Acute lung injury

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this …

This study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…

This study looked at over 2,000 trauma patients who needed help breathing before arriving at the hospital. Half were given a supraglottic airway device (like an LMA or King tube) first, while the other half received standard care. The goal was to see which approach led to more pa…

This study looked at whether the drug dexmedetomidine, given during laparoscopic surgery for rectal or sigmoid colon cancer, can protect the lungs of patients aged 60 and older. The trial included 64 participants and measured oxygen levels and other breathing indicators. The goal…

This study looked at 90 adults with severe ARDS (a serious lung condition) who were on breathing machines. It compared two ways of using the machine to open up the lungs and improve oxygen levels. The goal was to see which method works better using ultrasound and blood oxygen mea…

This study tested whether using the World Health Organization's trauma care checklist helps injured patients recover better. Sixty adults with trauma were randomly assigned to standard care or care with the checklist. Researchers measured pain, injury severity, complications, and…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested whether measuring a protein called Clara cell protein 16 (CC16) in the blood can help doctors tell the difference between two types of lung fluid buildup: one caused by heart problems and another caused by lung injury. Researchers measured CC16 levels in 100 ICU…

This completed study tested an artificial intelligence model that analyzes chest CT scans to help diagnose and manage Acute Respiratory Distress Syndrome (ARDS). Researchers used data from 400 ICU patients to train the AI to classify ARDS severity, recommend treatments, and predi…

This pilot study tested a non-invasive device that stimulates the vagus nerve (nVNS) in patients hospitalized with mild-to-moderate traumatic brain injury. The goal was to see if adding nVNS to standard care could prevent severe lung inflammation and the need for a breathing mach…

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study tested whether a social robot could reduce fear and pain in children aged 5 to 10 during wound dressing. Sixty children were split into two groups: one interacted with the robot while getting their wound dressed, and the other received standard care. Researchers measur…

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This study tested whether giving the sedative dexmedetomidine during lung surgery helps the lungs re-inflate better afterward. One hundred adults having a lung lobe removed received either the drug or a placebo. The goal was to see if the drug improves lung aeration and reduces c…

This study looks at trauma patients with severe bleeding to understand how early blood transfusions affect their chances of survival and blood clotting. Researchers will compare patients who receive a transfusion within two hours of arrival to those who do not, and also examine t…

This study looks at whether storing blood for a long time before transfusion affects death rates and complications in severely injured trauma patients. Researchers will review records of 300 patients aged 18-75 who received large transfusions. The goal is to understand if blood s…

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study follows 3,000 people who received stitches for traumatic wounds in an emergency department. Researchers track how the wounds heal and look for factors that lead to complications like infection or stitches coming apart. The goal is to identify what makes some wounds hea…

This study looked at 265 severely injured adults in France to see if getting them to the hospital within the recommended 60 minutes (the 'golden hour') improves their chances of survival. Researchers checked if following these time guidelines helped patients live at least 24 hour…

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …

This completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.

This study looked at 55 adults with arm or leg injuries to see if using a tourniquet before reaching the hospital made a difference. Researchers compared those who had a tourniquet placed to those who did not, checking for shock, blood transfusions, and other complications. The g…

Researchers looked at records from over 58,000 adults who had fall injuries to build a simple scoring system that estimates the chance of dying within 30 days. The tool uses age, sex, and vital signs taken in the emergency room. This study did not test any treatment—it only aimed…

This pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…

This study looked at 13 adults who had been on a breathing tube for at least 2 days and were at risk for breathing trouble after the tube was removed. Researchers compared two types of noninvasive breathing support: one that senses the patient's own breathing signals (NAVA) and o…

This study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…

This study tested whether giving a gas sedative (isoflurane) instead of standard IV drugs could reduce the energy delivered to the lungs by the breathing machine in 40 ICU patients. The goal was to see if this approach might lower the risk of lung injury. The trial was small and …

This study tested a new breathing machine mode called NAVA in 15 patients recovering from acute lung injury. The goal was to see how their bodies responded to different levels of support from the machine. The study did not aim to treat or cure the lung injury, but to gather infor…

This study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…

This study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…

This study checked how well the Trauma and Injury Severity Score (TRISS) predicts survival and the need for intensive care or surgery in 204 trauma patients at one hospital in Iraq. Researchers measured the score within 6 hours of arrival and tracked outcomes. The goal is to see …

This study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

Researchers studied 407 children under 18 who had whole-body CT scans after trauma. They looked at injury details, physical exams, and lab results to create a scoring system called WHOLE. The goal is to help emergency doctors decide when a full-body scan is truly needed, reducing…

This study tested a new method called continuous anterior chest compression (CACC) to help people with severe lung injury (ARDS) breathe better. Twenty adults on ventilators were studied to see if pressing on the chest improved lung function compared to lying on the stomach. The …

This study followed 283 adults who needed intensive care for severe COVID-19 lung damage (ARDS) in Poland. Researchers tracked who survived up to 4 years later and asked survivors about their quality of life, breathing, and daily function. No new treatment was tested—the goal was…

This study looked at 76 ICU patients with severe pneumonia who were placed on a lung machine (ECMO) and given minimal ventilator support. Researchers wanted to see if this approach changed how well the kidneys worked. They reviewed medical records from 2019 to 2023, comparing uri…

This study looked at 263 severely injured trauma patients to find out how often they develop early blood clotting problems (called trauma-induced coagulopathy) and excessive clot breakdown (hyperfibrinolysis) within the first hour of arriving at the emergency room. Researchers us…

This study looked at anonymous medical records from over 55,000 past ICU patients to find patterns that could help predict three life-threatening conditions: sepsis (body-wide infection), ARDS (severe lung injury), and acute kidney injury. Researchers used computer models to anal…

This study tested whether using ultrasound to guide the placement of catheters in the femoral artery and vein (in the groin) reduces complications in severely injured patients in the intensive care unit. The trial involved 136 adults with severe trauma who needed these catheters.…

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This study looked at 15,000 trauma patients treated at a Swedish hospital over 10 years. Researchers focused on those with serious neck or face injuries to understand what causes deadly bleeding and how it is managed. The goal is to improve care for future patients with these inj…