Moderna vaccine shows promise for teens in large trial
NCT ID NCT04649151
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Moderna trial tested the mRNA-1273 COVID-19 vaccine in over 4,300 healthy adolescents aged 12 to 17. The study looked at safety, side effects, and how well the vaccine works to prevent COVID-19. Participants received either the vaccine or a placebo, and some later got a booster dose targeting the Omicron variant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mRNA-1273 (COVID-19 vaccine)
What this could lead to
If successful, this could show that the Moderna COVID-19 vaccine is safe and effective for adolescents, helping protect them from COVID-19.
What could go wrong
This trial is completed, but results may not apply to newer variants or other populations. Side effects like injection site pain and fever were monitored.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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ACRC Trials
Frisco, Texas, 75033, United States
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Accel Research Sites - Nona Pediatric Center - ERN - PPDS
Orlando, Florida, 32829, United States
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Advanced Clinical Research - Jordan Valley - ERN - PPDS
West Jordan, Utah, 84088, United States
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Alliance for Multispecialty Research
Syracuse, Utah, 84075, United States
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Alliance for Multispecialty Research -El Dorado
El Dorado, Kansas, 67042, United States
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Altus Research - Hunt - PPDS
Lake Worth, Florida, 33461, United States
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Benchmark Research
Austin, Texas, 78705, United States
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Caimed Dominicana S.A.S
Santo Domingo, Nacional, Dominican Republic
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Child Healthcare Associates - East Syracuse
East Syracuse, New York, 13210, United States
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Clinical Research Atlanta
Stockbridge, Georgia, 30281, United States
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Clinical Research Institute, Inc - CRN - PPDS
Minneapolis, Minnesota, 55402, United States
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Clinical Trials of Texas, Inc. - PPDS
San Antonio, Texas, 78229, United States
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Coastal Bend Research Center
Corpus Christi, Texas, 78404, United States
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Coastal Carolina Research Center
North Charleston, South Carolina, 29405, United States
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Coastal Pediatric Associates
Charleston, South Carolina, 29414, United States
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Cope Family Medicine - Ogden Clinic - CCT
Bountiful, Utah, 84010, United States
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Cottonwood Pediatrics
Murray, Utah, 84107, United States
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Cyn3rgy Research - ClinEdge - PPDS
Gresham, Oregon, 97030, United States
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DM Clinical Research - Kool Kids Pediatrics - ERN - PPDS
Houston, Texas, 77064, United States
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Hospital General Regional Dr. Marcelino Velez Santana
Santo Domingo, Nacional, Dominican Republic
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Hospital Materno Infantil San Lorenzo de Los Mina
Santo Domingo, Nacional, Dominican Republic
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IACT Health - Roswell - IACT - HyperCore - PPDS
Columbus, Georgia, 31904, United States
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Instituto Dermatologico y Cirugia de la Piel Dr. H Sede San Cristóbal
Santo Domingo, Nacional, Dominican Republic
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Instituto Dominicano de Estudios Virologicos IDEV
Santo Domingo, Nacional, Dominican Republic
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Johnson County Clin-Trials
Lenexa, Kansas, 66219, United States
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Lynn Health Science Institute
Oklahoma City, Oklahoma, 73112, United States
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Meridian Clinical Research (Endwell-New York) - Platinum - PPDS
Endwell, New York, 13901, United States
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Meridian Clinical Research (Hastings-Nebraska) - Platinum - PPDS
Hastings, Nebraska, 68901, United States
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Meridian Clinical Research (Norfolk, Virginia)
Norfolk, Virginia, 68701, United States
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Meridian Clinical Research (Omaha-Nebraska) - Platinum - PPDS
Omaha, Nebraska, 68134, United States
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Meridian Clinical Research (Sioux City - Iowa)
Sioux City, Iowa, 51106, United States
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Meridian Clinical Research - (Macon Georgia) - Platinum - PPDS
Macon, Georgia, 31210, United States
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Meridian Clinical Research - Charleston, SC
Charleston, South Carolina, 29414, United States
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Meridian Clinical Research - Family Practice Ports - Portsmouth - Platinum - PPDS
Portsmouth, Virginia, 23703, United States
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Olivo Medical and Wellness Center
Chicago, Illinois, 60618, United States
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Paradigm Clinical Research
La Mesa, California, 91942, United States
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Quality Clinical Research - HyperCore - PPDS
Omaha, Nebraska, 68114, United States
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South Ogden Family Medicine/Ogden Clinic - CCT Research
South Ogden, Utah, 84405, United States
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Sundance Clinical Research - Platinum - PPDS
St Louis, Missouri, 63141, United States
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Tekton Research
San Antonio, Texas, 78229, United States
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Tekton Research
San Antonio, Texas, 78244, United States
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Tekton Research - Georgia - PPDS
Chamblee, Georgia, 30341, United States
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University of Massachusetts Medical School, Molecu
Worcester, Massachusetts, 01655, United States
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Velocity Clinical Research - Albuquerque - PPDS
Albuquerque, New Mexico, 87102, United States
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Velocity Clinical Research - Banning
Banning, California, 92220, United States
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Velocity Clinical Research - Boise - PPDS
Meridian, Idaho, 83642, United States
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Velocity Clinical Research - Cincinnati - PPDS
Cincinnati, Ohio, 45242, United States
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Velocity Clinical Research - Gulfport - PPDS
Gulfport, Mississippi, 39503, United States
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Velocity Clinical Research - Metairie - PPDS
Metairie, Louisiana, 70006, United States
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Velocity Clinical Research - Providence - PPDS
East Greenwich, Rhode Island, 02818, United States
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Velocity Clinical Research - Valparaiso
Valparaiso, Indiana, 46383, United States
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Vital Prospects Clinical Research Institute PC - CRN - PPDS
Tulsa, Oklahoma, 74136, United States
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Wee Care Pediatrics - Kaysville
Kaysville, Utah, 84037, United States