Adrenal gland hyperfunction

This study tests if a less invasive needle-based treatment (thermal ablation) works as well as surgery to cure a hormone disorder called primary aldosteronism, which causes high blood pressure. About 122 adults with the condition will be randomly assigned to one of the two treatm…

This study compares two treatments for a condition called primary aldosteronism, where a small adrenal gland tumor causes high blood pressure. One treatment is laparoscopic surgery to remove the tumor; the other is radiofrequency ablation (RFA), which uses heat delivered through …

This study compares a new, less invasive procedure called EUS-RFA to standard surgery for treating left-sided adrenal tumors that cause high blood pressure and other hormone-related issues. About 60 participants will receive the new procedure, which uses a thin tube inserted thro…

This study tests a new drug called HRS-1780 in 60 adults with primary aldosteronism, a condition where the adrenal glands make too much of a hormone that raises blood pressure. Participants will receive either HRS-1780 or a placebo to see if the drug safely lowers blood pressure …

This study tests a new drug called baxdrostat in about 250 adults with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, causing high blood pressure. Participants take baxdrostat or a placebo daily for 8 weeks to see if it lowers blood pressur…

This study tests a new way to dose a common blood pressure medication (MRA) for people with primary aldosteronism, a condition where the body makes too much aldosterone. Doctors will use a blood test for renin, a hormone, to guide dosing. The goal is to see if this leads to bette…

This study tests a procedure called superselective adrenal artery embolization (SAAE) against the standard pill spironolactone for people with idiopathic hyperaldosteronism, a condition that causes high blood pressure. About 172 participants will be randomly assigned to either th…

This study tests whether a procedure called superselective adrenal artery embolization can improve blood vessel function in people with primary aldosteronism, a condition where the adrenal glands make too much of the hormone aldosterone, causing high blood pressure. The procedure…

This study is testing a procedure called EUS-RFA, which uses a thin needle guided by ultrasound to heat and destroy small tumors in the pancreas or adrenal glands. About 138 participants will receive this treatment as part of their standard care and be followed for up to 5 years.…

This phase 2 study tests a radioactive tracer called [68Ga]Ga-PentixaFor to see if it can better identify adrenal tumors that produce excess hormones like aldosterone or cortisol. About 80 adults with known adrenal tumors and high hormone levels will receive the tracer before a P…

This study is testing a more accurate way to diagnose primary aldosteronism, a common but often missed cause of high blood pressure that can be cured with surgery. Researchers will measure urine aldosterone using a precise lab method (LC-MS/MS) in 800 healthy volunteers and patie…

This study tests whether a new type of PET scan (68Ga-Pentixafor) can accurately identify which adrenal gland is overproducing hormones in patients with both aldosterone and cortisol excess. About 130 adults will receive the scan and standard vein sampling, then researchers compa…

This study tests a new steroid-based blood test to see if it can more accurately diagnose primary aldosteronism—a common, treatable cause of high blood pressure—in people who are already taking blood pressure medications. Current tests often require patients to temporarily stop o…

This study tests whether a special PET/CT scan (68Ga-Pentixafor) is as good as the standard adrenal vein sampling (AVS) at identifying which adrenal gland is causing high blood pressure and excess cortisol. About 178 adults with both conditions will be randomly assigned to one te…

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This observational study is looking at whether people with primary aldosteronism (a cause of high blood pressure) have hormone levels that vary in cycles or differ between day and night. Researchers will collect urine samples over 24 hours from 100 participants to see if this met…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study looks at whether a new cutoff for a blood test (aldosterone-renin ratio) can better identify people with primary aldosteronism, a common cause of high blood pressure. About 150 adults with hypertension and certain lab results will be tested using the new cutoff and the…

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study aims to learn more about how adrenal tumors form and to test new treatment options for adrenal cancer. Researchers will study up to 500 adults who have an adrenal tumor seen on imaging. The goal is to improve understanding and find better ways to treat these tumors.

This study follows 521 patients who had adrenal gland surgery for primary aldosteronism, a condition causing high blood pressure. Researchers want to see how often the remaining adrenal gland fails to produce enough cortisol after surgery, especially in patients who also had extr…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study follows 5,000 people with primary aldosteronism, a common but often missed cause of high blood pressure that raises heart and kidney risks. Researchers will track treatments like medication, surgery, and other procedures over five years to see which works best. The goa…

This study follows 1,000 adults with primary aldosteronism—a condition where the adrenal glands make too much aldosterone—to see how it affects thinking and memory over up to 5 years. Participants will take regular cognitive tests and have medical check-ups. The goal is to learn …

This study compares three ways of doing a specialized blood test (adrenal vein sampling) to help doctors decide the best treatment for people with primary aldosteronism, a condition causing high blood pressure due to adrenal gland issues. About 456 adults aged 18-70 with this con…

Primary aldosteronism is a common but often missed cause of high blood pressure. This study will analyze blood, urine, and adrenal tissue from 400 people to find biological markers that could lead to earlier diagnosis. Researchers hope to use advanced lab techniques and machine l…

This study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …

This study looks at a special blood test called adrenal venous sampling (AVS) used in people with primary aldosteronism, a condition where the adrenal glands make too much of a hormone that raises blood pressure. The goal is to see how well AVS helps doctors choose the right trea…

This study is building a large group of 600 adults with various adrenal diseases, like Cushing's syndrome and adrenal tumors. Researchers will track their standard treatments (surgery, radiation, or medication) and outcomes. The goal is to learn more about these conditions, impro…

This study looks at whether taking one dose of dexamethasone at bedtime can make screening for primary aldosteronism more accurate in people already taking blood pressure medications. Primary aldosteronism is a condition where the adrenal gland makes too much aldosterone, causing…