Coronavinae infectious disease

This early-stage trial tested a new COVID-19 booster vaccine, STX-S, in 60 healthy adults who had already received a primary vaccine series and at least one booster. The vaccine uses tiny particles called exosomes to deliver spike proteins. The main goal was to check safety and s…

This study tested an experimental vaccine called VBI-2901a in 103 healthy adults aged 18-64 who had already received at least two doses of a licensed COVID-19 vaccine. The vaccine is designed to protect against three coronaviruses: SARS-CoV-2 (which causes COVID-19), SARS-CoV-1, …

This study tested updated versions of the Pfizer-BioNTech COVID-19 vaccine designed to target newer Omicron variants (XBB.1.5, JN.1, and KP.2). Over 1,000 healthy people aged 12 and older received a single dose. The main goals were to check safety and measure the immune response.…

This study tested whether three different manufacturing batches (lots) of Novavax's COVID-19 vaccine produce the same immune response and safety in adults. About 900 healthy adults aged 18 to 49 who had already been vaccinated received one of the three lots. The results help ensu…

This large study tested the safety and effectiveness of the Pfizer-BioNTech mRNA vaccine (BNT162b2) against COVID-19 in nearly 47,000 healthy volunteers aged 12 and older. Participants received two doses of the vaccine or a placebo, and the trial also explored booster doses and p…

This Phase 2 trial tested the BNT162b2 mRNA vaccine in 960 healthy Chinese adults aged 18 to 85. Participants received two doses of either the vaccine or a placebo, 21 days apart. The main goal was to check safety and measure the immune response, specifically neutralizing antibod…

This study tested the CoviVac COVID-19 vaccine in 200 healthy adults aged 60 and older. Researchers checked how safe the vaccine was and how well it boosted the immune system. The goal was to see if the vaccine could help prevent COVID-19 in this age group.

This study tested the safety and immune response of several Moderna mRNA vaccines for COVID-19, seasonal flu, RSV, and CMV in 308 healthy adults aged 18 to 75. Researchers monitored side effects and measured antibody levels after vaccination. The goal was to ensure the vaccines a…

This Phase 2 trial tested a new DNA vaccine called INO-4700 in 192 healthy adults to see if it is safe and can trigger an immune response against MERS, a serious coronavirus. The vaccine is given as a shot under the skin followed by a quick electric pulse to help cells take up th…

This early-stage trial tested several experimental mRNA vaccines that aim to protect against both influenza and SARS-CoV-2 in a single injection. About 1,758 healthy adults aged 18 to under 80 took part. The main goals were to check safety and measure the immune response, with re…

This large Phase 3 trial tested whether giving healthy people who already received the Pfizer-BioNTech COVID-19 vaccine one or more extra doses (boosters) is safe and effective. Over 16,000 participants in several countries received either the original vaccine, a version adapted …

This study tested three new self-amplifying RNA vaccines against COVID-19 in 72 healthy adults, some already vaccinated and some not. The goal was to check safety and how well the vaccines boost the immune system. Results help decide which vaccine candidates to study further.

This study tested a new COVID-19 vaccine called SpikoGen in 39 adults who had never received a COVID-19 vaccine. Participants received two doses one month apart, followed by a third booster dose either one or three months later. The goal was to see how well the vaccine triggered …

This study tested a new COVID-19 booster vaccine called SpiN-Tec in 432 healthy adults aged 18 to 85 who had already received full vaccination and at least one booster. The vaccine was compared to approved boosters like Covishield and Comirnaty. The goal was to check safety and w…

This completed Moderna trial tested the mRNA-1273 COVID-19 vaccine in over 4,300 healthy adolescents aged 12 to 17. The study looked at safety, side effects, and how well the vaccine works to prevent COVID-19. Participants received either the vaccine or a placebo, and some later …

This large study tested the Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19) in over 10,000 healthy UK adults aged 18 and older. The goal was to see if the vaccine safely prevents symptomatic COVID-19. Participants received either the vaccine or a control shot, and researche…

This study tested a new COVID-19 vaccine called ChAdOx1 nCoV-19 in over 1,000 healthy adults aged 18-55 in the UK. The goal was to see if the vaccine is safe, triggers an immune response, and can prevent COVID-19. Participants received either the vaccine or a comparison shot, and…

This study tests an experimental drug called SPI-1005 (ebselen) in adults hospitalized with severe COVID-19. Participants receive either the drug or a placebo to see if the drug is safe and helps improve recovery. The trial is randomized and double-blind, meaning neither patients…

