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Brain power may shape stroke rehab success

NCT ID NCT04829071

Knowledge-focused Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how memory and thinking problems after a stroke affect a person's ability to relearn walking. Researchers will use walking tests, brain scans, and thinking assessments in 65 older adults who had a stroke at least six months ago. The goal is to understand which learning methods work best for different people, which could lead to more personalized rehab in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could point toward more personalized rehabilitation strategies for stroke survivors with cognitive challenges.
What could go wrong
This is an early-phase observational study with only 65 participants, so results may not apply to all stroke survivors. It aims to understand mechanisms, not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 65 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Unilateral stroke * Stroke occurred more than 6 months prior * Paresis confined to one side * Independently ambulatory (including the use of assistive devices) * Able to walk for 5 minutes without stopping * Answers no to all general health questions on the PAR-Q+ * Willingness to complete study procedures Exclusion Criteria: * Brainstem or cerebellar stroke * Aphasia (expressive, receptive, or global) * Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function * Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations * Uncontrolled hypertension (\>160/110mmHg) * Concurrent physical therapy * Claustrophobia * Significant cognitive deficit or dementia (\<20 on MoCA) * Inability to give informed consent

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cva (cerebrovascular accident) Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Center for Health Professions

    RECRUITING

    Los Angeles, California, 90033, United States

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