Unc Lineberger Comprehensive Cancer Center

This study is testing whether a shorter, 5-session radiation treatment is safe and effective for women with early-stage breast cancer. Researchers want to see if this condensed schedule controls cancer recurrence while causing acceptable side effects and maintaining good quality …

This study is for people with a high-risk type of breast cancer who have had surgery but still have some cancer cells left. Researchers want to see if a special blood test can find signs that the cancer is coming back before it shows up on standard scans. If the blood test is pos…

This early study is testing the safety of a new cell therapy for adults with advanced lung cancer that has stopped responding to standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to better target cancer, and then infuse them back into th…

This study is testing a special radiation technique called GRID for people with soft tissue sarcoma in their arms or legs. The goal is to see if adding a single dose of GRID before standard radiation and surgery can better shrink the tumor without causing more serious wound heali…

This early-stage study is testing whether giving two drugs, XL092 and cemiplimab, before surgery is safe and helpful for people with a very aggressive type of thyroid cancer that lacks a specific genetic change (BRAF V600E). The goal is to see if this drug combination can shrink …

This early-stage study is testing the safety of a new cell therapy for pancreatic cancer that has come back after standard treatment. Doctors modify a patient's own immune cells (called CAR-T cells) to target a protein found on pancreatic cancer cells. The main goal is to find a …

This early-stage study is testing a new type of personalized cell therapy for children and young adults whose neuroblastoma or osteosarcoma has come back or hasn't responded to standard treatments. Doctors take a patient's own immune cells (T cells), modify them in a lab to bette…

This early-stage trial is testing the safety and best dose of a new two-drug combination (ulixertinib and palbociclib) for people with advanced solid tumors that have stopped responding to standard treatments. It will enroll up to 45 adults, with a specific focus on metastatic pa…

This study is testing a new cell therapy for adults with a type of T cell lymphoma that has come back or not responded to prior treatments. Doctors take a patient's own immune cells, genetically modify them in a lab to better target the cancer, and then infuse them back into the …

This early-stage study is testing the safety of combining two drugs, atezolizumab and ONC201, for women with advanced or returning endometrial cancer that has spread. The trial will enroll 58 participants, including both obese and non-obese patients, to find the best dose for fut…

This early-stage study is testing whether a gel can safely create space between the cervix and nearby organs during radiation therapy for cervical cancer. The goal is to protect healthy tissues like the rectum and bladder from radiation exposure, which may allow doctors to delive…

This early-stage study is testing the safety of a new type of treatment called CAR-T cell therapy for adults with triple negative breast cancer that has returned or stopped responding to other treatments. Doctors will collect a patient's own immune cells, modify them in a lab to …

This study is testing a lower-dose version of a three-drug combination (isatuximab, lenalidomide, and dexamethasone) for people newly diagnosed with multiple myeloma who are older or frail. The goal is to see if using lower doses can effectively control the cancer while causing f…

This early-stage trial is testing a new type of cell therapy for adults with certain blood cancers that have returned or not responded to standard treatments. Doctors modify a patient's own immune cells (T cells) in a lab to better recognize and attack cancer cells, then infuse t…

This study is testing the safety of a new type of personalized immune cell therapy for adults with glioblastoma that has returned or stopped responding to standard treatments. Doctors collect a patient's own immune cells, engineer them in a lab to target a specific protein on the…

This early-stage study is testing a new type of treatment called CAR-T cell therapy for women with ovarian cancer that has returned and is resistant to standard platinum-based chemotherapy. Doctors will collect a patient's own immune cells, modify them in a lab to better target t…

This study is testing whether genetic analysis of pancreatic tumors can predict how well patients respond to chemotherapy before surgery. Researchers will give 45 patients with non-metastatic pancreatic cancer a standard chemotherapy combination called FOLFIRINOX, then analyze tu…

This study is testing a new type of cell therapy for Hodgkin lymphoma that has come back or hasn't responded to standard treatments. Researchers are modifying a patient's own immune cells to better find and attack the cancer cells. The trial aims to find a safe dose and see how w…

