Cardiac rhythm disease

This trial tests whether using cryoballoon ablation as the first treatment for persistent atrial fibrillation (AF) is more effective and safer than starting with anti-arrhythmic drugs. Adults aged 18-75 with symptomatic persistent AF and a structurally normal heart are eligible. …

This early-stage trial is testing a new gene therapy called AB-1002 in people with advanced heart failure (NYHA Class III). The therapy is given as a single infusion directly into the heart's blood vessels, aiming to deliver a gene that may help heart muscle pump more effectively…

This trial tests a special implantable cardioverter-defibrillator (ICD) that uses a single lead to sense both heart chambers, aiming to detect atrial fibrillation and other arrhythmias early. It includes 56 people who need a single-chamber ICD and are in normal sinus rhythm at th…

This study tested a new type of pacemaker that doesn't use wires (leads) to help both the upper and lower chambers of the heart beat in sync. It involved 464 people with slow heart rhythms who needed a pacemaker. The main goals were to see if the device was safe and worked well a…

This study tested a new type of pacemaker that doesn't need wires (leads) to connect to the heart. It was implanted directly into the heart in over 1,200 people with slow heart rhythms. The goal was to see if it is safe and works well. The study found that most patients had no se…

This early study tested a new device called the FieldForce™ Ablation System in 34 people with ventricular arrhythmias (dangerous heart rhythms). The device uses pulsed electric fields to destroy the small areas of heart tissue causing the problem. The main goal was to see if the …

This study tested whether removing the ligament of Marshall during coronary artery bypass surgery could prevent a common complication: atrial fibrillation. 220 high-risk patients were randomly assigned to get the extra procedure or standard surgery alone. The goal was to see if t…

This study tested whether permanent pacemakers can be safely implanted using only ultrasound (transthoracic echocardiography) instead of traditional X-ray guidance. Thirty-one adults with arrhythmias who needed a pacemaker took part. The goal was to see if the procedure could be …

This pilot study tested a procedure called bilateral sympathectomy, which cuts certain nerves to the heart, in 45 Chagas disease patients with implantable defibrillators (ICDs) who had frequent dangerous heart rhythms. Participants were randomly assigned to receive the nerve-cutt…

This study tested a new type of wire (lead) for implantable heart devices that deliver shocks to stop dangerous fast heart rhythms. Researchers checked how safe and effective the lead was in 998 people who needed a defibrillator or heart failure device. The lead was placed in a s…

This completed study tested a new type of implantable defibrillator (EV ICD) in 14 Japanese patients with dangerous heart rhythms. The device is placed under the skin, outside the heart and blood vessels, to deliver a shock if a life-threatening rhythm occurs. Researchers checked…

Researchers are testing whether a new arm-worn heart monitor called the HeartWatch can record heart rhythms as well as the Holter and event recorders used in clinics. Adults who have been recommended for a heart monitor wear the HeartWatch on the upper left arm at the same time a…

This study tests whether a 7-day adhesive ECG patch (MEMO Patch) can detect more heart rhythm abnormalities than a conventional 24-hour Holter monitor in adults who experience palpitations or dizziness. Participants wear both devices at the same time for the first day, then conti…

This trial tests whether a wearable patch called MEMO Patch V2 can detect heart rhythm disorders (arrhythmias) more effectively than the standard 24-hour Holter monitor. Adults with symptoms like palpitations or dizziness, or those who have had a stroke of unknown cause, will wea…

This study investigates whether an Apple Watch can accurately detect heart rhythm problems (arrhythmias) in children aged 6 to 21 who are already scheduled for standard heart monitoring. Researchers will compare the watch's ECG and heart rate readings to those from conventional c…

This study tested a non-invasive mapping system (Cardioinsight®) to help doctors treat heart rhythm disorders. It included 492 patients who needed ablation, pacemaker implantation, or risk assessment for sudden death. The goal was to see if the mapping system improves outcomes co…

This study tested whether a special algorithm in a pacemaker can accurately diagnose sleep apnea in people with heart problems. Researchers compared the pacemaker's readings to a standard overnight sleep test in 66 participants. They also looked for a link between sleep apnea sev…

This study tested a new non-invasive tool called ECG-Imaging that uses many electrodes on the body to create a 3D map of the heart's electrical activity. The goal was to see if it can more accurately locate the source of heart rhythm problems compared to a standard ECG. 362 parti…

Researchers are testing whether a cardiac rehabilitation education video helps people with cardiovascular implantable electronic devices (CIEDs) such as pacemakers and defibrillators increase their physical activity. The trial enrolls adults aged 20 to 100 who have had a CIED for…

This trial compares two standard local anesthetics given during pacemaker or defibrillator surgery: a mixture of lidocaine and bupivacaine versus lidocaine alone. Researchers want to see if the mixture reduces postoperative pain and the need for narcotic painkillers. About 350 pe…

This study tested a computer algorithm called CartoFinder to help doctors better identify and treat complex heart rhythm problems (arrhythmias). 70 adults with persistent atrial fibrillation (a type of irregular heartbeat) took part. The goal was to see if the algorithm could imp…

This study looked at whether a 12-week virtual exercise program could help women with cardiac implantable electronic devices (CIEDs) improve their physical fitness, quality of life, and mental health. Twenty women took part, doing either high-intensity interval training (HIIT) or…

This study tested whether online group exercise training could help children aged 6-18 with pacemakers become more active and improve their strength and quality of life. 36 children were split into two groups: one did online exercise sessions three times a week for eight weeks, w…

This study looks at a new, less invasive way to monitor blood flow during heart ablation procedures. Doctors will use a special device to track heart function beat-by-beat. The goal is to see if this method helps improve care for 27 adult patients having heart ablation.