This trial investigates whether famotidine, the active ingredient in Pepcid, can help relieve COVID-19 symptoms in adults who are not sick enough to be hospitalized. Participants receive either famotidine or a placebo, along with standard care, and report their symptoms remotely.…

This study looked at whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help critically ill patients fight the virus. The plan was to collect plasma from up to 240 recovered donors and give it to sick patients. However, the plasma donat…

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This study tested whether giving early treatment to adults with COVID-19 who have risk factors (like age over 60 or high blood pressure) could prevent them from needing oxygen, hospitalization, or dying. About 412 people took part. The goal was to see if these treatments are safe…

This early-stage trial tested the safety and tolerability of a new drug called PA-001 in 47 healthy and elderly volunteers. Participants received either PA-001 or a placebo through an IV. The main goal was to see if the drug causes any side effects and to understand how the body …

This study tested a drug called Auxora in 314 people with severe COVID-19 pneumonia. The goal was to see if it could help patients recover faster and reduce the need for breathing machines. Participants received either Auxora or a placebo, along with standard treatments. Results …

This study tested whether breathing in nitric oxide gas can improve oxygen levels in severely ill COVID-19 patients who are on ventilators. Researchers enrolled 200 adults in the ICU with confirmed COVID-19 and severe breathing problems. Patients received either standard care plu…

This study tested whether a single dose of stem cells (mesenchymal stromal cells) could help patients with severe COVID-19 lung inflammation breathe better. Twenty adults with confirmed COVID-19 and acute respiratory distress syndrome were randomly assigned to receive either the …

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe. 185 patients were randomly assigned to receive one of the drugs or standa…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This early-stage study tested a new drug called SIR1-365 in 45 hospitalized adults with severe COVID-19. The main goal was to see if the drug is safe and tolerable. Researchers also looked at whether it could reduce inflammation and improve patient outcomes. The trial was complet…

This study tested two drugs—remdesivir and aviptadil—in hospitalized COVID-19 patients with severe breathing failure. About 473 participants received either a study drug plus standard care or a placebo plus standard care. The goal was to see if these drugs could safely improve ou…

This completed Phase 3 trial tested the safety and effectiveness of remdesivir in 87 hospitalized COVID-19 patients with acute respiratory distress syndrome (severe breathing failure). Participants received either remdesivir plus standard care or a placebo plus standard care for …

This phase 3 trial tested whether the drug aviptadil can help hospitalized COVID-19 patients with acute respiratory distress syndrome (ARDS). 471 participants received either aviptadil plus standard care or a placebo plus standard care. The main goal was to see how well patients …

This phase 3 study tested the drug sarilumab (Kevzara®) in 420 adults hospitalized with severe or critical COVID-19. Participants received either sarilumab or a placebo by IV. The main goal was to see if sarilumab speeds up clinical improvement. The trial also tracked survival, n…

This early-stage trial tested an oral drug called SAR443122 in 68 hospitalized adults with severe COVID-19. The goal was to see if the drug could safely reduce harmful inflammation, measured by a blood marker called CRP. Participants were randomly assigned to receive the drug or …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This large Phase 3 trial compared a new experimental mRNA COVID-19 vaccine (mRNA-1283) with Moderna's original vaccine (mRNA-1273) in over 13,500 people aged 12 and older. The goal was to see if the new vaccine is safer, triggers a better immune response, and prevents COVID-19 at…

This study tested whether five infusions of stem cells from donated fat tissue could help prevent COVID-19 symptoms and hospital stays in people at high risk of exposure, like healthcare workers and first responders. The trial enrolled 53 participants who had no signs of COVID-19…

This study tested whether five infusions of a person's own stem cells (HB-adMSCs) could prevent COVID-19 symptoms and hospitalization in 51 high-risk adults, such as those over 65 or with underlying health conditions. Participants had previously banked their cells at Hope Bioscie…

This large study tested whether high-dose vitamin D3 supplements could help people recently diagnosed with COVID-19 avoid severe illness and also prevent the virus from spreading to their household members. Over 2,000 participants across the U.S. and Mongolia took either vitamin …

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This study tested a 30-week walking program for cancer survivors who had been hospitalized with COVID-19. The goal was to see if the exercise was safe and caused few side effects. Only 3 people took part, so the results are very early and not conclusive.

This study followed 324 people who had close contact with a confirmed COVID-19 case to see how long they shed the virus. Participants provided nasal swabs and reported symptoms over 12 days. The goal was to understand transmission risks and help shape public health policies.