This study is testing a new, experimental treatment called CAR-T cell therapy for people with head and neck cancer that has come back or stopped responding to standard treatments. The main goals are to find a safe dose and see what side effects occur. Researchers will collect a p…

This study is testing whether a 12-month, phone-based weight management program can help young adult cancer survivors (ages 18-39) who have overweight or obesity. Participants are randomly assigned to either a guided program with personalized goals, digital tools, and peer suppor…

This study is testing whether delivering healthy, frozen meals to families of children undergoing cancer treatment is a practical and helpful support. It will involve 30 families to see if the meal service is easy to use and well-liked by both parents and children. The goal is to…

This study is testing a new, detailed ultrasound imaging technique to see if it can better spot and identify cancerous tumors in the breast, liver, and kidney. It will involve 40 people, including 30 patients with known growths and 10 healthy volunteers. The main goal is to see i…

This small pilot study aims to see if a newer type of 3D X-ray scan (called CE-DBT) can give doctors the same level of confidence as a standard MRI when looking at known suspicious areas in the breast. Researchers will recruit 20 women who are already scheduled for or have recent…

This study tests two ways to help women living with HIV get screened for cervical cancer. One group will get HPV self-test kits only at clinics, while the other group can also get them from community health workers at home or in their community. The goal is to see which approach …

This study is testing if an online program that helps child care providers manage their own weight and health can lead to better eating and more physical activity for the 2-5-year-old children in their care. Researchers will work with 84 child care centers, comparing a standard h…

This study is testing whether a free, 16-week community exercise program can help people living with metastatic breast cancer. Researchers want to see if participating in the program makes it easier for patients to be active and if it improves their quality of life, physical func…

This study is testing whether a drug called memantine, combined with a supervised exercise program, can help reduce memory and thinking problems ('chemo brain') during breast cancer chemotherapy. It will involve 90 women with early-stage breast cancer who are starting chemotherap…

This study is testing if a special screening and referral program can help cancer patients get into exercise programs before they start treatment. Researchers want to see if this 'prehabilitation' helps people feel stronger, more active, and improves their overall quality of life…

This study is testing if using MRI scans to map and avoid the main saliva ducts during radiation treatment can better prevent severe, long-term dry mouth. It will compare this new approach to the standard method in 98 adults receiving radiation for throat cancer. The goal is to i…

This study is testing a coaching and navigation program called enCompass Humana, designed to support family members who are unpaid caregivers for adults with both cancer and diabetes. The goal is to see if the program is practical and acceptable, and if it can help caregivers fee…

This study is testing whether a smartphone app can deliver art therapy to help young adults who survived childhood cancer. Fifteen participants aged 18-25 will use the app for six weeks, completing weekly art prompts and surveys about their mood. The main goal is to see if this d…

This study is testing whether a dietary supplement called short-chain fatty acids (SCFAs) can reduce stomach and bowel side effects in people receiving radiation therapy for cancers in the abdomen or pelvis. About 122 participants will be randomly assigned to take either the SCFA…

This study is testing a new tool designed to help women with metastatic breast cancer and their caregivers clarify their personal values and goals. The goal is to see if using this tool improves communication with their cancer doctors and reduces the stress of making difficult tr…

This study is testing a simple weekly survey tool to help spot when cancer patients might face delays in starting their treatment. Researchers want to see if this tool works well and is easy for patients to use, and to learn more about why delays happen, particularly for differen…

This study aims to understand how the physical environment of cancer treatment spaces affects young adult patients. Researchers will survey 100 patients aged 18-39 who are receiving cancer treatment in two different infusion areas at a North Carolina hospital. The goal is to comp…

This study aims to find out which anti-vaping video ads are most effective at persuading teens and young adults not to vape. Researchers will ask 3,500 participants aged 13-20, who either vape or might try it, to watch several ads and rate them in an online survey. The goal is to…

