University Of Southern California

This early-phase trial is testing whether combining two immunotherapy drugs (botensilimab and balstilimab) with a low-sugar, calorie-restricted diet and high-dose vitamin C is safe and tolerable for people with a specific type of advanced colorectal cancer (KRAS-mutant). The stud…

This study compares a longer course of the fertility drug Clomid (taken throughout ovarian stimulation) to the standard 5-day Clomid protocol in 120 women with diminished ovarian reserve undergoing IVF. The goal is to see if the extended protocol increases the number of mature eg…

This early-phase trial tests a new cell therapy for people with advanced triple negative breast cancer that has stopped responding to standard treatments. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells carrying a …

This study tests whether using HEPA air filters at home can slow the progression of heart disease in 112 adults aged 65–84 with a history of ischemic heart disease. Participants will use a real HEPA filter and a sham filter for several months each, and researchers will measure ch…

This study tests if a cream called imiquimod can treat pre-cancerous spots in the mouth. Twenty adults with these spots will apply the cream and get two follow-up biopsies. The goal is to see if the spots shrink and if the abnormal cells become less severe.

This early-stage trial tests if a donated bladder can be transplanted using robotic surgery in 5 adults with severe bladder damage. The goal is to see if the transplant works and is safe. Participants will need lifelong anti-rejection medication.

This study compares two common surgeries—joint replacement (arthroplasty) versus using screws/pins (internal fixation)—for treating a certain type of hip fracture in adults aged 60 and older. The goal is to see which approach helps people live longer, walk better, and spend fewer…

This early-phase trial tests a new drug called AU409 in 36 adults with advanced liver cancer or solid tumors that have spread to the liver. The main goals are to find the safest dose and check for side effects. Researchers also look for early signs that the drug might shrink or s…

This study tests whether adding the drug sarilumab to chemotherapy (capecitabine) can eliminate tiny amounts of cancer left behind after standard treatment in people with triple negative breast cancer, a very aggressive type. The goal is to prevent the cancer from coming back and…

This study is testing whether a blood test called a liquid biopsy can accurately detect breast cancer. Researchers will compare the blood test results with mammograms and standard tissue biopsies in 490 women. If the blood test works well, it could offer a less invasive way to sc…

This study is testing whether a special ultrasound with contrast dye, combined with computer analysis, can better tell if a breast lump is harmless or cancerous. About 100 women with suspicious breast lumps will get this imaging before their planned biopsy. If the method works, i…

This study is testing whether a blood test that measures a substance called miRNA-371 can accurately detect active testicular cancer in people who have already had their primary tumor removed. Researchers will compare the blood test results with surgical findings to see how well …

This study tests whether taking zolpidem (Ambien) for a few days before and after lumbar spine fusion surgery can improve pain and function. About 140 adults with degenerative lumbar disease will be randomly assigned to receive either zolpidem or a placebo. The goal is to see if …

This phase 2 trial tests whether a curcumin supplement (C3 complex with piperine) can reduce inflammation and improve symptoms in people with certain blood disorders, including CCUS, low-risk MDS, and MPNs. Thirty participants will receive either curcumin or a placebo for 12 mont…

This study tests whether a gentle massage technique called manual lymphatic drainage (MLD) can reduce swelling, pain, and other side effects in women receiving radiation therapy after breast-conserving surgery for early-stage breast cancer. Fifty women will be enrolled, and resea…

This study tests three types of diabetic boots to see which helps people with foot ulcers heal best. Some boots give reminders through a smartwatch to encourage wearing them as directed. The goal is to improve healing, sleep, and quality of life for 210 adults with diabetes.

