Adrenal gland hyperfunction

This study tests if a less invasive needle-based treatment (thermal ablation) works as well as surgery to cure a hormone disorder called primary aldosteronism, which causes high blood pressure. About 122 adults with the condition will be randomly assigned to one of the two treatm…

This study tests whether the drug eplerenone works better than amlodipine for controlling high blood pressure in Black adults who carry a specific gene variant (LSD1 risk allele). About 300 participants will follow a controlled diet and take escalating doses of one of the two dru…

This study tests a special PET scan (11C-Metomidate) to better identify adrenal tumors that cause high blood pressure and can be cured with surgery. About 100 adults with suspected adrenal-related hypertension will receive the scan, which is non-invasive and may replace the curre…

This study follows 100 adults aged 35-70 with mildly elevated blood pressure to see how their aldosterone hormone system changes over time. Participants will eat special high-salt or low-salt diets for a few days each year to test how their body responds. The goal is to better un…

This trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…

This study looks at a specific genetic change found in some people with high blood pressure. Researchers want to see if this change is linked to a condition called primary aldosteronism, which can sometimes be cured with surgery. About 76 men from a larger Swedish health study wh…

This study follows 150 patients with functional adrenal tumors to see how their heart and blood pressure change before and after surgery. Researchers will use heart ultrasounds and blood pressure monitoring to understand recovery and risks. The goal is to help doctors choose bett…