Chronic thromboembolic pulmonary hypertension

This early-stage study tests a new way to use a heart-lung machine (ECMO) in 4 people waiting for a lung transplant who also have heart failure from high blood pressure in the lungs. The goal is to see if this approach can keep them alive and stable until they receive a transplan…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study tests whether giving iron through a vein can help people with pulmonary hypertension (high blood pressure in the lungs) who also have low iron levels. Many patients with this condition have trouble absorbing iron from pills. The trial will compare intravenous iron to a…

This study tests whether combining two medications (Riociguat and Macitentan) with a balloon procedure to open blocked lung arteries can improve heart function in people with chronic thromboembolic pulmonary hypertension (CTEPH). The trial enrolls 15 adults who cannot have surger…

This study tests a new device for people with pulmonary hypertension, a condition where high blood pressure strains the heart. The device is implanted to help the heart pump better. About 30 adults with severe symptoms will take part to see if the device is safe and works well.

This phase 2 trial is testing whether two existing drugs, empagliflozin (used for diabetes) and ranolazine (used for chest pain), can improve right heart function in 30 people with pulmonary hypertension and right heart failure. Participants will receive one of the drugs plus sta…

This study explored whether a special type of MRI using inhaled xenon gas could detect changes in the small blood vessels of the lungs in people with pulmonary hypertension. The goal was to see if this imaging method could track disease progression or response to treatment. Howev…

This study is looking for specific protein patterns in the blood that could help diagnose chronic thromboembolic pulmonary hypertension (CTEPH), a rare but serious complication of blood clots in the lungs. Researchers will analyze blood samples from 120 people suspected of having…

This study is testing a standard screening method to find a condition called chronic thromboembolic pulmonary hypertension (CTEPH) in people who had a blood clot in their lungs 3 to 12 months earlier. Researchers will check if certain tests, like heart ultrasound or lung scans, c…

This study tests whether a mobile health program can help adolescents with pulmonary arterial hypertension increase their daily step counts. About 50 teens aged 10-21 will use a Fitbit and receive coaching to boost activity over 12 weeks. The goal is to improve exercise and quali…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study explores whether a simple, radiation-free scan of the nailbeds—called nailfold capillaroscopy—can help diagnose and monitor pulmonary hypertension (PH), a condition of high blood pressure in the lungs. Researchers will compare nailbed blood vessel measurements with inv…

This study follows people with chronic thromboembolic disease (CTD) or chronic thromboembolic pulmonary hypertension (CTEPH) — conditions where blood clots scar the lungs' blood vessels. Researchers track survival, exercise ability, oxygen use, and quality of life over time using…

This study looks at what happens when people with pulmonary arterial hypertension (PAH) switch from one medication (ambrisentan) to another (bosentan). Researchers will track 121 adults to see if their risk level, symptoms, and side effects change after the switch. The goal is to…

This study follows 50 adults who have had pulmonary endarterectomy surgery for chronic blood clots in the lungs. Researchers will measure walking ability, muscle strength, lung function, and frailty before and after surgery. The goal is to understand how recovery progresses and w…

This study is testing whether a bedside imaging technique called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of patients with chronic blood clots. Thirty-six people scheduled for surgery to remove these clots will be monitored with EIT befor…

This study looks at whether a special heart pressure wave test can better track recovery in adults with chronic blood clots in the lungs (CTEPH) who are getting a procedure to open blocked arteries (balloon pulmonary angioplasty). Researchers will measure walking distance, heart …

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI results with lung tissue from 30 patients awaiting lung transplant. The goal is …

This study involves 100 people with suspected pulmonary hypertension who are already scheduled for a right heart catheterization. During the procedure, doctors will take two extra blood samples from a specific position in the lung artery to analyze oxygen and other gas levels. Th…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to understand how these images change after treatments like blood transfusions or oxygen therapy. The study involves 125 adul…

This study looks at how balloon pulmonary angioplasty (BPA) changes heart and lung function in people with chronic blood clots in the lungs (CTEPH). Researchers will use advanced MRI scans before and after the procedure to measure blood flow and heart performance. The goal is to …

This study looks at how a surgery called pulmonary endarterectomy (PEA) affects the self-confidence of people with chronic thromboembolic pulmonary hypertension (CTEPH). Ten patients will fill out questionnaires about their confidence in managing their illness and communicating w…

This study is collecting information from 500 people with chronic thromboembolic pulmonary hypertension (CTEPH) in Russia. Researchers want to learn which factors most affect long-term survival and health. Participants will have their medical history, symptoms, and test results r…

This study will follow at least 700 people with pulmonary hypertension to track side effects and deaths related to targeted medications. Participants will be checked every 6 months using a computer system. The goal is to better understand the safety of these drugs in real-world u…

This study aims to find out how often people develop a serious lung condition called chronic thromboembolic pulmonary hypertension (CTEPH) after having a blood clot in the lungs (pulmonary embolism). Researchers will use heart ultrasounds to look for early signs of heart strain i…

This study is a national registry that collects information from 3,000 people with pulmonary hypertension (PH) treated at specialized centers across the U.S. Researchers will track how patients are diagnosed, treated, and how they do over time. The goal is to see if care follows …

This study looks at how well tiny blood vessels in the lungs recover after a procedure called balloon pulmonary angioplasty (BPA) in people with chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH is a condition where old blood clots block lung arteries, making it hard t…

This study looks at whether the way blood cells work and handle stress can help doctors detect and predict the course of pre-capillary pulmonary hypertension, a serious lung condition. Researchers will collect blood samples from 120 patients during routine visits over three years…