Central nervous system infectious disorder

This Phase 3 trial tests a new vaccine designed to protect infants aged 3 to 5 months against four strains of meningococcal bacteria that cause meningitis and sepsis. About 880 healthy babies will receive either the experimental vaccine or a licensed comparator vaccine. Researche…

This Phase 3 trial tests a new meningococcal conjugate vaccine in 660 healthy children aged 2-6 years. The vaccine targets four strains (A, C, Y, W135) that cause meningitis. Participants receive one shot and provide blood samples to compare immune response with a licensed vaccin…

This study tests a new vaccine to protect young children (12-23 months old) against four types of meningococcal bacteria that can cause meningitis. About 1,040 toddlers will receive either the new vaccine or an existing one to see if the new vaccine is as safe and effective. The …

This Phase 3 trial tests a new vaccine against four types of meningococcal bacteria (A, C, Y, W135) that cause meningitis. About 1,040 healthy infants aged 6 to 11 months will receive either the experimental vaccine or a licensed comparator. Researchers will measure immune respon…

This early-stage trial is testing a new vaccine designed to protect against several types of meningococcal bacteria, which can cause meningitis and bloodstream infections. Researchers will enroll 150 healthy people aged 2 to 59 to check the vaccine's safety and how well it trigge…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests a new method of giving antibiotics for moderate-to-severe bacterial meningitis. Instead of only giving antibiotics through a vein, doctors will also inject them into the skull bone to help more medicine reach the brain. The goal is to improve recovery in 86 adult…

This study tests whether efavirenz, a drug used for HIV, can help people with Creutzfeldt-Jakob disease (CJD) live longer. CJD is a rare, rapidly fatal brain disorder. The trial will enroll 246 adults and randomly assign them to receive either efavirenz or a placebo. The main goa…

This study tests a new two-drug combination (Alpibectir and Ethionamide) added to standard treatment for tuberculosis meningitis, a serious brain infection. About 64 adults newly diagnosed with the condition will receive the drugs to see how well they reach the brain and how safe…

This study tests a new antibiotic combination (BV100 plus other drugs) against hard-to-treat infections like pneumonia and bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii. About 120 adults in the hospital will receive either the new combo or the best…

This study will compare two surgical methods for treating fluid collections in the brain that can occur after infant meningitis. One method uses a small camera (neuroendoscope) to remove debris and place a reservoir for drainage. The other is a standard burr hole drainage. The tr…

This study tests whether the antiviral drug aciclovir (or its pill form valacyclovir) works better than a placebo for treating meningitis caused by the herpes simplex virus type 2 (HSV-2). About 150 adults with confirmed HSV-2 meningitis will receive either the drug or a placebo,…

This study looks at whether a quick diagnostic test (BioFire FilmArray) can accurately predict the cause of meningitis or encephalitis in 182 adults. Participants with symptoms like fever, headache, or confusion will have their spinal fluid tested. The goal is to see if the test …

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This early-stage study tests a lab-made antibody called TBE025 in 18 healthy adults aged 18 to 55. The goal is to see if it is safe and how the body processes it when given through a vein. Participants receive one dose and are closely monitored for side effects. This research hel…

This study will recruit 100 sexual partners of people diagnosed with gonorrhea. Researchers will take an extra throat swab to analyze all the bacteria and their genes using a technique called metagenomics. The goal is to find hidden infections, antibiotic resistance, and see how …

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study aims to find what factors predict recovery in children with acute disseminated encephalomyelitis (ADEM), a rare brain condition. Researchers will follow 25 children aged 6 months to 18 years to see how many recover fully and how many have relapses. The study does not t…

This observational study will follow 50 patients with primary spondylodiscitis, a serious spinal infection, for one year. Researchers will track cure rates, pain levels, and daily function using standard treatments like antibiotics and braces. The goal is to understand how well c…

This study explores whether a blood test can identify the bacteria causing a brain abscess, potentially avoiding the need for brain surgery to get a sample. Researchers will compare the germs found in the blood with those found in the abscess during surgery in 15 adults. If succe…

This observational study will follow 100 children in Denmark who receive a stem cell transplant for blood cancer or other serious blood disorders. Researchers will test their thinking skills, physical abilities, and daily activity before the transplant and for one year after. The…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study follows 600 Chinese children who received standard vaccines against polio, measles, mumps, rubella, and hepatitis A. Researchers will test their blood to see if protective antibodies remain 5 years after vaccination. The goal is to understand how long vaccine protectio…

This study will compare how well an AI program (Blings) measures speech clarity in 40 adults with speech disorders from stroke or other neurological conditions. Two speech therapists will also rate the same speech samples. The goal is to see if the AI can reliably replace or assi…

This study will follow 32 children diagnosed with their first episode of acute disseminated encephalomyelitis (ADEM), a rare brain inflammation that usually follows an infection. Researchers will check if early MRI scans, spinal fluid tests, and symptoms can predict which childre…

This study will follow 4,000 children in Cambodia to understand how common Japanese Encephalitis (JE) is and how often it spreads without symptoms. Researchers will compare healthy children with those hospitalized for fever and brain-related symptoms. The goal is to measure the t…

This study will follow 175 children and young adults who had a bone marrow transplant before age 18. Researchers will test their thinking, memory, and attention skills, and check for links to physical health issues like metabolism and fitness. The goal is to find early warning si…