This study is testing a mobile app called CarePair that helps family caregivers of people with dementia find services and support. About 80 caregivers will use the app for six weeks to see if it reduces stress, depression, and feelings of being overwhelmed. The goal is to make ca…

This study tests whether middle-school students who have received disciplinary referrals can benefit from being trained as peer coaches. The Peer Coach Training (PCT) program is a strengths-based behavioral intervention that teaches skills for helping peers. Researchers will comp…

This study tests whether a very low dose of radiation (2 Gy) can relieve bone pain in people with multiple myeloma that has spread to the bones. The goal is to see if this gentler approach works as well as standard radiation but with fewer side effects and less disruption to chem…

This study tests whether a friendly robot, personalized to each user, can help college students with anxiety complete their cognitive behavioral therapy (CBT) exercises at home. About 140 students with mild to moderate anxiety will use the robot for 6 weeks. The goal is to see if…

This study tests whether a supervised golf exercise program can improve physical function, mental health, and quality of life in prostate cancer survivors who are on hormone therapy. Twenty men aged 55-85 with little or no golf experience will participate. The program includes wa…

This study tests whether blood flow restriction therapy or pneumatic compression can reduce delayed onset muscle soreness (DOMS) after exercise. Researchers will measure muscle function and soreness in 33 healthy, recreationally active adults aged 18-30. The goal is to find a bet…

This study tests whether a specially designed dental environment with softer lights and sounds can reduce anxiety, pain, and distress during dental cleanings for children aged 6 to 12 who have dental fear. About 312 children will be randomly assigned to a regular dental setting o…

This study follows 250 young adult cancer survivors to see how their social relationships and physical activity change over time and how these factors affect their quality of life. Participants wear an activity tracker and complete surveys. The goal is to learn how to better supp…

This study is collecting blood, urine, tissue samples, and health information from 300 men with advanced prostate cancer. Researchers hope to build a resource that will help them learn more about the disease and improve future care. Participants will not receive any experimental …

This study looks at how people with endometrial cancer currently get medical information and how satisfied they are with it. Researchers also want to know if patients would be interested in using an artificial intelligence (AI) chatbot to help them learn about their care. The goa…

This study collects saliva samples from 500 people with newly diagnosed acute lymphoblastic leukemia to look for genetic markers linked to liver damage from the drug asparaginase. The goal is to better understand why some patients develop liver problems during treatment. No new d…

This study from the University of Southern California is testing new wearable sensors and AI software to measure mental states like mood and anxiety. Researchers will collect data from 90 healthy volunteers and epilepsy patients who already have brain electrodes implanted for med…

This study tracks T-cell changes in 250 acute myeloid leukemia patients receiving a stem cell transplant. By analyzing blood samples with advanced gene sequencing, researchers hope to understand if the immune system plays a key role in recovery and complications. The goal is to f…

This study interviews 45 adults with non-small cell lung cancer who also had a past alcohol or substance use disorder (other than tobacco). Researchers want to learn what social factors help or hinder detection and treatment of their cancer. The goal is to identify ways to improv…

This study tests whether different types of daily mindfulness breathing exercises, paired with heart rate feedback, can improve attention and memory in adults aged 50-70. Researchers will also check if these exercises change blood markers linked to Alzheimer's disease. The goal i…

This study aims to see how hearing devices affect social interaction and thinking in older adults with hearing loss. About 100 participants aged 60 and older will wear an audio sensor that tracks voice patterns during conversations, and some will also have brainwave recordings. T…

This study tests whether a training program for community specialists can help Hispanic/Latino adults learn more about colorectal cancer prevention and genetic testing. About 140 people from Los Angeles County will take part. The goal is to see if the program increases knowledge …

This study surveys 10 adult cancer patients at USC Norris Cancer Center to learn what they know and think about integrative oncology services like acupuncture, massage, and nutrition counseling. The goal is to understand patient interest and identify barriers to offering these se…

This study aims to develop a personalized brain stimulation system for depression by tracking a patient's symptoms through their brain activity. Researchers will work with 25 epilepsy patients who already have electrodes implanted for medical monitoring. The goal is to create a m…

This study tracks whether women at moderately increased risk for breast cancer get recommended screening MRIs within a year of genetic counseling. Researchers will also explore what makes it easier or harder for them to follow through. About 150 women aged 30 to 75 with certain g…

