University Of Southern California

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder together in 50 adults. Patients will receive heart failure medications and addiction counseling, plus incentives for staying meth-free. The goal is to see if this combined approach…

This study tests whether a brief digital program can help teenagers ages 12-17 who vape reduce their e-cigarette use and lower their risk of starting to smoke cigarettes. About 150 teens in California will take online surveys over 12 weeks, and some will also do a virtual intervi…

This study tests whether taking metformin-XR (a diabetes drug) daily before pregnancy can lower the risk and severity of Hyperemesis Gravidarum (HG)—extreme nausea and vomiting in pregnancy—in women aged 18-49 who had HG before and are trying to conceive. Participants either take…

This study tests K-Savvy, a 6-week online program in Korean, designed to help Korean American dementia caregivers reduce stress and depression. Researchers will enroll 120 caregivers who provide at least 10 hours of weekly care. The program adapts an existing support tool to bett…

This study compares voice therapy delivered in-person versus via telehealth for adults aged 55 and older with age-related voice problems. Thirty participants will receive four sessions of PhoRTE® voice exercises either face-to-face or through video calls. Researchers will measure…

This phase 2 trial will test whether extended-release ketamine tablets can reduce pain in 65 adults with complex regional pain syndrome (CRPS), a chronic condition causing severe, often burning pain. Participants will take either 80 mg or 160 mg of ketamine daily for several week…

This study tests whether offering free transportation, temporary housing, and meal delivery helps low-income liver cancer patients start their cancer treatment sooner. About 75 uninsured or underinsured adults with liver cancer will be randomly assigned to receive these social su…

This early study tests whether a wearable ultrasound device can safely stimulate retinal cells and help restore vision in people with age-related macular degeneration or retinitis pigmentosa. Five participants will receive short ultrasound pulses while reporting what they see. Th…

This pilot study will test whether over-the-counter (OTC) hearing aids are practical and acceptable for older adults with mild-to-moderate hearing loss who are at risk for dementia. Forty participants aged 50 and older will either use the hearing aids right away or wait three mon…

This study looks at whether a suspension walker is a practical tool for pre-walking infants with Down syndrome to use at home. Twelve infants aged 10-13 months will try using the walker for 20 minutes a day, 5 days a week over three months. Researchers want to see if families can…

This study tests whether sending a letter before a doctor's visit encourages older adults and people with serious illnesses to officially name a healthcare proxy—someone to make medical decisions if they can't. About 10,000 participants will be randomly assigned to receive differ…