Coronavinae infectious disease

This study looked at whether the mRNA-1273.214 COVID-19 vaccine is safe and works in infants as young as 12 weeks to under 6 months old. It was a small, early-stage trial that was stopped before completion. The main goal was to check for side effects like fever, fussiness, and in…

This early-phase trial tested a new therapy called CYNK-001, which uses natural killer cells from the placenta to fight COVID-19. It enrolled only 7 adults with moderate COVID-19. The study was terminated early, so we have limited information on safety and effectiveness.

This study tested whether breathing in nitric oxide gas could keep mild-to-moderate COVID-19 from becoming severe. Researchers enrolled 62 hospitalized adults who were breathing on their own. The goal was to see if the gas reduced the need for a breathing tube. The trial was stop…

This small Phase 2 trial tested an experimental drug called Auxora in 10 patients with critical COVID-19 pneumonia who were on ventilators. The goal was to see how the drug affected immune cells in the lungs and to check its safety. The study was terminated early, so results are …

This phase 2 trial tested whether adding aprepitant, a drug usually used for nausea, to standard care could help hospitalized COVID-19 patients recover faster. The study planned to enroll adults recently admitted to the hospital with COVID-19 and signs of lung involvement. Howeve…

This study tested the drug baricitinib in children aged 1 to 18 who were hospitalized with COVID-19 and needed extra oxygen. The goal was to see if the drug was safe and how it worked in kids. Only 6 children took part before the study was stopped early.

This early-stage study tested a new antibody drug (REGN14256) alone or with imdevimab in 25 adults with mild COVID-19 and no risk factors for severe illness. The goal was to check safety and whether the drug could lower virus levels. However, the trial was terminated early, so we…

This study tested a single injection of two lab-made antibodies (casirivimab and imdevimab) in children under 12 who are at high risk for severe COVID-19. The goal was to see how the drug behaves in the body, if it is safe, and if it triggers an immune response. Only 7 children t…

This study tested a single dose of casirivimab+imdevimab (REGN-COV2) in children hospitalized with COVID-19. The goal was to see how the drug behaves in the body and whether it is safe. However, the study was terminated early and only enrolled 2 participants, so we have very litt…

This study tested whether infusions of stem cells from donated fat tissue could help people with COVID-19. The trial planned to enroll 48 adults and compare four doses of stem cells against a placebo. The goal was to see if the treatment could reduce inflammation and improve oxyg…

This early-phase study tested whether hydroxychloroquine, a drug used for malaria and autoimmune diseases, could reduce the amount of virus in adults with mild COVID-19 not needing oxygen. Only 8 people took part before the trial was stopped early. The study was too small to draw…

This study explored whether analyzing sweat from fingerprints using a special camera could quickly detect COVID-19. Researchers enrolled 66 adults who had tested positive or negative for COVID-19 within the past week. Participants provided a fingerprint sweat sample and a blood s…

This study tested whether breathing in nitric oxide gas could prevent healthcare workers from catching COVID-19. The plan was to enroll 470 workers, but the trial was stopped early with only 24 participants. Workers in the treatment group inhaled the gas at the start and end of e…

This study collected blood, urine, stool, and respiratory samples from 615 COVID-19 patients and caregivers at Bordeaux University Hospital. The goal was to build a biobank for research on the virus and disease. The study was terminated early, but the samples may still help scien…

This study aimed to check how accurate several COVID-19 antibody tests are. Researchers used blood samples from 101 adults, including some taken before the pandemic and some from people with other infections. The goal was to see which tests best detect past COVID-19 infection.

This study tested whether placing a reminder sticker on the charts of adult hospital patients receiving IV fluoroquinolone antibiotics would encourage doctors to switch them to oral pills sooner. The trial involved 168 patients at a single hospital in Thailand. Unfortunately, the…