back pain
Knowledge-focused CompletedThis study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…
Phase: NA • Sponsor: Bern University of Applied Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Root canal study tracks immune signals in tooth fluids
Knowledge-focused CompletedThis completed study measured two immune proteins, IL-8 and IL-10, in fluid from the gums and around the tooth root during root canal treatment. Researchers wanted to see how these levels change as treatment progresses in people with infected, dead tooth pulp. Twenty-two adults a…
Phase: NA • Sponsor: Faculty of Dental Medicine for Girls • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Can CRPS patients imagine movement? new study investigates
Knowledge-focused CompletedThis completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Mind, spirit, and pain: new study explores what chronic pain patients really believe
Knowledge-focused CompletedThis study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC