Breathe better, think better: new study tests mindfulness against Alzheimer's
NCT ID NCT06410157
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study explores whether daily mindfulness practice, combined with heart rate biofeedback, can improve attention and memory in adults aged 50-70. Participants will practice breathing patterns that either increase or decrease heart rate swings. Researchers will measure changes in Alzheimer's-related blood markers and cognitive performance over 10 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- mindfulness practice with heart rate biofeedback
- What this could lead to
- If successful, this could point toward a non-drug, daily practice to help slow age-related cognitive decline and potentially reduce Alzheimer's risk.
- What could go wrong
- This is an early-stage study with 240 participants, so results may not apply to everyone. The intervention requires daily commitment, and changes in blood markers may not translate to real cognitive benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 240 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jan 2025
- Expected to finish
-
Nov 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
50 to 70 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria * Fluent in English * Black/African-American or White/European-American * Aged between 50-70 years old * Non-pregnant and non-menstruating (for at least the past year) * Have normal or corrected-to-normal vision and hearing * Have reliable access to wifi * Have an email account that you check regularly * Have a phone that receives text messages * Agree to provide blood and urine samples at two campus visits * Agree to devote up to 50 minutes daily to this study for 10 weeks as well as attend two campus visits Exclusion criteria * Have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea) * Have cognitive impairment * Have regularly played Lumosity games in the past 6 months * Have any conditions listed below that are not safe for MRI * \*Metal in any parts of your body * Claustrophobia * Have worked as a machinist, metal worker, or in any profession or hobby grinding metal? * Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body) * Cardiac pacemaker * Implanted cardiac defibrillator * Aneurysm clip or brain clip * Carotid artery vascular clamp * Neurostimulator * Insulin or infusion pump * Spinal fusion stimulator * Cochlear, otologic, ear tubes or ear implant * Prosthesis (eye/orbital, penile, etc.) * Implant held in place by a magnet * Heart valve prosthesis * Artificial limb or joint * Other implants in body or head * Electrodes (on body, head or brain) * Intravascular stents, filters * Shunt (spinal or intraventricular) * Vascular access port or catheters * IUD * Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI * Shrapnel, buckshot, or bullets * Tattooed eyeliner or eyebrows * Body piercing(s) that cannot be removed for MRI * Metal fragments (eye, head, ear, skin) * Internal pacing wires * Aortic clips * Metal or wire mesh implants * Wire sutures or surgical staples * Harrington rods (spine) * Bone/joint pin, screw, nail, wire, plate * Wig or toupee that cannot be removed for MRI * Hair implants that involve staples or metal * Hearing aid(s) that cannot be removed for MRI * Dentures or retainers that cannot be removed for MRI
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Age-related cognitive decline are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
University of Southern California
RECRUITINGLos Angeles, California, 90089, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gut bacteria may hold clues to dozens of diseases
- Can a massive data registry crack the code of Parkinson's and related brain diseases?
- Can a gentle electric current calm the mind in Alzheimer's?
- Alzheimer's vaccine aims to clear amyloid before memory fades
- Blood, eye, and brain scans team up to spot Alzheimer's earlier
- Can a home device slow Alzheimer's? pilot study tests pulsed electromagnetic therapy