This study is testing a new decision support tool called PRIME to see if it helps older adults with blood cancers and their doctors make initial treatment choices that better reflect what matters most to the patient. The tool asks patients about their treatment priorities and cre…

This online study aims to understand the perspectives of women who have completed treatment for early-stage breast cancer. Researchers want to know if these women are willing and able to make healthier food choices, particularly by reducing processed foods. Participants will comp…

This study is testing whether showing educational videos to patients can increase how many people with ovarian or endometrial cancer get recommended genetic testing. Researchers will enroll 30 patients to watch a video and may ask them to complete a survey. They will then check m…

This study is testing whether adding specially trained navigators to cancer care teams helps patients. The navigators help connect patients with support services and clinical trial opportunities. Researchers will measure if this leads to better quality of life and more patients j…

This study aims to understand why breast cancer outcomes differ among women, especially focusing on Black and American Indian/Alaska Native women. It will enroll 3,300 women with invasive breast cancer in North Carolina to collect biological samples, health records, and survey da…

This study is testing a blood test that looks for tiny pieces of leftover cancer DNA after surgery for early-stage breast cancer. Researchers want to see if finding this DNA can predict which patients are at higher risk of their cancer coming back, which could help doctors decide…

This study aims to understand how marketing claims on alcohol packaging affect what people think about the drinks and whether they plan to buy or consume them. About 1,500 adults who have had a drink in the past year will view images of different alcoholic beverages online and an…

This study aims to understand why some patients experience memory and thinking problems after receiving targeted radiation for brain tumors. Researchers will use special MRI scans on 15 patients over one year to see if changes in the brain's wiring are linked to these cognitive d…

This study is testing whether a detailed molecular analysis of breast cancer tumors helps doctors choose more effective treatments when the cancer has spread. Researchers will analyze tumor samples from 500 people with metastatic breast cancer and share the results with their doc…

This study is testing how easy it is to use a mobile tool that helps breast cancer patients learn about breast reconstruction options after surgery. Twenty breast cancer patients will try the tool on their phones while researchers observe and ask questions about their experience.…

This study asks cancer doctors for their feedback on a new calculator designed to estimate how long patients with advanced breast cancer might live. Researchers will interview about 15 doctors, nurses, and nurse navigators to understand what would make this tool useful and easy t…

This study aims to understand how chemotherapy for early-stage breast cancer might accelerate aging in specific organs like the heart and brain. Researchers will measure aging markers in blood samples from 60 women before and after chemotherapy treatment. The goal is to identify …

This study is testing a blood test that looks for tiny pieces of cancer DNA. It aims to see if this test can predict whether head and neck cancer comes back after a patient has surgery to remove it. Researchers will track 50 patients over time, taking blood samples before and aft…

This study is collecting and storing blood and tissue samples from patients with blood cancers like leukemia and lymphoma. The goal is to build a library of samples for researchers to study, which may help them better understand these diseases and develop new treatments in the fu…

This study is creating a registry of fluid samples from around the lungs of patients with lung cancer or infections. Researchers will collect these samples during patients' normal medical procedures to build a database for future research. The goal is to help scientists develop b…

This study is creating a large registry of 2000 adults with plasma cell disorders like multiple myeloma and amyloidosis. Participants complete health assessments about their daily function, medical conditions, and quality of life over time, and can optionally give blood samples f…

This study is creating a Spanish-language version of a proven decision aid to help Latina breast cancer survivors understand their breast reconstruction options after mastectomy. Researchers are working with 50 Spanish-speaking Latina survivors to adapt the tool to be culturally …

This study aims to create the first detailed, long-term record of lymphoma patients in Malawi. Researchers will enroll 800 people with suspected lymphoma, perform standard biopsies for accurate diagnosis, and follow their health for up to five years. The goal is to gather reliabl…

This study is testing whether visual tools help surgeons explain prostate and kidney cancer surgery options more clearly to patients. Researchers will record conversations between 20 surgeons and 200 patients before and after surgeons use the visual aids. They'll measure if discu…