Central nervous system infectious disorder

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This study tested a new vaccine (NmCV-5) to protect infants against meningitis, a serious infection of the brain and spine. About 1,325 healthy infants in Mali received either the new vaccine or a standard one at 9 or 15 months old. The goal was to see if the new vaccine works as…

This completed study checked the safety of the Hexaxim vaccine in 713 infants aged 2 months and older in South Korea. Researchers tracked side effects like injection site reactions, fever, and crying after routine vaccination. The goal was to confirm the vaccine's safety in every…

This study looked at whether giving the meningitis B vaccine (Bexsero) and the pneumonia vaccine (PCV13) along with routine baby shots is safe and works well. About 1,200 healthy infants aged 6 to 12 weeks took part. Researchers checked for side effects like pain, redness, fever,…

This study tested whether giving a booster polio vaccine (sIPV) at the same time as MMR and hepatitis A vaccines is safe and works well in toddlers. About 889 healthy children aged 18 to 22 months who had already received their first polio and MMR shots took part. Researchers che…

This study tested a new vaccine called BK1310 in 370 healthy infants to see if it safely protects against several serious diseases: Hib, diphtheria, pertussis, tetanus, and polio. The vaccine was compared to existing vaccines. The goal was to check how well the infants' immune sy…

This study tested a new vaccine called BK1310 in 267 healthy infants to see if it protects against tetanus, diphtheria, pertussis, polio, and bacterial meningitis as well as existing vaccines. Infants received three doses, and researchers measured their immune responses. The goal…

This completed Phase 3 trial tested a new Sabin strain inactivated polio vaccine (sIPV) in 1200 healthy infants aged 2 months. The study compared the new vaccine to a standard polio vaccine to see if it was safe and triggered a strong immune response. The goal is to offer a more …

This study tested whether giving the polio vaccine (IPV) at the same time as a rotavirus vaccine (Rotarix PCV-free) is safe and works well in healthy Chinese infants aged 6-10 weeks. About 400 infants received the vaccines either together or a few weeks apart. The main goal was t…

This study tested a new combination vaccine called Shan6™, which protects against six diseases (diphtheria, tetanus, whooping cough, hepatitis B, Hib, and polio) in healthy infants and toddlers in Thailand. The trial involved 460 participants and compared Shan6™ to a similar 5-in…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This early-phase study tested whether infusing virus-fighting immune cells from a healthy donor could safely treat progressive multifocal leukoencephalopathy (PML), a serious brain infection in people with weak immune systems. Sixty adults with PML received up to three infusions …

This study tested whether adding a powerful HIV drug called FUZEON® to standard antiretroviral therapy could help people with HIV who also have a rare brain infection called PML. PML is caused by a virus that attacks the brain when the immune system is weak. The goal was to see i…

This early-phase study tested a drug called NT-I7 in 12 adults with progressive multifocal leukoencephalopathy (PML), a serious brain infection that occurs in people with weakened immune systems. The goal was to see if NT-I7 could increase the number of infection-fighting white b…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested whether applying vancomycin powder directly to the surgical wound during brain surgery can reduce infections. Over 1,100 adults having neurosurgery were randomly assigned to receive either the topical vancomycin or standard care. The main goal was to see if the …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new rapid diagnostic panel called QIAstat-Dx that can detect 15 different bacteria, viruses, and fungi causing meningitis and encephalitis in just one hour. Researchers compared its accuracy against standard lab tests using 170 stored spinal fluid samples. If …

This study aimed to create a quick, simple test to diagnose tuberculous meningitis (TBM) in children. TBM is a severe form of TB that affects the brain and is hard to detect with current methods, especially in places with limited resources. Researchers tested 51 inflammatory mark…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study looked at a blood test called Beta-D-glucan (BDG) to see how well it detects invasive fungal infections in people with weak immune systems. Researchers tested 280 patients and checked if two positive results within 15 days confirmed an infection. The goal is to help do…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study tested whether a polio vaccine (sIPV) is still effective when given at the same time as other routine vaccines for infants, like those for pneumonia, diphtheria, tetanus, and whooping cough. About 1,400 babies in Bangladesh and Pakistan received the polio vaccine eithe…

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This study tested whether adding transcranial magnetic stimulation (TMS) to standard exercise can reduce fatigue, pain, and improve walking in people with postpolio syndrome. 26 adults who had polio earlier in life and now have new symptoms took part. Half got TMS plus exercise, …

This study tested an online insomnia treatment program for adult survivors of childhood cancer. Over 1,500 survivors participated, using a web-based program that teaches healthy sleep habits and cognitive behavioral techniques. The goal was to see if improving sleep could also bo…

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This completed study tested blood samples from 878 people in Limousin, France, for antibodies against tick-borne encephalitis virus (TBEV). The goal was to see if the virus is present in the region, especially in patients with Lyme disease or neurological symptoms. Researchers al…

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This completed study reviewed medical records of 50 obese adults with HSV encephalitis (a brain infection) to see how different ways of calculating acyclovir dose affect survival. Researchers looked at patients treated between 2013 and 2019 at six hospitals. The goal was to find …

This study looks at how a specific gene mutation (RANBP2) affects the immune system in people with Acute Necrotizing Encephalopathy type 1 (ANE1), a rare brain condition triggered by infections. Researchers compared blood samples from 35 participants, including patients with the …

This study followed 76 women with congenital toxoplasmosis (a parasitic infection present from birth) to see if pregnancy increases the risk of eye inflammation (retinochoroiditis). Researchers checked eye exams done during pregnancy and after childbirth, comparing them to non-pr…

This study looked at 22 people with PML, a rare brain infection caused by the JC virus in those with weakened immune systems. Researchers collected blood, urine, and spinal fluid samples over six months to measure immune checkpoint molecules and antiviral responses. The goal was …

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at whether epidural or spinal anesthesia during childbirth leads to more infections in women with primary immunodeficiencies (weak immune systems). Researchers tracked 30 women from a national registry for 28 days after delivery to see if they developed serious …