This completed study followed 829 people, including healthcare workers and a comparison group, over several years to understand how SARS-CoV-2 spreads and who gets sicker. Researchers collected swabs, blood, and saliva samples along with survey data. The goal was to identify risk…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress over two years. The goal was to u…

This study looked at how well CPAP therapy works for COVID-19 patients who have trouble breathing. Researchers collected data from 250 patients in a hospital to see how they responded to treatment. The goal was to learn more about managing severe COVID-19 in real-life settings.

This study looked at children and young adults under 24 who had COVID-19, including those with cancer. Researchers collected samples and medical information to learn about symptoms, risk factors, and how the virus spreads. The goal was to better understand the disease in younger …

This completed study from the National Institute of Mental Health surveyed over 3,600 English-speaking adults online every two weeks for six months. Researchers asked about mental health symptoms, stress, and behaviors during the COVID-19 pandemic. The goal was to understand how …

This study looked at whether it is safe to give another dose of a COVID-19 mRNA vaccine to people who had a bad reaction to a previous dose, or to people with a history of allergies. It also included people with long COVID. A total of 137 adults took part and received either the …

This study tested whether a blood sample can predict how severe COVID-19 will become in kidney transplant patients with mild to moderate symptoms. Researchers measured a protein called IL-6 after stimulating the blood sample. They followed 52 patients to see if IL-6 levels were l…

This study looked at nearly 2,000 adults with lung cancer who caught COVID-19. Researchers tracked their health and checked for antibodies (immune system markers) right after infection and again 6 months after vaccination. The goal was to understand how lung cancer affects the bo…

This study looked at whether the COVID-19 virus can be found in the saliva of people who have no symptoms or only mild symptoms. Researchers collected samples from the nose, mouth, eyes, and blood, and also tested how many virus particles are released during speaking with and wit…

This study looked at how T-cells, a key part of the immune system, respond to the COVID-19 virus in 51 people—hospitalized patients and healthy hospital staff. Researchers measured T-cell activity at several time points using a blood test called ELISPOT. The goal was to better un…

This completed study from France enrolled 373 people who came to the emergency room with suspected COVID-19. Researchers checked routine blood markers to see if any could predict which patients would later get worse and need intensive care. The goal was to find simple, low-risk t…

This completed registry study collected data from 500 COVID-19 patients to learn how the virus affects kidney function. Researchers aimed to identify risk factors and track outcomes. The findings may help guide future treatment and care for kidney complications in COVID-19.

This completed study observed 199 adults hospitalized with confirmed COVID-19. Researchers tracked patient characteristics, treatments used, and how the disease progressed over time. The goal was to answer important questions about the natural history of COVID-19 to help guide fu…

This completed early-phase study looked at how mRNA COVID-19 vaccines (Pfizer or Moderna) affect certain immune cells called monocytes in people of different ages. Researchers measured changes in reactive oxygen species (a type of cell activity) and a blood protein called AngII b…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked back at how French hospitals created more intensive care unit (ICU) beds and found extra healthcare workers during the COVID-19 pandemic. Researchers gathered information from nearly 10,000 hospitals across France. The goal was to understand where the new beds c…

This study followed over 1,000 adults with confirmed or suspected COVID-19 who were admitted to intensive care units (ICUs) across France. Researchers tracked their treatments, complications, and survival at 28 days. The goal was to learn how these patients are managed and what f…

This study looked at 13 adults who had COVID-19 and still had symptoms like memory or nerve problems after recovery. Researchers used brain scans, memory tests, smell tests, and other exams to find possible changes in the nervous system. The goal was to better understand how COVI…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their mobility and daily function changed over time. Researchers measured physical abilities like walking, balance, and thinking skills. The goal is to understand recovery patterns so doctors can …

This study looked at why some COVID-19 patients lose their sense of smell. Researchers compared nasal cell samples from 26 people—some with COVID-19 and smell loss, and some healthy controls. They aimed to find molecular and cellular differences in the nose that might explain the…

This study tested whether sharing local wastewater COVID-19 data on social media could encourage more people to get vaccinated. Researchers selected 40 counties in New York, with 20 receiving the campaign and 20 serving as controls. The goal was to see if real-time, local informa…

This study followed 153 people with cancer who had or were suspected of having COVID-19. Researchers collected throat swabs and saliva samples over several weeks to see how well antibody and antigen tests work in this group. The goal was to learn more about the course of COVID-19…