Zapping adrenal tumors could lower blood pressure without surgery

NCT ID NCT02756754

Completed Disease control Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a procedure called radiofrequency ablation, which uses heat to destroy a small adrenal gland tumor that causes high blood pressure. Researchers wanted to see if it could safely lower blood pressure in 31 patients with primary aldosteronism. The goal was to reduce or stop the need for blood pressure medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiofrequency ablation
What this could lead to: If successful, this could provide a less invasive treatment option for patients with primary aldosteronism, potentially reducing or eliminating the need for lifelong blood pressure medication.
What could go wrong: This is a small, early-phase study with only 31 participants, so results may not apply to everyone. The procedure carries risks such as bleeding or damage to nearby tissues, and long-term effectiveness is not yet proven.

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Conditions

The condition(s) this trial relates to.

adrenal cortex adenoma aldosterone-producing adrenal cortex adenoma ectopic ACTH secretion syndrome hyperaldosteronism primary aldosteronism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADRENAL ADENOMA PRIMARY ALDOSTERONISM

Contacts and locations

Locations

CHU Bordeaux

Bordeaux, France
CHU de Toulouse

Toulouse, 31059, France

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