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers caused by atrial fibrillation. Researchers will compare CT scans taken before and 3 months after the procedure in 200 adults. T…

This study aims to establish national reference levels for radiation exposure during X-ray guided procedures to correct heart rhythm disorders, such as pacemaker insertions and ablations. Researchers will collect radiation dose data from over 4,000 adult patients undergoing these…

This study looks at whether a new digital stethoscope can help parents of infants with fast heart rates (tachyarrhythmia) record clear heart readings at home. About 100 babies under 1 year old will take part. The goal is to see if parents can capture good-quality ECGs, which migh…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This study tests whether wearing a heart monitor for 14 days can detect dangerous heart rhythms in people with mitral valve prolapse (a common heart valve condition) better than the usual 24-hour test. About 60 adults with MVP will wear a patch monitor for two weeks. The goal is …

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This study follows 340 people with atrial fibrillation who are having their first ablation procedure. Researchers will track heart rhythm using remote monitoring, along with imaging and blood tests, to find which factors—like patient health, heart structure, or electrical signals…

This study looked at whether it's safe to skip the defibrillation test when implanting a subcutaneous implantable cardioverter-defibrillator (S-ICD). The test involves purposely triggering a dangerous heart rhythm to make sure the device can stop it. About 965 people took part. T…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at whether a special mapping tool called vMap can help doctors perform heart ablations more efficiently for people with irregular heartbeats (arrhythmias). Researchers tracked 112 patients to see if using vMap reduced procedure time and improved success rates. T…

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study looked at how well a procedure called catheter ablation works for treating fast heart rhythms in people with congenital heart disease. Researchers treated 40 patients and followed them for one year to see if the abnormal heart rhythm came back. The goal was to understa…

This study tested whether a small, band-aid-like heart monitor (Zio patch) can be worn by children for up to 14 days. It involved 36 kids aged 1 to 17 years. The goal was to see if the patch sticks well and gives clear heart signals. The study did not test any treatment, only the…

This study tracked 1,826 people who received a small implantable heart monitor (Confirm Rx) to check for irregular heartbeats. Over 12 months, researchers recorded how often the device caused serious problems and how well it worked in daily life. The goal was to see if the monito…

This study tested a wearable smart textile sensor system called SimpleSense in 334 people. The device uses special sensors in a harness to record heart signals, breathing, and body movement. Researchers compared its readings to standard hospital monitors to see if it works just a…

This pilot study looked at whether giving extra oxygen during heart surgery (when a heart-lung machine is used) affects kidney function afterward. 104 adults having elective heart surgery were randomly assigned to receive either high or normal oxygen levels. The main goal was to …

This completed pilot study looked at how moderate exercise affects heart function and dangerous heart rhythms in 20 adults with arrhythmogenic cardiomyopathy (ACM). Participants did different types of exercise while doctors measured heart pressures and electrical activity. The go…

This completed registry study followed over 5,000 people with heart rhythm disorders who received Abbott devices during standard procedures. The goal was to collect real-world data on safety and how well the devices work. No new treatments were tested; instead, the study observed…

This completed study looked at how the heart medication amiodarone behaves in children aged 0 to 18 with heart rhythm disorders. Researchers took blood samples from 57 children to measure drug levels and understand how the body processes it. The goal was to find the best dose for…

This pilot study enrolled 5 people with hypertrophic cardiomyopathy who needed an implantable cardioverter defibrillator (ICD) but did not require pacing. Participants were randomly assigned to receive either a subcutaneous ICD (placed under the skin) or a transvenous ICD (with l…

This study tested a special breathing technique during atrial fibrillation ablation to see if it reduces catheter movement. Fifty-two adults with atrial fibrillation were given both standard and high-frequency, low-volume ventilation during their procedure. The goal was to see if…

This study tested a noninvasive monitor that uses light to measure oxygen levels in the liver of children with heart conditions. Researchers wanted to see if this method could replace the usual needle-based blood draw. The study included 100 children undergoing heart catheterizat…

This completed study looked at 110 people with cardiac amyloidosis, a condition where protein deposits build up in the heart. Researchers implanted a small device under the skin to continuously monitor heart rhythms for up to several years. The goal was to learn more about when a…

This study used a special brain imaging technique called near-infrared spectroscopy to see how the brain responds to pain and sounds while people are under general anesthesia. 44 healthy volunteers aged 12-30 were given either a painkiller (remifentanil) or a placebo. The goal wa…

This study looked at whether silent myocardial ischemia (reduced blood flow to the heart without chest pain) increases the risk of heart problems or death in people with coronary heart disease. Researchers followed participants for one to three years. The goal was to better under…

This study aimed to find out if certain genes make people more likely to die suddenly from a heart problem. Researchers looked at the DNA of 2,500 people to see if specific gene variations were linked to sudden cardiac death. No treatments or interventions were given; the goal wa…

This study looked at 72 healthy male triathletes aged 20-54 who competed in a long-distance triathlon. Researchers checked heart function and rhythm before, during, and after the race to see if intense exercise causes temporary heart strain or irregular beats. The goal was to bet…

This completed study from the University of São Paulo measured physical activity levels and quality of life in 100 adults with cardiac arrhythmias. Researchers used questionnaires to see how active patients were and how they felt physically and mentally. The goal was to understan…