Adrenal gland hyperfunction
MONDO:0006640Excess production of adrenal cortex hormones.
Also known as: adrenal gland hyperfunction, hyperadrenalism, hypercortisolemia, disorder of corticoadrenal overactivity, hyperadrenocorticism, hypercorticism, hyperfunction, adrenal gland, hyperfunction, adrenocortical
55 clinical trials for this condition and its sub-types.
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Broader categories
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Adrenal surgery helps blood pressure in hormone disorder, but many still need meds
Disease control CompletedThis study looked at 43 patients who had one adrenal gland removed to treat primary hyperaldosteronism, a condition where a hormone imbalance causes high blood pressure. Researchers checked blood pressure and medication use 1 month, 1 year, and many years after surgery. They foun…
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Zapping adrenal tumors could lower blood pressure without surgery
Disease control CompletedThis study tested a procedure called radiofrequency ablation, which uses heat to destroy a small adrenal gland tumor that causes high blood pressure. Researchers wanted to see if it could safely lower blood pressure in 31 patients with primary aldosteronism. The goal was to reduc…
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New pill shows promise for controlling blood pressure in rare hormone disorder
Disease control CompletedThis study tested a new drug called CIN-107 in 15 adults with primary aldosteronism, a condition where the body makes too much of a hormone that raises blood pressure. Participants took the drug once daily for up to 12 weeks to see if it safely lowered blood pressure. The goal wa…
Phase: PHASE2 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New hope for Hard-to-Control blood pressure: finerenone shows promise
Disease control CompletedThis study tested a drug called finerenone in 55 adults with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, leading to high blood pressure. The goal was to see if finerenone can safely lower blood pressure over 12 weeks. Participants starte…
Phase: PHASE4 • Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School • Aim: Disease control
Last updated Jun 26, 2026 16:02 UTC
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New blood test thresholds could sharpen diagnosis of hidden high blood pressure cause
Diagnosis CompletedThis study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …
Phase: NA • Sponsor: University Hospital, Caen • Aim: Diagnosis
Last updated Jun 28, 2026 00:00 UTC
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Pacemaker algorithm could spot sleep apnea without extra tests
Diagnosis CompletedThis study tested whether a special algorithm in a pacemaker can accurately diagnose sleep apnea in people with heart problems. Researchers compared the pacemaker's readings to a standard overnight sleep test in 66 participants. They also looked for a link between sleep apnea sev…
Phase: NA • Sponsor: University Hospital, Caen • Aim: Diagnosis
Last updated Jun 27, 2026 12:03 UTC
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Simple blood test could uncover curable high blood pressure
Diagnosis CompletedThis study tested whether a simple blood test, called the aldosterone renin ratio (ARR), could help doctors find more cases of primary aldosteronism—a common but often missed cause of high blood pressure that can be cured with surgery or treated with specific medications. Researc…
Sponsor: The Cleveland Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Researchers measure breathing, strength, and quality of life in hospitalized endocrine patients
Knowledge-focused CompletedThis completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…
Sponsor: Uşak University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Potassium loss in hyperaldosteronism: a new MRI insight
Knowledge-focused CompletedThis study looked at whether potassium levels in body tissues change in people with primary hyperaldosteronism, a condition causing high blood pressure and electrolyte imbalances. Researchers used a special MRI technique to measure potassium in 21 patients before and after treatm…
Sponsor: University of Erlangen-Nürnberg Medical School • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC