Dental pulp necrosis
MONDO:0001326Death of pulp tissue with or without bacterial invasion. When the necrosis is due to ischemia with superimposed bacterial infection, it is referred to as pulp gangrene. When the necrosis is non-bacterial in origin, it is called pulp mummification.
Also known as: necrosis of pulp, necrosis of the pulp, necrotic pulp, pulp necrosis
61 clinical trials for this condition and its sub-types.
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Could a cholesterol drug save infected baby teeth?
Disease control Recruiting nowThis study compares two treatments for infected baby molars in children aged 5 to 8. One group gets a standard antibiotic paste, the other gets simvastatin (a common cholesterol drug). Both are placed inside the tooth after cleaning, and the tooth is sealed. Researchers will chec…
Phase: PHASE2 • Sponsor: Dow University of Health Sciences • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Could a tooth-based gel save kids' teeth? new trial explores regenerative dental treatment
Disease control Recruiting nowThis study tests whether two forms of demineralized dentin matrix (a material made from tooth tissue) can help regenerate immature permanent teeth in children aged 9 to 15. The trial compares these materials to a standard sealing material called RetroMTA. Over 12 months, research…
Phase: NA • Sponsor: Kafrelsheikh University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New study tests which irrigation system best cleans infected root canals
Disease control Recruiting nowThis study compares two irrigation systems, GentleWave and EdgePro, for cleaning infected root canals in teeth with dead nerves. Researchers will measure how much bacteria is reduced after treatment. 30 adults with permanent teeth needing root canal treatment will participate.
Phase: NA • Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated Jun 26, 2026 13:48 UTC
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Which root canal filling eases pain best? new study tests three options
Symptom relief Recruiting nowThis study tests whether placing ibuprofen, nitrofurantoin, or calcium hydroxide inside a tooth after root canal treatment can lower pain. About 111 adults with dead nerves in their back teeth will rate their pain on a 0-10 scale. The goal is to find which medication works best t…
Phase: EARLY_PHASE1 • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jul 23, 2026 00:00 UTC
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Which root canal filling hurts less? new study aims to find out
Symptom relief Recruiting nowThis study compares two common root canal filling techniques—cold lateral condensation and warm vertical obturation—to see which causes less pain afterward. About 80 adults with infected but pain-free teeth will be randomly assigned to one method. Researchers will measure pain le…
Phase: NA • Sponsor: University of Jordan • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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Laser-Ultrasonic duo takes on tooth pain
Symptom relief Recruiting nowThis study tests whether using a special laser along with standard ultrasonic cleaning can reduce pain and kill more bacteria after a root canal. About 120 adults with infected single-root teeth will be treated and asked to rate their pain. The goal is to find a better way to man…
Phase: NA • Sponsor: Al-Azhar University • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC
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Why do french dentists pull baby teeth? a new survey aims to find out
Knowledge-focused Recruiting nowThis study surveys 100 French dentists who treat children to understand why they often choose extraction for non-vital baby teeth, even though effective alternatives like pulpectomy exist. The goal is to collect and analyze their treatment choices, reservations, and decision-maki…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Which root canal device kills more bacteria? new study aims to find out
Knowledge-focused Recruiting nowThis study tests three different devices used during root canal treatment to see which one removes the most bacteria from infected teeth. Ninety adults with dead nerves in their premolars will be randomly assigned to one of the three methods. Researchers will measure bacterial le…
Phase: NA • Sponsor: Abhishek Parolia • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:40 UTC