This study enrolls adults with Down syndrome ages 25-55 into a ready-to-test group. Researchers will track memory, thinking, and brain changes over time to better understand how Alzheimer's disease develops in this population. The goal is to make future clinical trials faster and…

This study tests a structured program called SENSE, where parents provide daily multisensory activities like massage, rocking, and skin-to-skin care for their preterm babies in the NICU. The goal is to see if this consistent approach improves infant brain development, language sk…

This research study collects blood, bone marrow, and tissue samples from people with cancer, blood disorders, and healthy volunteers. The goal is to study how the immune system changes during different treatments, including immunotherapy and chemotherapy. By comparing samples fro…

This study looks at how memory and thinking problems after a stroke affect a person's ability to relearn walking. Researchers will use walking tests, brain scans, and thinking assessments in 65 older adults who had a stroke at least six months ago. The goal is to understand which…

This study is testing a patient navigation program designed specifically for American Indian and Alaska Native cancer patients living in rural California. The program helps patients overcome barriers like distance, mistrust, and complex healthcare systems to get treatment faster.…

This study enrolls 50 adults with any type of cancer to test whether watching a video and reading a handout improves their knowledge and beliefs about cancer clinical trials. Participants complete a survey before and after the educational materials to measure any change. The goal…

This study is creating a large repository of blood, tissue, and health information from 10,000 adults with cancer or a high risk of developing it. Researchers will combine genetic data with medical records to better understand why some cancers respond to treatment and others do n…

This pilot study looks at two ways to treat a specific type of pelvic fracture in people aged 60 and older. One group gets early surgery to fix the bone, while the other group gets rehab without surgery. The main goal is to see if a larger study is possible, not to prove which tr…

This study surveys 40 adults with non-small cell lung cancer who are already receiving immunotherapy. Researchers want to learn how patients feel about getting treatment through an IV at the hospital versus a shot at home. The goal is to understand patient preferences and improve…

This study aims to identify different types of depression by tracking how people manage their emotions in daily life and how their nervous system responds. Researchers will test whether a simple biofeedback exercise done at home for 10 days can improve emotional regulation. The s…

This study collects small tissue samples (core biopsies) from people with known or suspected breast cancer to create a tissue repository. Researchers will use these samples to study the biology of breast cancer, including genes and proteins, to better understand how tumors grow a…

This study looks at why exercise helps some people with shoulder pain from rotator cuff tendinopathy but not others. Researchers will use brain scans to see how exercise changes the brain and find out who is most likely to get better. The goal is to make exercise treatments more …

This study collects blood samples and health information from 1,300 women who have had stage I-III breast cancer and finished active treatment. The goal is to create a biorepository that scientists can use in the future to explore links between genes, molecules, and long-term can…

This study tests whether offering a small $25 financial reward helps recruit a more diverse group of adults aged 50 and older into the Alzheimer's Prevention Trial Webstudy, an online registry that tracks memory concerns. Researchers will compare this approach to giving a non-mon…

This study aims to understand why some people with liver cancer are diagnosed at a late stage, especially those in certain neighborhoods and with low income. Researchers will survey 730 patients about challenges like transportation, food, housing, and insurance. They will also in…

This study looks at cells and biomarkers to understand why some head and neck cancers are more aggressive. Researchers will follow 50 newly diagnosed adults who have not yet received treatment. The goal is to learn more about how the cancer behaves, not to test a new treatment.

This study looks at whether removing a urinary catheter one day after colorectal surgery is as safe as the standard three days. About 176 adults having certain pelvic surgeries will be randomly assigned to early or standard removal. The goal is to see if shorter use lowers infect…

This study looks at genetic information from blood and tumor tissue of 500 Hispanic patients with colorectal cancer. The goal is to understand why some cancers respond differently to treatments. By combining genetic and clinical data, researchers hope to match treatments to each …